... REPOR T Open Access Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study Oliver Riesterer 1† , ... syngenic mammary carcinoma allografts (A) and orthotopic spontaneous mammary carcinomas (B) in response to IR (4 × 3 Gy) and PTK787 (...
Ngày tải lên: 09/08/2014, 09:20
... from mitochondria, and apoptotic cell death. Radiation also induced transcrip- tional upregulation of Fas, caspase-8 activation, Bax and Bak activation, and phosphorylation and downregulation of Bcl-2. Inhibition ... association of FADD and caspase-8 in HeLa cells after radiation treatment. As shown in Fig. 1C, interaction between FADD and caspase-8 was increased...
Ngày tải lên: 07/03/2014, 05:20
Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt
... Belakhov V, Lee LV, Liang F-S, Wong C-H & Baasov T (2005) Dual effect of synthetic amino- glycosides: Antibacterial activity against Bacillus anthra- cis and inhibition of anthrax Lethal Factor. ... modes of substrate bind- ing, which are manifested in substrate inhibition. The synthetic substrate, a nonapeptide with an N-terminal ortho-aminobenzoyl and a C-terminal di...
Ngày tải lên: 19/02/2014, 06:20
Báo cáo khoa học: Unusual venom phospholipases A2 of two primitive tree vipers Trimeresurus puniceus and Trimeresurus borneensis ppt
... Tpu-G6D49 was also capable of inducing fast and sustained local edema. The inhibition of ADP-induced platelet aggre- gation by acidic E6-PLA 2 s or the weak basic G6-PLA 2 from both venoms was also ... puniceus and Trimeresurus borneensis Ying-Ming Wang, Hao-Fan Peng and Inn-Ho Tsai Institute of Biological Chemistry, Academia Sinica and Institute of Biochemical Sciences, Nat...
Ngày tải lên: 07/03/2014, 17:20
Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... subunits of clathrin-associated adaptor protein (AP) complex AP 2A1 and AP 2A2 , clathrin heavy chain 1 (CLH1), and clathrin heavy chain 2 (CLH2), clathrin light chain A (CLTA), and clathrin light chain ... domain and increases the transcriptional activity of AR on known AR-inducible promoter. Treatment with androgen increases the nuclear fraction of AR as well as that of HI...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: "Estimating the foliage area of Maritime pine (Pinus pinaster Aït.) branches and crowns with application to modelling the foliage area distribution in the crown" pptx
... trees and stands Table V. Summary of the stands characteristics and LAI (leaf area index) per stand and needle age as calculated using the crown level leaf area model with DBH and age as independent ... stand foliage area by the stand area. For the 21 and 26 year-old stands, stand foliage area was calculated as the sum of the leaf area of each tree; the latter was estimated by...
Ngày tải lên: 08/08/2014, 14:21
Báo cáo khoa học: "Intraductal papillary mucinous neoplasm of the pancreas (IPMN): clinico-pathological correlations and surgical indications" pptx
... Ishikawa O, Ohigashi H, Sasaki Y, Yamada T, Nakaizumi A, Uehara H, Takenaka A, Kasugai T, Imaoka S: Role of intraoperative cytology combined with histology in detecting continuous and skip type intraductal ... 27:10. 8. Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS: Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas...
Ngày tải lên: 09/08/2014, 03:21
Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
... The appearance of an intermediate molecular form can also be seen as a 74 kDa protein. Both C-terminal cleavages were proposed to be accom- plished in an intermolecular fashion in vivo [10] and ... able to activate mPC1 ⁄ 3 at near neutral pH. A fixed amount of mPC1 ⁄ 3 was incubated in the presence of increasing amounts of RP-HPLC purified CT-peptide at pH 7.8 and the amo...
Ngày tải lên: 30/03/2014, 08:20
Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... swapping to occur. It is of interest that a N-terminally truncated pri- on protein, lacking the copper binding domain is cap- able of domain swapping and forms a dimer as revealed by crystal ... for cloning and isolating the recombinant proteins. We also are grateful to Sabina Rabzelj and Sas ˇ a Jenko Kokalj for performing certain SEC experiments and for activity measuremen...
Ngày tải lên: 19/02/2014, 06:20
Báo cáo khoa học: Anti-HIV-1 activity of 3-deaza-adenosine analogs Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners pot
... West Palm Beach, Florida, USA; 6 Bioinformatics Laboratory, International Institute of Molecular and Cell Biology, Warsaw, Poland Eight adenosine analogs, 3-deaza-adenosine (DZA), 3- deaza-(±)aristeromycin ... indicator: 2-propanol/concentrated ammonia/water, 7 : 1 : 2, v/v/v). The radioactivity was quantitated by cutting the plastic backed TLC plates and placing them in scintillation...
Ngày tải lên: 08/03/2014, 08:20