Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf

Báo cáo khoa học: FH8 – a small EF-hand protein from Fasciola hepatica docx

... stability of the Ca2+-loaded FH8 is very high, and FH8 thereforebehaves like the Ca2+-loaded states of other EF-handCaBPs, namely CaM, TnC and calbindin D9K. In all of these proteins, the ... 4309–4316.24 Gopal B, Swaminathan CP, Bhattacharya A, Murthy MRN & Surolia A (1997) Thermodynamics of metal ion binding and denaturation of a calciumbinding protein from Entamoeba histolytica.Biochemistry ... and D,60–68 ⁄ 58–68. Ca2+-binding sites I and II have the appropriate amino acids and geometry to coordinate the metal ions, and are located in loop regions (15–26) and (51–62) that are ﬂanked...

Báo cáo khoa học: Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus pdf

... and mammalian Na+channels. Accordingly, they are dividedinto classical a- toxins that are highly active in mammalianbrain, a- toxins that are very active in insects and a- liketoxins that are active ... were obtained from data bank and the abbreviations stand for: AaH, Androctonus australisHector; Amm, Androctonus mauretanicus mauretanicus;Bj,Buthotus judaicus;Bot,Buthus occitanus tunetanus;Cn,Centruroides ... isolated from the venom of the Mexican scorpionAnuroctonus phaiodactylusNorma A. Valdez-Cruz1, Cesar V. F. Batista1, Fernando Z. Zamudio1, Frank Bosmans2, Jan Tytgat2 and Lourival D....

Báo cáo khoa học: "Towards a Semantic Classiﬁcation of Spanish Verbs Based on Subcategorisation Information" doc

... reveals thatthey are intuitively plausible, and that the evalua-tion is penalised by the fact that the target classesare of very different sizes. On the other hand, ourdata takes into account ... or grammatical function of the constituents, we have to take into accountthat the extraction is an approximation. There arevarious phenomena that can lead us to an erroneousextraction of the ... patterns the heads of the prepositionalphrases, the corpora contain a large number of pat-tern types (838 in the small corpora, and 2099 in the large corpora). We investigate grouping seman-tically...

Báo cáo khoa học: An a-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum Cloning and biochemical characterization of the enzyme potx

... MDHcatalysed the reduction of OAA with an e fﬁciency six toeight times greater than that o f oxidation of malate asdetermined by evaluation of Vmax and kcatvalues formalate/NAD and OAA/NADH ... characterization of the enzymeAbhai K. Tripathi1, Prashant V. Desai2, Anupam Pradhan1, Shabana I. Khan1, Mitchell A. Avery1,2,Larry A. Walker1,3 and Babu L. Tekwani11National ... Embden–Meyerhof–Parnas pathway o f glycolysis and the tricarboxylic acid(TCA) cycle in malarial parasites [4]. However, the role of oxidative metabolism in the malaria parasite through the TCA cycle...

Báo cáo khoa học: "Bootstrapping a Uniﬁed Model of Lexical and Phonetic Acquisition" potx

... baw:1, ahbaht:1, erbawd:1,bawd:1, ahbaad:1, ahpaat:1, bah:1, baht:1,ah:1, ahbahd:1, ehbaat:1, ahbaed:1, ihbaht:1,baot:1“wanna”waanah:94, waanih:37, wahnah:16, waan:13,wahneh:8, wahnih:5, wahney:3, ... waanlih:3,wehnih:2, waaneh:2, waonih:2, waaah:1,wuhnih:1, wahn:1, waantah:1, waanaa:1,wowiy:1, waaih:1, wah:1, waaniy:1Table 2: Empirical distribution of pronunciations of “about” and “wanna” ... early languageacquisition skills: Towards a general statistical learningmechanism. In Proceedings of the Student ResearchWorkshop at EACL.Armen Allahverdyan and Aram Galstyan. 2011. Compar-ative...

Báo cáo khoa học: NtKTI1, a Kunitz trypsin inhibitor with antifungal activity from Nicotiana tabacum, plays an important role in tobacco’s defense response pot

... albumin of Theobro-ma cacao. Identiﬁcation of the protein as a member of the Kunitz protease inhibitor family. Planta 183,528–535.27 Yamagata H, Kunimatsu K, Kamasaka H, KuramotoT & Iwasaki ... activated. After the recognition of tobacco and phytopathogen, the transcript of NtKTI1is repressed and the signal transduction pathway of plant defense, such as the SA signaling pathway, isactivated, ... obviouslyantifungal activity against R. solani, Rh. nigricans and P. parasitica var. nicotianae, but does not inhibitF. oxysporum, Physalospora piricola, Alternaria alter-nata, Magnaporthe grisea,...

Báo cáo khoa học: "Cloning a new allele form of bovine TNF-α Jongsam Ahn" pdf

... 5’-GAA GCT AGC ATG AGC ACC AAA AGCATG ATC CGG-3’ and R primer 5’-GAA CTC GAG TCACAG GGC GAT GAT CCC AAA GTA-5’. PCR mixture(100µl) contained 10µl of 10× PCR buffer, 3µl of 50mM MgCl2, ... constructed according to manufacturer’sprotocol using Gubler and Hoffman’s method. Doublestrand cDNA was fractionated on a 1% agarose gel. cDNAfractions between 0.75 kb-2 kb and larger than 2 kb ... vitro, and the susceptibility to and clinical severity of diseases in human and mouse.Comparative sequence analysis revealed the presence of allele forms of TNF-α in promoter region and/ or encodingregion...

Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf

... earliestGossypol and radiation activate the SAPK/JNK pathwayFigure 4Gossypol and radiation activate the SAPK/JNK pathway. A: AT-101 is a stronger activator of SAPK/JNK than racemic (±)-gossypol. ... cell survivalafter radiation.Gossypol and radiation activate the SAPK/JNK pathway Because SAPK/JNK- mediated signaling plays an importantrole in radiation-, chemotherapy- and environmentalstress-induced ... CentralPage 1 of 10(page number not for citation purposes)Radiation OncologyOpen AccessResearch AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK...

Báo cáo y học: "Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells" pps

... Densitometric analysis of these results. Inten-sity of each band was normalized relative to that of β-actin in the same lane, and the mean ± standard deviation of the five cell lines are shown. ... Takatsuna H, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C,Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K: Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novelNF-kappaB inhibitor, ... After 21 days (day 0) the sameamount of the antigen emulsified in the same adjuvant wasintradermally injected at the base of the tail as a booster immu-nization. By day 5, 20 out of the 25 mice...

Báo cáo y học: "LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cell" pps

... CentralPage 1 of 9(page number not for citation purposes)AIDS Research and TherapyOpen AccessResearchLMP-420, a small- molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium ... inexpensive, small- molecule, orally-active drugs may represent a useful strategy for enhancing the activity of currently-available antiviral and anti-M. Tb agents, particularlyin those areas where ... Sha BE, Valdez H, Gelman RS, Landay AL, Agosti J, Mitsuya R, PollardRB, Mildvan D, Namkung A, Ogata-Arakaki DM, Fox L, Estep S, Erice A, Kilgo P, Walker RE, Bancroft L, Lederman MM: Effect of...

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