Báo cáo khoa học: "The prognostic value of the nodal ratio in N1 breast cancer" pps

... (ECE), presence of lymphovascular invasion (LVI), and resection margin status. A close margin was defined as the presence of invasive carcinoma within 2 mm of the surgical margin of resection. ... Y: Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol 2006, 24:2910-2916. 5. Truong PT, Berthelet E, Lee J, Kader HA, Olivotto IA: The progn...

Ngày tải lên: 09/08/2014, 09:21

... from ZOL, the risk-reducing measures should be considered. These measures included reducing the dose, slowing the infusion rate and prolonging the interval between infusions. When the patients ... interpretation of data, the revision of the article as well as final approval of the version to be submitted. WBZ and XAL participated in the design of the study, perfo...

Ngày tải lên: 10/08/2014, 10:21

... proteins bind their cognate DNA-bind- ing site, they generally bind to other DNA-binding cofactors [10–12]. Meis2 is a member of the TALE superfamily of HD proteins, which are characterized by the ... for the inhibi- tory effect of the Hth domain, we created a series of GDB fusion proteins (Fig. 4F). Deletion of either the N-terminal 65 or the N-terminal 97 amino acids d...

Ngày tải lên: 16/02/2014, 15:20

... depending on the cut-off value used to discriminate between the two severity classes in the test data. The broken line repre- sents prediction on test data and the full line on training data. The straight ... procedures. In the local minimiza- tion, the sum of the energy terms was minimized locally in the direction in which the total energy gradient was the...

Ngày tải lên: 18/02/2014, 11:20

... out of 20 uridine residues in 23S rRNA and one out of eight uri- dine residues in 16S rRNA to pseudouridine [9]. We have analyzed the substrate specificity of the pseudouridine synthase RluD in ... 50 lL of water (10 min at room temperature). Determination of pseudouridines Pseudouridines were determined according to the method of Ofengand [34]. Fifteen micrograms rRNA...

Ngày tải lên: 18/02/2014, 16:20

... environments of BPA in the ligand-binding pocket of the ERRc. The proximity of each amino acid residue (within a distance of 5 A ˚ ) to BPA is shown in the boxes depicting the a -heli- ces. The portrait ... activity of the latter and to reverse the deactivating inverse agonist activity of 4-hydroxytamoxifen. However, the intrinsic binding mode of bisphenol...

Ngày tải lên: 18/02/2014, 16:20

... conserved in the sequence of saccharopepsin, the validity of this inter- pretation was examined by determination of inhibition constants for the interaction of the N-terminally exten- ded inhibitors ... to the right and the addition of further residues at the N-terminus or beyond residue 34 of the inhibitory segment is superfluous. However, in the case of Pp...

Ngày tải lên: 19/02/2014, 00:20

... understanding of the folding mechanism(s) and the factors affecting protein stabilization, in this article we extend our knowledge on anion–protein interactions by determining the effect on the protein ... of structured forms of proteins and are often employed in studies aimed at clarifying aspects of the folding process of proteins [34], including cytochrome c [18]. C...

Ngày tải lên: 19/02/2014, 05:20

... [20]. Why is the less active SP isoform of type III AFP dominant in the fish serum? In winter, the level of expression of AFPs is maximized to  20–30 mgÆmL )1 in the serum [33]. The SP isoform is ... Ala20 in the presently examined SP isoforms, nfeAFP2 and nfeAFP6. The replacement of these residues presumably alters the ice-binding character of the AFP isof...

Ngày tải lên: 19/02/2014, 16:20

... function of the changing input variable with the other input variables set at their physiological values. The dotted lines in the graphs indicate the value of the changing input variable in the physiological ... In the following the model is used to investigate the sensitivity of the two-enzyme system to the different input variables and to explain the...

Ngày tải lên: 20/02/2014, 02:21