Báo cáo khoa học: "MicroRNA expression profiles in human cancer cells after ionizing radiation" pps

... response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene 2009, 28:2419-2424.12. Maes OC, An J, Sarojini H, Wu HL, Wang E:Changes in MicroRNA Expression Patterns in Human ... Open AccessMicroRNA expression profiles in human cancer cells after ionizing radiationOlivier M Niemoeller*, Maximilian Niyazi, Stefanie Corradini, Franz Zehentmayr, Minglun Li, Kirsten Lauber ... therapeutic interventions, including radiother-apy [8,9]. In fact, microRNAs have been shown to mo d-ulate the radiosensitivity of lung cancer cells in vitro[10] and bre ast cancer cells in vivo...

Báo cáo khoa học: " Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response" potx

... alkylating agents by linking the alkylatingpharmacophore to the DNA-affinity molecules (e.g.,DNA intercalating agents, DNA minor groove binder)[7,8]. In most cases, the DNA-directed alkylating ... thera-peutic efficacy in nude mice bearing human breast MX-1tumors and human glioma in vivo [14]. Interestingly, wefound that obvious tumor suppression was observed in mice and sustained over 70 days ... of human tumors [3,25,26]. Clinical studies also indicatethat delivery of TMZ during radiotherapy increasesFigure 4 Apoptotic effects of BO-1051 in combination with irradiation in glioma cells. U87MG,U251MGandGBM-3wereexposedto200...

Báo cáo khoa học: "MicroRNA expression after ionizing radiation in human endothelial cells" ppt

... up-regulated in several human tumor types including lung, pancreas, p rostateand colon cancer [18]. Matsubara et al. could show thatthe i nhibition of miR-20a can induce apoptosis in lung cancer cells ... shown to induce miRNA expression via the p53 network [12]. Here we investi-gated the miRNA response in EC after ionizing radia-tion. To this end, human EC were irradiated andradiation-induced ... 5:25http://www.ro-journal.com/content/5/1/25Page 4 of 10oncogene BCL-6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006, 9:435-443.22. Vasudevan S, Tong Y, Steitz JA: Switching from repression to activation:MicroRNAs...

Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx

... arthritic inflammation was induced 14 days after intra-articular injection (designated day 0) by intravenousinjection of 200 µg PG-PS. This resulted in monoarticulararthritis involving the joint ... (Continued)Genes upregulated in ankle joints from SCW-induced arthritis in Lewis (LEW/N) ratsAvailable online http://arthritis-research.com/content/7/1/R101R103 expression profiles in joints ... panel including the names and hierarchical clustering order of the individual samples analyzed. Red names are joint tissues from SCW-injected animals, indicating the corresponding time point of...

Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt

... downregulation in malignant T cells requires further investigation. Expression of TNFSF10, BCL2L1, SPP1, and CREBBP genes in BCL11B-siRNA935-treated primary leukemic T cells After obtaining interesting ... target.CREBBP overexpression has been detected in Jurkat cells [21]. However, previous studies h ave not reportedachangeinCREBBP expression in T cell lines after BCL11B-siRNA treatment. In the present ... enhancetheir binding to BCL-2, thereby inhibiting the anti-apop-totic function. Thus, we analyzed the BCL-2 protein expression level by flow cytometry in Molt-4 cells at 72hafterBCL11B-siRNA...

Tài liệu Báo cáo khoa học: Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster doc

... retainedenzymatic activity in these human T-cell lines.Increasing sensitivity to nucleoside analogs in Dm-dNK expressing cells We determined the sensitivity of the untransduced H9and CEM cells ... and H9 cells grown under the following different conditions: in normalculture medium [RPMI containing 10% (v ⁄ v) dialyzedserum, penicillin and streptomycin], in culture medium con-taining 1 ... expressing H9 cells, as found in the same cells grown in dialyzed medium without HU.Effects on mtDNA In the light of the changed dNTP pools in Dm-dNKexpressing H9 cells, we wanted to investigate...

Báo cáo khoa học: "Detecting problematic turns in human-machine interactions: Rule-induction versus memory-based learning approaches" pot

... 1997).RIPPER is a fast rule induction algorithm. Itstarts with splitting the training set in two. On thebasis of one half, it induces rules in a straightfor-ward way (roughly, by trying to maximize cov-erage ... system-knows-baseline. In addition, theof 84.8 is nearly 6 points higher than thatof the relevant, majority-class baseline.The results obtained with RIPPER are shown in Table 3. On the problem of predicting ... sys-tem, usingmachine learning techniques. Their ap-proach also raises a number of interesting follow-up questions, some concerned with problem de-tection, others with the use of machine learningtechniques....

Báo cáo khoa học: Prohibitin is expressed in pancreatic b-cells and protects against oxidative and proapoptotic effects of ethanol pdf

... caused an increase in cleaved caspase-3 in both RINm5F (Fig. 8C) andINS-E1 cells (Fig. 8D). In a different approach, apop-tosis of RINm5F cells was determined by counting freeﬂoating cells (Fig. ... treatmentINS-1E and RINm5F cells were grown in RPMI 1640 med-ium containing 10% fetal bovine serum, 1% penicillin andstreptomycin at 5% CO2and 37 °C. For INS-1E cells, themedium also contained ... Effect of overexpression of PHB on ethanol-induced apopto-sis in INS-1E cells. INS-1E cells were transfected with pCMV6-XL5vector containing the human PHB clone and subsequently incu-bated with...

Báo cáo khoa học: Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA pdf

... Lipofectamine (1.6 lL)was diluted in 50 lL Opti-MEM, incubated for 5 min, thenmixed and incubated for 20 min before addition to cells. After overnight incubation at 37 °CinaCO2incubator,DMEM ... of human PRDX5 in mitochondria of Chinese hamster cells decreases formation of 8-oxoG in mitochondrial DNA[20], but the role of this protein in protecting nuclearDNA from oxidation in human cells ... PRDX5 in silencing of the transcription of heterochromatin.Discussion In this study we found that PRDX5 gene expression in cultured human A549 cells as well as in several other human cell lines...

Báo cáo khoa học: "Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo" docx

... proven effective in inhibiting thefunction of proteins by blocking the activity domain orcritical protein interaction sites. There have beennumerous antibody drugs undergoing pre-clinical andFigure ... canbe pro duced in infinity. In addition, soluble anti-DPK3-svFv was shown to have high specificity for DNA-PKcs in vitro. In this study, expression of anti-DPK3-scFv in HeLa cells increased radiosensitivity, ... DNA-PKcsDNA-PKcs is approximately 470 kD consisting of 4128amino acids. Its C-terminus contains a serine/threonineprotein kinase domain (3719- 4128) [23]. For screeningthe specific anti-DNA-PKcs scFv...

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