Báo cáo khoa học: " The role of radiotherapy in multimodal treatment of pancreatic carcinoma" ppt

... knowledge regarding the role of radiotherapy in the treatment of pancreatic ductal adenocarcinoma (PDAC). The results of meta-analyses, phase III-studies, and phase II-studies using chemoradiotherapy ... original work is properly cited.Review The role of radiotherapy in multimodal treatment of pancreatic carcinomaThomas B Brunner* and Martin Scott-BrownAbstract Pancreatic ductal carcinoma ... technique of chemoradiotherapy may explainthis difference. The improved radiotherapy techniqueemployed in the RTOG trial is reflected in the reduction of local recurrence rates being 25% in the RTOG...

Báo cáo khoa học: "The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study" doc

... cancers.When the annual incidence of CRCs in 2005 was com-pared to that in 1999, there was an increase of 150% in men and 135% in women; CRC was shown to be one of the most sharply increased malignancies ... 1994,343:1405-1410.17. Thomas PR, Lindblad AS: Adjuvant postoperative radiotherapy andchemotherapy in rectal carcinoma: a review of the GastrointestinalTumor Study Group experience. Radiotherapy and Oncology ... The top of the treatment field wasplaced at the L4-5 junction, with the lateral borders 1-2cm outside the bony pelvis, and the inferior margin at 4cm below the tumor. A total dose of 41.4...

Tài liệu Báo cáo khoa học: The role in the substrate speciﬁcity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx

... by deter-mining the in uence on the glycone binding of the Sfbgly interactions with the aglycone. Thus, the effect of the alteration of the glycone structure in the stabil-ity of the ESàcomplex ... positioning within subsite )1 [13].Nevertheless, details about the role of different resi-dues of the aglycone-binding site in the stabilization of ESàand the interdependence between the binding ... F179 is part of the aglycone-binding site of Cpbgly [22]. In order to com-pare the aglycone-binding sites of these b-glycosidases, the effect of the aglycone size on the binding of severalalkyl...

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... detected at the dimerinterface of the models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure ... at the dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex-changing and exchanging HHP-RNase were prepared start-ing from 1Z7X. The ... through the exchange between subunits of either their N-ter-minal, or their C-terminal ends [33–35]. We foundthat the behavior with the model membrane of the dimer in which the C-terminal ends...

Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs,thereby releasing the nucleocapsid into the lumen of these vesi-cles. Then, the capsid uses these intra-endosomal ... milddevelopmental delay. The protein defective in this disorder is alsoa NHEJ protein. The distinct clinical features of the patients willbe discussed in the context of the protein function.3.4 Diabetes, ... Mutations in the ERCC1 gene induce a distinct set of accelerated ageing features,with a rate of onset depending on the severity of the mutation. The correlation between repair defect severity and clinical...

Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

... proposed X-linkage.Sequence analyses of the ESSS cDNA in these mutantsrevealed chain termination mutations. In two of thesemutants the protein i s truncated at the C-terminus of the targeting sequence; ... likely that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... as a nother identiﬁcation of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex IIand against the Rieske protein of complex...

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafﬁcking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efﬁcient GABA-uptake activity of the GABA transporter pptx

... N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... results in reduction of the stability of GAT1 In order to study the in uence of the N-glycosylationand N-linked oligosaccharides on protein stability, the intracellular decay time of the GAT1, ... for the stability of this protein,but the terminal structure of the N-glycans is not.Defective N-glycosylation reduces the trafﬁcking of GAT1 to the plasma membrane In order to study the in uence...

Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf

... frag-ments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR. The remaining portions of the polylinker introduced leucine and valine residues N-ter-minal to the MUC3 and ... according to the intensity of M2-reactivespecies in the corresponding whole cell lysate.Molecular modeling of SEA domain of MUC1 The composer and biopolymer modules of the sybyl 6.91software ... and the cytoplasmic tail. These two parts of the protein remain associated by noncovalent interac-tion, probably involving sequences within the SEAdomain. The contribution of ﬁve different aminoacids...

Tài liệu Báo cáo khoa học: "The Role Of Focussing in Interpretation of Pronouns " pdf

... Processing. Dept. of Computer Science TR-70, Rutgers University, New Brunswick, N.J. Reinhart, T;mya [1976] The Syntactic Domain of Anaphora. unpublished Ph.D. dissertation, Department of Foreign ... and LinBuistics, M.I.T. Rieger, Charles J. [1974] Conceptual Memory: A Theory and Compufer Program for Processing Ihe Meaning Content of Natural Language Utterances. Stanford Artificial Intelligence ... [1979] To,'ards a Computational Thmr 7 of Definite Anaphora Comprehension in £nglish Discour~. unpublished Ph.D. disseration, Electrical Engineering and Computer Science, M.I.T. Webber,...

Tài liệu Báo cáo khoa học: "The Role of Initiative in Tutorial Dialogue" pdf

... using changes in initiative as a starting point; thesechanges were taken as marking either a segment endpoint or the beginning of a nested segment.tion following a question takes initiative. ... correlation, we hypothe-5Walker and Whittaker define interruptions as taking the initiative without invitation. It does not refer to interrupting the utterance of the other speaker.72(Rosé ... overview of the ev-idence in favor of Socratic tutoring as well as de-scribing an opposing viewpoint supporting a tutor-ing style referred to as didactic. Here, rather thandrawing out the answer...

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