Báo cáo khoa học: "Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study " pdf

Báo cáo khoa học: "Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study." pdf

... REPOR T Open AccessIonizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study Oliver Riesterer1†, ... syngenic mammary carcinoma allografts (A) and orthotopic spontaneous mammary carcinomas (B) in response to IR (4 × 3 Gy) and PTK787 (4 × 100 mg/kg) alone and in combination. For the allograft tumor ... tumor model Spontaneous tumor modelFigure 1 Similar treatment response in spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model. Tumor growth delay of syngenic mammary...

Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for ampliﬁcation of mitochondrial apoptotic cell death in human cervical cancer cells pptx

... frommitochondria, and apoptotic cell death. Radiation also induced transcrip-tional upregulation of Fas, caspase-8 activation, Bax and Bak activation, and phosphorylation and downregulation of Bcl-2. Inhibition ... association of FADD and caspase-8 in HeLa cells after radiation treatment. As shown in Fig. 1C, interaction betweenFADD and caspase-8 was increased in cells treatedM J. Kim et al. Role of JNK in radiation- induced ... analysis was performed using anti-FADD, anti-caspase-8, anti-caspase-3, anti-poly(ADP-ribose) polymerase (PARP) and anti-b-actin serum. b-actin was used as a loading control.Role of JNK in radiation- induced...

Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt

... Belakhov V, Lee LV, Liang F-S, WongC-H & Baasov T (2005) Dual effect of synthetic amino-glycosides: Antibacterial activity against Bacillus anthra-cis and inhibition of anthrax Lethal Factor. ... modes of substrate bind-ing, which are manifested in substrate inhibition. The synthetic substrate, a nonapeptide with anN-terminal ortho-aminobenzoyl and a C-terminal dinitro-phenyl, contains ... acetylcholine esterase by N-methylacri-dinium (electrical charge ZL¼ +1), and found thatat the point of initial attachment, the enzyme and inhibitor molecules are separated by a d of %14 A ˚.From...

Báo cáo khoa học: Unusual venom phospholipases A2 of two primitive tree vipers Trimeresurus puniceus and Trimeresurus borneensis ppt

... Tpu-G6D49 wasalso capable of inducing fast and sustained localedema. The inhibition of ADP-induced platelet aggre-gation by acidic E6-PLA2s or the weak basic G6-PLA2from both venoms was also ... puniceus and Trimeresurus borneensisYing-Ming Wang, Hao-Fan Peng and Inn-Ho TsaiInstitute of Biological Chemistry, Academia Sinica and Institute of Biochemical Sciences, National Taiwan University, ... FaureG, Lambeau G, Valentin E, Singer A, Ghomashchi F,Beguin S, et al. (2000) Basic residues of human groupIIA phospholipase A2 are important for binding to fac-tor Xa and prothrombinase inhibition. ...

Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

... subunits of clathrin-associated adaptor protein (AP) complexAP 2A1 and AP 2A2 , clathrin heavy chain 1 (CLH1), and clathrin heavy chain 2 (CLH2), clathrin lightchain A (CLTA), and clathrin light chain ... domain and increases the transcriptionalactivity of AR on known AR-inducible promoter.Treatment with androgen increases the nuclear fraction of AR as well as that of HIP-1, indicating that ... neuro-nal intranuclear inclusions. Aggregates ⁄ neuronal intra-nuclear inclusions are observed in cell models, brains of transgenic animals, and post-mortem brains of HDpatients [2]. Aggregate...

Báo cáo khoa học: "Estimating the foliage area of Maritime pine (Pinus pinaster Aït.) branches and crowns with application to modelling the foliage area distribution in the crown" pptx

... trees and standsTable V. Summary of the stands characteristics and LAI (leaf area index) per stand and needle age as calculated using the crownlevel leaf area model with DBH and age as independent ... standfoliage area by the stand area. For the 21 and 26 year-oldstands, stand foliage area was calculated as the sum of the leaf area of each tree; the latter was estimated byFigure 2. Estimated branch ... leaf area of eachsampled tree by the number of trees in its class, and summed the 30 values to calculate the stand foliage area.Table V presents the LAI values for each cohort and stand, and...

Báo cáo khoa học: "Intraductal papillary mucinous neoplasm of the pancreas (IPMN): clinico-pathological correlations and surgical indications" pptx

... Ishikawa O, Ohigashi H, Sasaki Y, Yamada T, Nakaizumi A, Uehara H, Takenaka A, Kasugai T, Imaoka S: Role of intraoperative cytologycombined with histology in detecting continuous and skip typeintraductal ... 27:10.8. Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS: Intraductalpapillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002, ... Shimizu M,Yamaguchi K, Yamao K, Matsuno S, International Association of Pancreatology: International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cysticneoplasms...

Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf

... The appearance of an intermediatemolecular form can also be seen as a 74 kDa protein.Both C-terminal cleavages were proposed to be accom-plished in an intermolecular fashion in vivo [10] and ... able to activate mPC1 ⁄ 3 at near neutralpH. A ﬁxed amount of mPC1 ⁄ 3 was incubated in the presence of increasing amounts of RP-HPLC puriﬁed CT-peptide at pH 7.8 and the amount of AMC released ... Thedata generated were analyzed with the analystTM-qs v 1.1software (Applied Biosystems ⁄ MDS-Sciex).Enzymatic assays and kinetic analysisAll enzymatic assays of recombinant mPC1 ⁄ 3 were carriedout...

Tài liệu Báo cáo khoa học: High afﬁnity copper binding by steﬁn B (cystatin B) and its role in the inhibition of amyloid ﬁbrillation docx

... swapping tooccur. It is of interest that a N-terminally truncated pri-on protein, lacking the copper binding domain is cap-able of domain swapping and forms a dimer as revealedby crystal ... forcloning and isolating the recombinant proteins. Wealso are grateful to Sabina Rabzelj and Sasˇ a JenkoKokalj for performing certain SEC experiments and for activity measurements. We are grateful ... 2 of ste-ﬁn B and the P79S mutant of the variant atboth pH 7 and pH 5. Each panel is a plot of heat change on ligand addition (kcalÆmole)1)against the ligand ⁄ steﬁn molar ratio for oneof...

Báo cáo khoa học: Anti-HIV-1 activity of 3-deaza-adenosine analogs Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners pot

... West Palm Beach, Florida, USA;6BioinformaticsLaboratory, International Institute of Molecular and Cell Biology, Warsaw, PolandEight adenosine analogs, 3-deaza-adenosine (DZA), 3-deaza-(±)aristeromycin ... indicator:2-propanol/concentrated ammonia/water, 7 : 1 : 2, v/v/v).The radioactivity was quantitated by cutting the plasticbacked TLC plates and placing them in scintillation vials, and counting in a Packard 2000 CA ... 3-deaza-nucleoside analogs of adenosine (Fig. 1),3-deaza-adenosine (DZA), 3-deaza-(±)aristeromycin(DZAri), and 3-deaza-neplanocin A (DZNep) are potentinhibitors of S-adenosylhomocysteine hydrolase...

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