Báo cáo khoa học: " Pharmacokinetics and biodistribution of Erufosine in nude mice implications for combination with radiotherapy" pot

... a possible combination of Erufosine and radiotherapy in vivo we determined the pharmacokinetics and bioavailability as well as the tolerability of Erufosine in nude mice. Methods: NMRI (nu/nu) nude mice ... Oncology Open Access Research Pharmacokinetics and biodistribution of Erufosine in nude mice - implications for combination with radioth...

Ngày tải lên: 09/08/2014, 10:20

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Ngày tải lên: 07/08/2014, 18:21

... Disulfiram inhibits activating tran- scription factor ⁄ cyclic AMP-responsive element binding protein and human melanoma growth in a metal-depen- dent manner in vitro, in mice and in a patient with metastatic ... m )1 Æmin )1 ) in vivo and in vitro. This inhibi- tion also occurs through the formation of an adduct with the NAT1 active site cysteine, which cannot be red...

Ngày tải lên: 07/03/2014, 02:20

... N-terminal EF hand pair of CaM contains important binding and activating elements for iNOS, whereas the N-terminal EF hand pair in conjunction with the cen- tral linker region is required for cNOS ... domains bind NADPH, FAD, and FMN, and the oxygenase domain con- tains binding sites for heme, tetrahydrobiopterin (H 4 B), and the substrates l-arginine and molecular oxyge...

Ngày tải lên: 16/03/2014, 13:20

... binding site could be identified in the C-terminal domain of geodin, defined by Asn93 and Asn145. Spherulin 3A, a single-domain mould protein with crystallin fold, has two distinct Ca 2+ binding ... kJÆmol )1 for human-c S and spherulin 3a, and of 41 and 45 kJÆmol )1 for geodin and protein S, respectively. The value of 45 kJÆmol )1 for protein S is the value cal- culat...

Ngày tải lên: 30/03/2014, 15:20

... obvious role of antidepressants in the background of declining suicide rates, the US Food and Drug Administration recently issued a warning con- cerning the use of antidepressants in children and adoles- cents, ... especially GPs in recognizing and treating depression and anxiety. A shift of focus of attention is required in primary care to detect potentially suicida...

Ngày tải lên: 08/08/2014, 23:20

... I) for 30 s and 72 ◦ C for 30 s, and to a final extension step of 5 min. 2.3. Sequencing The sequencing reactions were performed on the PCR products directly using a Dye Terminator kit (Perkin ... resulting in different systems of cytogenetic nomenclature. The first international nomenclature of the bovine karyotypes was estab- lished in 1976 during the Reading conference usin...

Ngày tải lên: 09/08/2014, 18:21

... accelerating effect of heat shock may interfere with and compensate potential slowing down due to consanguinity, if any. In rainbow trout however, gynogenesis by retention of ... between 10 and 90 % of hatched fry. Mean time of hatching (TH) was defined as being the time in (°C.d) when 50 % of the fry hatched, and duration of ha...

Ngày tải lên: 09/08/2014, 22:22

... extension of the low dose areas, the degree of uniformity of doses within the PTVs and the potential presence of hot spots. Table 3 presents for all OARs, PTVs and HTis, for all patients and for the ... defined volumes of interest. MA performed planning on Masterplan. ML performed planning on Pinnacle. AF and GN performed planning on Eclipse. JM and MA performed plan...

Ngày tải lên: 09/08/2014, 10:21

... match with respect to domain and time is also impor- tant, and presentspreliminary experiments with training data labeled with emoticons, which has the potential of being indepen- dent of domain, ... more training data will im- prove the performance of the Emoticon-trained clas- sifiers by increasing the coverage. Potential sources for this include online bulletin boards, cha...

Ngày tải lên: 17/03/2014, 06:20