Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps

... Access Research Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking Pirus Ghadjar † , Jacqueline Vock † , Daniel ... patients treated by dose escalated intensity- modulated radiation therapy (IMRT) and organ tracking. Methods: From 06/2004 to 12/2005 39 men...

Ngày tải lên: 09/08/2014, 09:22

... for HGF-induced scattering [15-17]. In colon cancer cells, MAPK signaling could be hyperactive by transfection of MACC1, and HGF-induced cell scattering mediated by MACC1 could be abrogated by MEK ... downstream signaling cascades, such as MAPK and PI3K/Akt pathways [14]. MACC1 protein contains several domains which can participate in MAPK signaling, and MACC1 can be up-regu...

Ngày tải lên: 10/08/2014, 10:21

... suffered severe late GI toxicity, and 26 patients (WP-11.21% and PO-16.05%) severe late GU toxicity. In the majority of acute toxicity suffering patients, the diminution of late GI/GU toxicity to ... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1]. Thus late rectal and urinary damage...

Ngày tải lên: 09/08/2014, 09:20

... in predicting radiation induced toxicity. Seventy nine consecutive patients suffering from head and neck cancer, diagnosed and treated in our institution, were included in the study. Toxicity ... the intraindividual and interindivi- dual variations were determined in the four healthy donors and in the 79 patients. Intraindividual variation for healthy donors was a...

Ngày tải lên: 09/08/2014, 10:20

... development, and intracellular signaling [10–12]. Thrombin is involved in many biological processes. In addition to its function in blood coagulation and wound healing, thrombin has diverse functions in ... protein family members all contain fibrinogen-related domains (FRED), known to represent key regions for protein– protein interaction. As a procoagulant, fgl2 is involved in c...

Ngày tải lên: 20/02/2014, 11:20

... of the C-terminal glycine in ThiS and MoaD, involved in thiamine biosynthesis and molyb- dopterin biosynthesis, respectively, and for the sulfura- tion of uridine in tRNA to thiouridine can be envisaged ... phenylalanine instead of a tyrosine directly before the thioglycine (Methanoculleus thermophilus and Methanosarcina barkeri) or directly after the thioglycine (Methanosarcina...

Ngày tải lên: 16/03/2014, 05:20

... that VD3 could induce differentia- tion and cell cycle arrest in a number of malignant melanoma cells, including those in myeloid leukemia, and breast, prostate, colon, skin and brain cancer [4– 8]. Phosphatase ... 989 Vitamin D promoted the apoptosis induced by 5-Aza We then investigated the effect of PTEN on the apop- tosis induced by DNA methylation and vitamin D in ga...

Ngày tải lên: 22/03/2014, 21:20

... Ninety four consecutive patients suffering from cervical carcinoma, diagnosed and treated in our institution, and four healthy controls were included in the study. Toxicity was evaluated using ... annexin V binding buffer. Cells were incubated with 4 μl of annexin V-FITC and 10 μl of propidium iodide (PI) for 15 minutes at room temperature in the dark. Finally, 400 μl of 1×...

Ngày tải lên: 09/08/2014, 10:20

... domains connected by an a-helix andeachdomainhastwoCa 2+ -binding sites (EF-hand motifs) [4]. The Ca 2+ -binding properties of isolated TnC are well known. Sites III and IV in the C-domain (carboxy terminal) ... naturally occurring fluorescent amino acids, tyrosine or tryptophan, or the use of proteins labeled with extrinsic attached probes to analyze ligand binding, protein–protein inte...

Ngày tải lên: 20/02/2014, 11:20

... G-protein- coupled receptor; and this binding activates the downstream signaling pathways including the Gq heterotrimeric G protein, and then further increases the intracellular calcium level and ... with an MEK inhibi- tor, PD98059; a PLC inhibitor, U73122; a PKC inhibitor, bisindolylmaleimide I; and a general COX inhibitor, indomethacin, or a selective COX-2 inhibi- tor, NS-398, in...

Ngày tải lên: 28/03/2014, 22:20