... LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, the FYRC domain and the SET domain.Moreover, ... limitsDNA damage and maintains self-renewal of leukaemiastem cells. Nature 457, 51–56.49 Seoane J, Le HV, Shen L, Anderson SA & Massague´J(2004) Integration of Smad and forkhead pathways in the ... 47–58.Supporting information The following supplementary material is available:Table S1. All protein-protein interaction data wereobtained from the biogrid Database (www.thebiogrid.org) and listed according...