Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... thedestruction of cartilage. In this study, we investigate the role of synovial macrophages and their main proinflammatory cytokines, interleukin (IL)-1 and tumour necrosis factor-alpha (TNF-α), in driving ... player in promoting the production of inflammatory and degradative mediators in the OA synovium. In particular,our results indicate a role for both TNF-α and IL-1β in driving inflammatory responses ... osteoarthritis synovitis and influencing the production of other pro- and anti -inflammatory cytokines, production of matrix metalloproteinases, and expression of aggrecanases in theosteoarthritis synovium....
- 12
- 325
- 0
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction.To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute 45% of the totalunitary free energy of binding of cystatin A to ... cathepsin B,demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may bedirectly involved in the interaction with cathepsin B byproviding hydrophobic...
- 10
- 533
- 0
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of theenzyme for PAA and derivatives thereof, while maintainingthe hydrophobicity of the binding site.To ... (kcat/Km)forp-hydroxyphenylgly-cine methyl ester and phenylglycine methyl ester that weresimilar to the wild-type values, whereas the specificity con-stants for p-hydroxyphenylglycine amide and phenylglycineamide ... methyl ester or the amide asacyl donor.It appeared that 6-APA and 7-ADCA were able toefficiently deacylate the phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF24A, as indicated by, respectively,...
- 8
- 561
- 0
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... indicatingthat, in the absence of coenzyme M, zinc is probablycoordinated by a single sulfur ligand and three oxygen ornitrogen ligands. In the presence of coenzyme M, one(N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In theHis237 fi Ala and Cys239 fi Ala mutants, coenzyme Malso seemed to bind efficiently by ligation to zinc indicatingthat some aspects of the zinc ligand ... &Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. J. Am. Chem Soc. 120,8410–8416.15....
- 7
- 464
- 0
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) and the carboxylate of the a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 and ... ternary com-plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to primesubstrate oxidation. In the case of DAOCS it has been previously shown...
- 5
- 462
- 0
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... delivery. The frequency of developingatopic dermatitis in the offspring was significantlyreduced by 2, 4, and 7 years [26-28], by 50%, 44%, and 36% respectively.Similar studies have yielded ... stemmed from the fact that they have beenshown to reduce inflammatory cytokines and improveintestinal permeability in vitro. Such effects would bedesirable in treating allergic disorders. Therefore, ... in Estonian and Swedish infants. Clin Exp Allergy 2005, 35(2):153-9.12. Bjorksten B, et al.: Allergy development and the intestinalmicroflora during the first year of life. J Allergy Clin Immunol2005,...
- 7
- 560
- 0
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-matory therapy. ... their role in bone metabolism and repairremains unclear.Review of the evidenceTo determine the role of COX-2 in bone repair, investiga-tors have studied fracture healing in animal models of COX-2 ... critical role of COX-2 in mesenchymal cell differentiation during skeletal repair.Using COX-1-null and COX-2-null mice, they demon-strated the essential role of COX-2 in both endochondral and intramembranous...
- 3
- 475
- 0
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... evidence for hypoxia in inflammatory and destructive joint disease, and discusses theinterplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... intracellulardomain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated ... vivo in animal models. A clinical trial of 2-methoxyestradiol is planned in RA, and this may yield furtherinsight into the links between hypoxia, angiogenesis, inflammatory cell trafficking and...
- 9
- 499
- 0
Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx
... asdescribed earlier [9,10], the increased expression of RANKL and RANK within synovial inflammatory tissue[30–32], and the fact that many proinflammatory mediatorspresent in the synovial membrane, such ... consequently lead to increasing inter-est in the role of osteoclasts in local bone erosion that isdriven by the hypothesis that synovial pannus makes useReviewThe role of osteoprotegerin in arthritisGeorg ... page of themanuscript published by Anton Weichselbaum in the Archives forPathology, Anatomy, Physiology and Clinical Medicine in 1878. (c)Title of the manuscript, meaning “The finer changes of...
- 7
- 343
- 0
Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... organization of bone and other mineralized tissues and the mechanism of calcifi-cation. In: Handbook of physiology, endocrinology, parathyroidgland. Edited by Aubarch GD. Washington: American Physiologi-cal ... 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc-tase enzyme. These include naturally occurring lovastatin,chemically modified simvastatin and pravastatin [1–3] and the synthetically derived ... Bone 1995, 17:71s-75s.8. Wozney JM, Rosen V: Bone morphogenetic proteins. In: Physi-ology and Pharmacology of Bone. Edited by Mundy GR and Martin TJ. New York: Springer–Verlag; 1998:725-748.9....
- 4
- 392
- 0
Từ khóa: the role of simple sugars and other factorsbáo cáo y họcbáo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenrole of neuropeptide y on the maintenance of self renewal and proliferation of human embryonic stem cellsenos uncoupling in cardiovascular diseases the role of oxidative stress and inflammationthe role of teachers schools and communities in quality educationexplain the role of art music and dance in african societythe role of students attitudes and motivation in second language learning in online language coursesthe role of sound music and sound effect in the film industrythe role of oxidative stress and inflammation in dry eye diseasethe role of effective communication and interpersonal interaction in health and social careBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt nam