Báo cáo khoa học: "Cell death by the quinoxaline dioxide DCQ

Báo cáo khoa học: "Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21" pdf

... even in cells lacking the p53 gene (Figure 3B). Conclusions DCQ is a selective cytotoxin in HCT116 human colon cancer cells and its toxicity is independent of p53 and p21. DCQ toxicity is associated ... quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21. Radia...

Ngày tải lên : 09/08/2014, 09:20

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Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes pdf

... compartments other than lipid droplets. The expression of CIDEC is elevated during the differentiation of adipocytes To gain further insight into the roles of CIDEC in adipocyte differentiation, human ... Expression of CIDEC increased during the differentiation of fetal adipose tissue. (A) Immunohistochemical staining was used to determine the expression of CIDEC...

Ngày tải lên : 23/03/2014, 03:20

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Báo cáo khoa học: Protein expressed by the ho2 gene of the cyanobacterium Synechocystis sp. PCC 6803 is a true heme oxygenase pot

... spectra of the complexes of heme and HOs resemble the spectrum of myoglobin with one exception, the HO of Drosophila melanogaster. In the HO of fruit ﬂy, the iron of heme was not involved in binding ... (dotted-dashed line) complexes. Inset, titration of Syn HO-2 (9 l m) with hemin as monitored by the increase in absorb- ance at 412 nm ()). The increase...

Ngày tải lên : 30/03/2014, 15:20

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Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc

... the levels of interleukin-1b and interleukin-6 in the supernatants. The release of interleukin-1b and interleukin-6, nuclear translocation of NF-jB and its DNA binding activity in the SEC1-stimulated ... signiﬁcant. The maximum elevation of the colonic temperature over the preinjection value (Dt co ) and the fever index, given by the area under the...

Ngày tải lên : 19/02/2014, 00:20

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Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc

... allowing the study of their effect on tumourigene- sis. By introducing the mutation into the humanized TP53 allele rather than wild-type mouse Tp53, the impact of the mutation on the structure and ... chemistry and sequence context play a key role in chemical- and UV-induced mutagenesis of TP53. One of the most important in uences in the TP53 sequence is...

Ngày tải lên : 06/03/2014, 11:20

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Báo cáo khoa học: Functional genomics by NMR spectroscopy Phenylacetate catabolism in Escherichia coli docx

... from the aromatic ring carbons of phenylacetyl- CoA. This indicates that removal of the original C 2 side chain yields a C 6 intermediate via an open-chain C 8 intermediate. The formation of 1 by ... derivative of phenylacetyl-CoA [8]. Fur- ther metabolism of this intermediate appears to be blocked in the paaG mutant, suggesting that the PaaG protein uses this nonaroma...

Ngày tải lên : 23/03/2014, 18:20

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báo cáo khoa học: "Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?" doc

... chemoradiotherapy in technically operable IIa-III esophageal carcinoma is still unresolved. Findings We have read with interest the report from Hurmuzlu and coll [1] on the outcome of induction therapy ... loco-regional disease and exclude distant metastases and c) include a standardized surgical treat- ment with extended lymph node dissection. Only by such trials the role...

Ngày tải lên : 09/08/2014, 01:24

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Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx

... specifically at the ER by binding to the autophagy-inducing protein Beclin-1 [15]. Even though the role of Bcl-2 has been most intensively studied in mitochondria and the ER, Bcl-2 also localizes to the ... mechanisms of ciPCD are just beginning to be unraveled, e. g. by the recent identification of RIP3, enzymes of the energy metabolism, Nox1, CYLD, Bmf, and c...

Ngày tải lên : 09/08/2014, 10:20

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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

... promotion of malignant cells. The fundamental function of miRNAs is to regulate their targets by direct cleavage of mRNA or by inhibi- tion of protein synthesis. On the one hand, computa- tional ... reporter vectors containing mutations of the miR-23a binding site were used in the ﬂuorescent reporter assay. The reporter vector containing a mutation of the ﬁr...

Ngày tải lên : 18/02/2014, 04:20

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Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt

... nonspe- ciﬁc, disruptive effect on the binding of antibodies to antigens such as laminin and myosin (data not shown). Both HB-19 and lactoferrin bind to the C-terminal RGG domain of nucleolin. Therefore, ... antigens laminin and myosin (data not shown). Further perturbation experiments were carried out using the protein lactoferrin. Lactoferrin, an iron- binding protein of...

Ngày tải lên : 19/02/2014, 05:20

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