Báo cáo khoa học: "Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression" pot

... report Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression Pedro C Lara* 1,2 , Marta Lloret 1,2 , Bernardino Clavo 1,2 , Rosa M Apolinario 2 , Luis ... phenome- non of hypoxia- induced genetic instability within the tumor [4]. Hypoxia is measured in clinical tumors by sev- eral techniques, including the Eppendorf polarogr...

Ngày tải lên: 09/08/2014, 10:20

... where baseline indicates the supervised classifier 3 f trained on the 10% data; both co-training and single classifier and co-training and combined classifier refer to co-training using our ... 422 Supervised Machine Learning Techniques Coupled with Feature Selection. In Processing of Advances in Web Mining and Web Usage Analysis. Džeroski S. and B. Ženko. 2004. Is Combining Cla...

Ngày tải lên: 07/03/2014, 22:20

... shown to bind to and inhibit the ser- ine–threonine protein phosphatase calcineurin [5]. The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is highly ... data from other studies showing decreased calcineurin activ- ity in AD, and other data showing that calcineurin inhibition results in tau phosphorylation on serine and threonine resid...

Ngày tải lên: 16/03/2014, 11:20

... q is displayed in Fig. 4, showing that two regions can be defined in the space of kinetic parameters (q, K S1 ), one resulting in bistable behavior and the other resulting in a single stable steady ... the following constraints are satisfied (this way of calculating the bifurcation point is equivalent to linearizing the system defined by Eqn (2) around the steady state and calculating th...

Ngày tải lên: 16/03/2014, 13:20

... progression, through several mechanisms including increased cyclin D transcription and translation, inhibitory phosphory- lation and reduced transcription of cyclin-dependent kinase (CDK) inhibitors. In ... found that Pfkfb3 gene silencing induces cell cycle delay, corrobo- rating its role in sustaining high glycolytic flux in pro- liferative cells and its involvement in cell cycle...

Ngày tải lên: 30/03/2014, 01:20

... Detection of Lawsonia intracellularis in diagnostic specimens by one-step PCR 35 including S. hyodysenteriae, Campylobacter spp., and Salmonella spp. which cause intestinal diseases in swine, were used ... Multiplex polymerase chain reaction for simultaneous detection of Lawsonia intracellularis, Serpulina hyodysenteriae, and salmonellae in porcine intestinal specimens. J. Vet. Diag. In...

Ngày tải lên: 07/08/2014, 14:22

... therapists use research findings in clinical decision making rarely or not at all, and only 13.3% of therapists integrate research in clinical decision making 6+ times in a typical month. The ... class assignments and clinical internships for students to experience success in searching and appraising the research literature and incorporating it in clinical decision making (i...

Ngày tải lên: 10/08/2014, 10:23

... Achieving the Potential of System Integration Through Innovation, Leadership, Measurement, and Incentives. In Book Geisinger Health System: Achieving the Potential of System Integration Through Innovation, ... preventable by applying accepted definitions of preventable conditions [2,25,43], specifying the phenom- ena driving readmission [ 44,45], detailing a clinical link [26], or out...

Ngày tải lên: 10/08/2014, 10:23

... eukary- otic initiation factor 4E-binding protein (4E-BP1) with the mRNA cap-binding factor eIF4E in cells Keywords caspases; interferon-a; polypeptide chain initiation; protein synthesis; TRAIL Correspondence M. ... has not previously been investi- gated. We therefore examined the effect of increasing concentrations of TRAIL on the incorporation of [ 35 S]methionine into total protein in...

Ngày tải lên: 19/02/2014, 06:20

... DNA and DNA-binding proteins, to induce a change in nucleosome positioning. In our model plasmids used, the binding of a2 ⁄ Mcm1 repressor to its legitimate binding site has a critical role in the ... are supplied. Incorporation of 5-bromouracil into the plasmid did not weaken the binding of the a2 ⁄ Mcm1 repressor complex to its legitimate binding site, as revealed by an in vivo UV p...

Ngày tải lên: 15/03/2014, 23:20