Báo cáo khoa học: "MicroRNA expression profiles in human cancer cells after ionizing radiation" pps

... response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene 2009, 28:2419-2424. 12. Maes OC, An J, Sarojini H, Wu HL, Wang E: Changes in MicroRNA Expression Patterns in Human ... Open Access MicroRNA expression profiles in human cancer cells after ionizing radiation Olivier M Niemoeller * , Maximilian Niyazi, Stefanie Corradini, Fran...

Ngày tải lên: 09/08/2014, 09:20

... alkylating agents by linking the alkylating pharmacophore to the DNA-affinity molecules (e.g., DNA intercalating agents, DNA minor groove binder) [7,8]. In most cases, the DNA-directed alkylating ... thera- peutic efficacy in nude mice bearing human breast MX-1 tumors and human glioma in vivo [14]. Interestingly, we found that obvious tumor suppression was observed in mice and sus...

Ngày tải lên: 09/08/2014, 09:20

... up-regulated in several human tumor types including lung, pancreas, p rostate and colon cancer [18]. Matsubara et al. could show that the i nhibition of miR-20a can induce apoptosis in lung cancer cells ... shown to induce miRNA expression via the p53 network [12]. Here we investi- gated the miRNA response in EC after ionizing radia- tion. To this end, human EC were irra...

Ngày tải lên: 09/08/2014, 08:23

... arthritic inflammation was induced 14 days after intra-articular injection (designated day 0) by intravenous injection of 200 µg PG-PS. This resulted in monoarticular arthritis involving the joint ... (Continued) Genes upregulated in ankle joints from SCW-induced arthritis in Lewis (LEW/N) rats Available online http://arthritis-research.com/content/7/1/R101 R103 expression profiles...

Ngày tải lên: 09/08/2014, 06:22

... downregulation in malignant T cells requires further investigation. Expression of TNFSF10, BCL2L1, SPP1, and CREBBP genes in BCL11B-siRNA935-treated primary leukemic T cells After obtaining interesting ... target. CREBBP overexpression has been detected in Jurkat cells [21]. However, previous studies h ave not reported achangeinCREBBP expression in T cell lines after BCL...

Ngày tải lên: 10/08/2014, 21:23

... retained enzymatic activity in these human T-cell lines. Increasing sensitivity to nucleoside analogs in Dm-dNK expressing cells We determined the sensitivity of the untransduced H9 and CEM cells ... and H9 cells grown under the following different conditions: in normal culture medium [RPMI containing 10% (v ⁄ v) dialyzed serum, penicillin and streptomycin], in culture medium...

Ngày tải lên: 20/02/2014, 01:20

... 1997). RIPPER is a fast rule induction algorithm. It starts with splitting the training set in two. On the basis of one half, it induces rules in a straightfor- ward way (roughly, by trying to maximize cov- erage ... system-knows-baseline. In addition, the of 84.8 is nearly 6 points higher than that of the relevant, majority-class baseline. The results obtained with RIPPER are shown in...

Ngày tải lên: 23/03/2014, 19:20

... caused an increase in cleaved caspase-3 in both RINm5F (Fig. 8C) and INS-E1 cells (Fig. 8D). In a different approach, apop- tosis of RINm5F cells was determined by counting free floating cells (Fig. ... treatment INS-1E and RINm5F cells were grown in RPMI 1640 med- ium containing 10% fetal bovine serum, 1% penicillin and streptomycin at 5% CO 2 and 37 °C. For INS-1E cells, the...

Ngày tải lên: 29/03/2014, 08:20

... Lipofectamine (1.6 lL) was diluted in 50 lL Opti-MEM, incubated for 5 min, then mixed and incubated for 20 min before addition to cells. After overnight incubation at 37 °CinaCO 2 incubator, DMEM ... of human PRDX5 in mitochondria of Chinese hamster cells decreases formation of 8-oxoG in mitochondrial DNA [20], but the role of this protein in protecting nuclear DNA from oxidati...

Ngày tải lên: 30/03/2014, 11:20

... proven effective in inhibiting the function of proteins by blocking the activity domain or critical protein interaction sites. There have been numerous antibody drugs undergoing pre-clinical and Figure ... can be pro duced in infinity. In addition, soluble anti-DPK3- svFv was shown to have high specificity for DNA-PKcs in vitro. In this study, expression of anti-DPK3-scFv in HeL...

Ngày tải lên: 09/08/2014, 09:20