Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
... AccessCombined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high- dose radiotherapyLuis Alberto ... Henríquez-Hernández et al.: Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high- dose radiotherapy. ... possibility to develop new pre-dictor assays taking into account the initial DNA damage and radiation-induced apoptosis levels, and introduces new data w hich may help to understand and define the...
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Tài liệu Báo cáo khoa học: A novel nuclear DNA helicase with high specific activity from Pisum sativum catalytically translocates in the 3¢fi5¢ direction docx
... for10 min at 4 °C in a Sorvall RC 5B centrifuge. The pellet wasslowly resuspended in NE-1 buffer containing 2.5%Triton · 100, and incubated at 4 °C with slow shaking (to lyse the chloroplast) and ... the amount of enzyme that unwinds 30% ofthe DNA helicase substrate at 37 °Cin30min(1 %in one min). For examining the effect of DNA- interactingcompounds on DNA unwinding activity of PDH120, thecompounds ... (Mg2+>Mn2+)isrequired.The DNA intercalating agents actinomycin C1, ethidium bro-mide, daunorubicin and nogalamycin inhibit the DNA unwinding activity of PDH120 with Kivalues of 5.6, 5.2, 4.0 and 0.71 lMs,...
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Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
... bythe N-domain and C-domain varies according to theACE species. For rat and human enzymes, estimationof IC50values for the binding of the inhibitor to theN-domain and C-domain can be deduced ... free of inhibitor. Foreach species and each inhibitor, ACE was incubated with the inhibitor for 45 min before substrate addition. The kin-etic parameters were determined using the direct linear ... and human somatic ACE. Kinetic parameters kcat and Kmwere obtained by inhibiting the activity of the C-domain of ACE with RXPA380 (active N-domain) or by inhibiting the N-domain activitywith...
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Báo cáo khoa học: Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus docx
... Over-expression of dominant-negativecaveolin-1 and short hairpin RNA-mediated knock-down of caveolin-1 significantly inhibited infectionwithout affecting the initial internalization [63]. In addition, ... receptor binding and for theinduction of neutralizing antibodies. Indeed, bindingsites of some neutralizing antibodies have been mapped to the C-terminal arm [15].Under forced expression, up to ... located within the cleft con-tribute to cell binding. It is hoped that the determina-tion of the structure of HPV particles in complex with its attachment receptor heparan sulfate in combinationwith...
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Báo cáo khoa học: Stability of the major allergen Brazil nut 2S albumin (Ber e 1) to physiologically relevant in vitro gastrointestinal digestion doc
... IgE-binding epi-topes characterized to date in 2S albumin allergens arelocated in the large chain. Therefore, a common IgEepitope has been described in the large chain of 2Salbumins from yellow ... signal and propeptide regions, and therefore would not be present in the mature protein,but the remainder corresponded to the large chain, with two also containing cysteine residues 12, 13, 23 and ... degradation in theGI tract (such as resistance to low pH, bile salts and proteolysis), thus allowing enough allergen to survive in a sufficiently intact form to be taken up by the gut and sensitize...
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Báo cáo khoa học: " Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex" doc
... nigrostriatal pathway and intrinsic circuits provide the striatum with dopamine, acetyl choline, GABA, NO and adenosine. Together, these neurotransmitter systems interact with each other and with voltage-dependent ... dissolved in saline) before AlCl3 administration; (4) L-NAME group (n = 10) - animals were treated with L-NAME with 1 single dose (1 × 10-4 g dissolved in saline) before saline administration.Using ... L-NAME was immediately injected before the neurotoxin/saline solution. For all treated animals, the injected intracerebral volume was 10 μl and was always injected into the left side. The...
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báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt
... expressionof apoptogenic protein bax, and also the release and translocation of apoptosis inducing factor AIF and cytochrome c from the mitochondria to the nucleus, without altering the subcellulardistribution ... corresponds with apoptosis induction, a criticalparameter impaired in cancer cells, and this induction isselectively exerted in cancer and transformed cell lines,while being less active toward ... bcl-2 in HL-60 cells treated for 48 h with increasing dose of LA. (E) Subcellular distribution of immunoreactive AIF and Cyt C in the cytosol, mitochondria and nucleus in control and 24 and 48...
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Báo cáo khoa học: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria doc
... samplewas treated with proteinase K before being solubilized in digitonin-containing buffer and subjected to BN-PAGE and phosphorimaging. (B)35S-labeled complex IV subunits were incubated with mitochondria ... then be transferred into the maturingcomplex IV.Integration of nDNA-encoded subunits intosupercomplexes in patient mitochondriaUsing digitonin solubilization of mitochondria to visu-alize supercomplexes, ... was treated with proteinase K before being split in two and (A) solubilized in DDM-containing buffer and subjected to BN-PAGE (protease -treated samplesonly), or (B) SDS–PAGE and phosphorimaging....
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Báo cáo khoa học: Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats ppt
... suggest that dietary curcumin and capsaicin individually are protective to LDL oxidationboth in vivo and in vitro, to iron-induced hepatotoxi-city and to carrageenan-induced in ammation. Thesebeneficial ... oxidation both in vivo and in vitro, to iron-induced hepatotoxicity and to carrageenan-induced in ammation. This beneficial effect was higherwhen the two compounds were fed in combination.AbbreviationsAlAT, ... capsaicin (saline-injected); 6, capsaicin (Fe2+-injected);7, curcumin + capsaicin (saline-injected); 8, curcumin + capsaicin(Fe2+-injected).Health protective effects of curcumin and capsaicin...
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Báo cáo khoa học: Chromatin dynamics at DNA replication, transcription and repair pdf
... removing a largerportion of the DNA. In NER, a short oligonucleotideincluding the damaged site is excised by nicking one DNA strand on either side of the damage and removing theintervening DNA ... licensing factor MCM2 [57,58].Perhaps this provides a means to target histone acetylation to chromatin in the vicinity of origins in higher eukaryotes in order to regulate temporal origin firing. ... K79).It will be interesting to learn how the cellular machinerycopes with this issue.Chromatin and DNA repairDespite its protection within the chromatin, DNA is subject to widespread damage through...
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