Báo cáo khoa học: "MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells" pot

... the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells ... 5:100 http://www.ro-journal.com/content/5/1/100 Page 7 of 8 RESEA R C H Open Access MicroRNA-17-92 significantly enhances radioresistance in human mantl...

Ngày tải lên: 09/08/2014, 09:20

... ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the FYRC domain and the ... denominator in all different MLL rearrangements is disruption of the MLL protein in a region that prevents any subsequent pro- tein–protein interaction between the resulting MLL fusion proteins....

Ngày tải lên: 16/02/2014, 14:20

... by protamines [64,65], but there is no hint in the literature on how it could affect in vivo chromatin remodelling in spermatids. The recent identification of a new bromo- domain-containing testis ... [82,83] enriched in transcriptionally active regions [32]. The localization of H 3.3-containing chromatin has not yet been determined in mammalian germ cells, but in Drosophila, H3.3...

Ngày tải lên: 07/03/2014, 16:20

... 19,21]. To investigate SSA–TCR binding affinity, we expressed these molecules in high yield prokaryotic systems that allow u s to obtain enough recombinant protein t o conduct binding studies. In order ... two globular domains: a small N-terminal domain w ith an O B fold (Ôoligosaccharide/oligonucleotide-bindingÕ), and a large C-terminal domain with a b-grasp motif [10,11]. The TCR binding...

Ngày tải lên: 07/03/2014, 16:20

... remaining failures resulted from errors in the creation of the tagged vocabulary (5), non-definitien dictionary lines incorrectly labeled as definition texts (53, and non-noun definitions inconecfly ... relational triples. Finding relational triples by text processing As the performance statistics above show, parsing is painfully slow. For the simple business of finding and writing...

Ngày tải lên: 08/03/2014, 18:20

... cystatin C uptake in human cells. We initially chose cell lines with different characteristics such as a human epidermoid carcinoma cell line (A-431) and a human mammary tumour cell line (MCF-7). In ... cysteine inhibitory capacity of cells. The human cancer cell lines chosen included one epidermoid carci- noma cell line, three mammary tumour cell lines and one human...

Ngày tải lên: 16/03/2014, 06:20

... pre- warmed in a water bath at 37 °C) was dispensed into each well and incubated for 15 min (prewarming fixative is critical to maintaining cell integrity). After 15 min, the plates were inverted ... Stimulation of cells was performed at 10-min intervals for 400 min with IL-1a. After 400 min, the plates were inverted to remove media into a dish containing Virkon disinfectant to destroy cel...

Ngày tải lên: 16/03/2014, 11:20

... proteins such as albumin or lipoproteins, thus lowering their uptake rate into the cells and decreasing their biological activity. Therefore, all experiments were carried out with cells growing in ... those obtained with other cell lines such as Raji and KB cells, in which a pronounced decrease in the incorporation of [ 14 C]choline into PC was paralleled by an increase in the degra...

Ngày tải lên: 17/03/2014, 11:20

... pro- vided insights into important enzyme–substrate interac- tions. For example, molecular modeling of HC interacting with angiotensin (Ang) I has led to conclu- sions regarding the S2¢ binding site ... for potential in vivo substrates is being performed using bioinformatic screening. However, the identification of these substrates may be challenging, mainly because of the ability of HC to i...

Ngày tải lên: 22/03/2014, 21:21

... adipophilin (Fig. 4B) and by Oil Red O staining (Fig. 5E,F). In cells cultured in the absence of VLDL (control cells), nominal diffuse cytoplasmic adipophilin staining was observed (Fig. 4A); in the ... adipophilin does not elevate cellular TG by protecting it from cellular lipases. However, because these results were obtained using an indirect method (triacsin C inhibition) affecting t...

Ngày tải lên: 23/03/2014, 10:21