Báo cáo khoa học: "Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients" ppt

... 281:1674-1677. doi:10.1186/1748-717X-5-85 Cite this article as: Pinar et al.: Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients. Radiation Oncology 2010 ... 2 of 5 RESEARC H Open Access Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced...

Ngày tải lên: 09/08/2014, 09:20

... anthracycline-containing chemotherapy in the Cancer International Research Group 006 clinical trial of trastuzumab (herceptin) in the adjuvant setting [abstract]. 28th Annual San Antonio Breast Cancer ... Elledge R, Mohsin SK: Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIalpha for anthracycline, chemotherapy in locally advanced breast cancer....

Ngày tải lên: 10/08/2014, 22:20

... by interact- ing with and interfering with Ku70–Ku80 [21,22]. Considering that epidermal cells are mostly exposed to environmental insults, and that both AP-1 [10–12] and CLU [20] are induced and ... NF-jB-dependent genes induced by proteinuria and identified using DNA microarrays. Clin Exp Nephrol 12, 181– 188. 77 Perkins ND (2007) Integrating cell signalling pathways with...

Ngày tải lên: 16/03/2014, 02:20

... why sarcomas are likely to be induced in heavily irradiated tis- sues. A relationship between initial RT doses and second head and neck malignancies was unknown in this study. The RT doses employed in ... second cancer was 13.9 years (range, 8.7 to 22.7 years). Two of the patients (1 with gum cancer and 1 with maxillary sinus cancer) died of the sec- ond cancer. The re...

Ngày tải lên: 09/08/2014, 10:20

... statin -induced apoptosis to be significantly inhibited (Figure 3B-D). Statin -induced decrease in the expressions of phosphorylated ERK1/2 and Akt To identify the molecules involved in statin -induced apoptosis, ... These find- ings indicate that 2 μMand2.5μM of fluvastatin and simvastatin, respectively, are within the peak plasma values of fluvastatin or simvastatin that ar...

Ngày tải lên: 10/08/2014, 10:21

... of serine proteinases by digesting various serpins (serine proteinase inhibitors) [11], and the growth factor activity of insulin-like growth factor (IGF) by the ability to degrade IGF binding ... also hide the epitopes that are normally involved in the APMA -induced activation of MMP-9, and expose epitopes that results in an APMA- induced inhibition of the calcium -induced acti...

Ngày tải lên: 17/03/2014, 10:20

... carcinoma: incidence and determinants. Br J Radiol 1992, 65:710-714. 6. Rubenstein LJ: Radiation changes in intracranial neoplasms and the adjacent brain. In Book Radiation changes in intracranial ... led to a dwindling incidence of TLN. Yet, it still holds great significance due to its incapacitating feature and the difficulties faced clinically and radiologically in dist...

Ngày tải lên: 09/08/2014, 09:21

... groups. Results Radiation -induced Acute and Chronic Skin Reaction Acute skin reactions were initially similar for the TSK and C57BL/6 parental mouse strains. For example, skin inju- ries up to six weeks following ... Gy. Radiation -induced Leg Contraction Measurements of radiation -induced leg contraction in TSK and C57BL/6 mice starting at two months and contin- uing to the end...

Ngày tải lên: 09/08/2014, 09:22

... signaling pathway in a subset of GBM cell lines. IR -induced Akt activation was dependent upon the presence of serum factors, and could be inhibited by the EGFR inhibitor. Inhibiting PI3K, EGFR and ... rapamycin pathway regulates insu- lin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mo...

Ngày tải lên: 09/08/2014, 10:20

... misshapen, and clumpy (Fig. 1B), phenotypes indicating a loss of cell wall integrity and seen with other gpi mutants [28]. Because GPI-anchored proteins are the only known proteins covalently linked ... covalently linked to inositol in yeast [29,30], we examined the ability of Ybr004cp-depleted cells to incor- porate [ 3 H]inositol into proteins. The ybr004cD-pGAL- YBR004c strain was...

Ngày tải lên: 07/03/2014, 16:20