Báo cáo y học: "Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis" ppsx
Báo cáo y học: "Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis" ppsx
... detailed analysis of similar disease pathways operating during early, intermediate and late stages of the development of human arthritis, although they will not be identical to those of RA. On the other ... B cells with the antibody rituximab acting via Review Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of art...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis" potx
... 42.2 years, and mean disease duration was 10.9 years. A total of 288 patients (91.4%) entered the open-label extension phase of the study. Of these 288, 236 (81.9%) had data for three years beyond ... Visvanathan S, Baker D, Goldstein N, Heijde D van der, Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group: Efficacy and safety o...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx
... of the drug is hydrogen-bonded to the two O2 atoms of the thymine bases of the central AT steps. Nitrogen atoms N3(D) and N7(D) bridge N3(adenine) and O2(thymine) atoms of opposite strands. Furthermore, ... electron density, whereas the rest of the drug molecule fits these maps nicely (Fig. 2B). Also the temperature factors of these two atoms are much higher tha...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps
... the Diagnosis, Therapy and Management of Hereditary Angioedema is reviewed in light of the newly published phase III Clinical trials for prevention and therapy of HAE. Management approaches and ... type III HAE) with the defec ts yet to be identified. The pathophysiology of HAE-C1INH types I and II appears to relate to bradykinin resulting in angioedema. HAE may pres...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase" doc
... contributed to the prep- aration of the manuscript, and undertook the statistical analy- sis. HF, PL, and JCF evaluated and interpreted the data and assisted with the preparation of the manuscript. ... the apoptosis process elicited by HNE could vary in different cell types due to changes in the availa- bility or sensitivity of specific regulatory pathways that a...
Ngày tải lên: 09/08/2014, 13:21
Báo cáo y học: " Adjuncts or adversaries to shared decision-making? Applying the Integrative Model of behavior to the role and design of decision support interventions in healthcare interactions" pps
... constructs of four theories of behavior that have been applied in many health contexts over the past 30 years. [21]. These include the Theory of Reasoned Action, the Theory of Planned Behavior, the Health ... populations of patients may vary with regard to beliefs underlying their behaviors and the interrelationships between the central constructs of the theory. [2...
Ngày tải lên: 11/08/2014, 05:21
Báo cáo khoa học: "Embryonic Intermediate Filaments, Nestin and Vimentin, Expression in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis" pdf
... finally, spontaneous recovery. These steps are matched by an inflammatory response in the CNS, which is cha- racterized by the infiltration of T cells and macrophages, and the activation of microglia ... if any inflammatory cells in the spinal cords of rats immunized with CFA. At the peak stage of EAE (day 14 PI), a large number of inflammatory cells infiltrated the...
Ngày tải lên: 07/08/2014, 17:22
Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... cytotoxic T-lymphocyte antigen-4 (CTLA-4). The traditional view of the function of CTLA-4 is that it is upregulated upon stimulation of the T cells and attenuates the response (top). The newly ... for the activation of the cell cycle machinery; the IL-2 signal induces the degradation of the cell cycle inhibitor p27 and expression of G1- kinases, which ultim...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
... Pawlotsky is currently an Associate Editor of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), and of Current Hepatitis Reports, and a member of ... relative contra-indications to therapy, and the patient’s willingness to be treated. The HCV genotype should be systematically determined before treatment, as it d...
Ngày tải lên: 02/11/2012, 09:56
Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
... occupation of the E 2 state. The s everely impaired ADP-dependent dep hosphorylation indicates that also the E 1 state of the mutant differs from that of the wild-type. Interestingly, the nearby ... Quantitation of the inten sity of monomer and d imer bands. The data has been normalized as above. (C) The effect of 30 l M Zn 2+ on the P i -phosphorylation of...
Ngày tải lên: 17/03/2014, 17:20