Báo cáo khoa học: "Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells" potx

... factor-kappa < /b> B (NF-jB) on enterotoxin < /b> staphylococcal < /b> enterotoxin < /b> C1 (SEC1)-induced pyrogenic < /b> cytokine < /b> production < /b> in < /b> human < /b> peripheral < /b> blood < /b> mononuclear < /b> cells < /b> (PBMC). The results indicate that the febrile ... SEC1-stimulated PBMC in < /b> rabbits was in < /b> parallel with the levels of interleukin-...

Ngày tải lên: 19/02/2014, 00:20

... by sublexical information in Chinese. The games aim at implicitly informing players of the Chinese GPC rules, mimicking the process of how infants would apply statistical learning (Saffran ... major formation of Chinese characters, and radicals carry partial semantic information about Chinese charac- ters. Hence, one may use radicals as hints to link the meanings...

Ngày tải lên: 19/02/2014, 19:20

... set of pro and con sentences in online reviews using clue phrases for pros and cons in epinions.com in order to train our system. We applied it to label sentences both on epin- ions.com and ... describes experimental and results and finally, in Section 6, we conclude with future work. 2 Pros and Cons in Online Reviews This section describes how we define...

Ngày tải lên: 20/02/2014, 12:20

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For ... between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and ⁄ or binding of the SH2 kinase...

Ngày tải lên: 06/03/2014, 01:20

... useful model for studying human TP53 mutagenesis is the partial human TP53 knock -in (Hupki) mouse (Jackson Laboratory Reposi- tory designation: 129Trp53 tm ⁄ Holl ) containing exons 4–9 of human TP53 ... experimentally- induced mutation spectra [41]. Thus, mice (and cells derived from them) containing the human TP53 DBD sequence can be used to test hypotheses o...

Ngày tải lên: 06/03/2014, 11:20

... advances in understanding the effect of osmolytes on protein stability, folding and the activity of proteins and enzymes, the relationship between protein stabilization by osmolytes and its con- sequent ... protein stability and activity are not largely coupled in the presence of osmolytes. However, protein stability and activity have...

Ngày tải lên: 07/03/2014, 00:20

... Association for Computational Linguistics Biographies, Bollywood, Boom-boxes and Blenders: Domain Adaptation for Sentiment Classification John Blitzer Mark Dredze Department of Computer and Information ... trained without adaptation, while the gold standard is an in -domain classifier trained on the same domain as it is tested. Figure 1 gives accuracies for all pairs o...

Ngày tải lên: 08/03/2014, 02:21

... (b-cost) of a segmentation candidate. By this, the collocation tends to have priority over the ordi- nary word. The standard and initial value of each segment cost is 2, and it is increased by ... conceptual collocation and IS-/il~ I., Lx/II~|~/~ ~) ~'t~ A~ ni/kosita/kotoha/arimasen: is a functional collocation. In the first example, these collocations are dealt with...

Ngày tải lên: 08/03/2014, 05:21

... adaptive traits Survival of southern red oak in South Car- olina and Mississippi is not source-related. ature on variation of growth and adaptive traits in North American oaks. ... flushing begins in trees of northwest- ern origin, then proceeds ’eastward’ through trees of northern origin to trees of northeastern origin, and al...

Ngày tải lên: 08/08/2014, 19:21

... even in cells lacking the p53 gene (Figure 3B). Conclusions DCQ is a selective cytotoxin in HCT116 human colon cancer cells and its toxicity is independent of p53 and p21. DCQ toxicity is associated ... quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21. Radia...

Ngày tải lên: 09/08/2014, 09:20

... Access Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells Chia-Yuan Liu 1,3 , Hsun-Shuo Chang 5 , Ih-Sheng Chen 5 , Chih-Jen Chen 3 , Ming-Ling Hsu 2 , ... nucleus in a round cell contour. These findings indicated a mitotic arrest at the metaphase was induced by costunolide. Signaling molecules associated with mito...

Ngày tải lên: 09/08/2014, 09:20

... in human soft tissue tumors - a clinicopathological analysis Diana David 1 , Lakshmy M Rajappan 2 , Krishna Balachandran 3 , Jissa V Thulaseedharan 1 , Asha S Nair 1* and Radhakrishna M Pillai 1 Abstract Background: ... percentages of expressed STAT3 and pSTAT3 in all tumor groups. Immunoblot analysis of STAT3 and pSTAT3 in soft tissue tumors STAT3...

Ngày tải lên: 10/08/2014, 10:21

... samples BxPC-3 human pancrea tic cancer cells were maintained in RPMI 1640 medium containing 10% fetal bovine serum (FBS; Gibco BRL). 293T cells were maintained in DMEM containing 10% FBS. Ten samples of pancreatic ... utility of miR-214 as a therapeutic target in human pancreatic cancer remains to be determined. Conclusions MiR-15a and miR-214 were found to be aberr...

Ngày tải lên: 10/08/2014, 22:21

... cathepsin B or cathepsin L protease, Cathepsin B and L treatment of HPV16 increases bindingFigure 4 Cathepsin B and L treatment of HPV16 increases binding. Reporter virus binding was compared in ... cathepsin BFigure 6 Lack of HPV16 Infection in the absence of cathepsin B. HPV16 infection levels in cathepsin B and cathepsin L deficient (-/-) and wild type (+/+) MEF...

Ngày tải lên: 12/08/2014, 04:21