Báo cáo y học: "Novel self-epitopes derived from aggrecan, fibrillin, and matri" ppt

... following cytokineswere measured: IL-1α, IL-1β, IL-5, IL-10, IL-12, IL-18, tumornecrosis factor-α (TNF-α), and IFN-γ.Cytokine analysis by lymphocyte intracellular staining and flow cytometryT-cell ... Carducci 15, 92100 Milan, Italy6Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The NetherlandsCorresponding author: ... of major histocompatibility complex(MHC) genotype. The peptides derived from aggrecan, fibrillin, and matrix metalloproteinase (MMP)-3 yielded the highestfrequency of T-cell proliferative responses...

Báo cáo khoa học: Novel a-conotoxins from Conus spurius and the a-conotoxin EI share high-afﬁnity potentiation and low-afﬁnity inhibition of nicotinic acetylcholine receptors doc

... the N-ethylsuccinimidocysteinesby hydrolysis [7]. Selected peptides were sequenced toreveal the positions of the alkylated cysteines. The phe-nylthiohydantoin (PTH) derivative of N-ethylsuccini-midocysteine ... N-ethylsuccini-midocysteine elutes between PTH-Pro and PTH-Metin the HPLC system of the sequencer employed. Thepresence of alkylated cysteines at positions 4 and 17 insome peptides, and at positions 3 and ... PC system.Determination of disulﬁde bridgesThe connectivity of the cysteines of toxin SrIA was deter-mined by partial reduction with Tris(2-carboxyethyl) phos-phine hydrochloride and alkylation...

Báo cáo y học: "Novel therapies for treatment of gout and hyperuricemia" pot

... inter-mediate form 5-hydroxyisourate, and subsequent hydrolysisof this produces 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazo-line, which is decarboxylated to S-(+)-allantoin [63]. Theenzymes carrying out ... to marked dampening by thenormal abundance of catalase on erythrocytes [51,59,60] and potentially by other plasma antioxidant defenses. Yetmethemoglobinemia and/ or hemolysis have been unequivocalindicators ... with tophi can achieve eliminationof tophi by 2 years, and approximately 70% by 5 years [49].Quality of life parameters have been favorably impacted byextended febuxostat treatment in uncontrolled...

Báo cáo khoa học: Novel aspects of calmodulin target recognition and activation pptx

... 396–402.113. Drum,C.L.,Shen ,Y. ,Rice,P.A.,Bohm,A.&Tang,W.J.(2001)Crystallization and preliminary X-ray study of the edema factorexotoxin adenylyl cyclase domain from Bacillus anthracis in ... catalyticactivity of the enzyme approximately 1000-fold. Surpris-ingly, the activation of the enzyme is not achieved bydramatically changing the architecture of the active site, norby removing ... suggested to be initiated by the loss of Ca2+ions from the N-terminal CaM lobe, likely followed by loss ofCa2+ from the C-terminal lobe and subsequently followedby rapid loss of the peptide...

Báo cáo y học: "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis" pdf

... together with binding to their cognate ligands.Importantly, ASV derived from VEGF receptor type 1 and Tie1, and to a lesser extent from VEGF receptor type 2 and fibroblastgrowth factor receptor ... by decreased jointinflammation and destruction.Conclusion The present study shows that unique ASV derived from receptors that play key roles in angiogenesis – namely,VEGF receptor type 1 and, ... (c), and (e) )and paw thickness measured by calipers ((b), (d), and (f))were recorded daily. Data were analyzed by two-way analysis of variance versus untreated mice (Table 3). (a) and (b) Mice...

Báo cáo y học: " Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effect" potx

... themanuscript.XZ: Performed confocal microscopy and par-ticipated in study and conjugate design and drafting themanuscript.SG: Performed synthetic and quality controlchemistry and participated in drafting ... manuscript.SP:Performed synthetic and quality control chemistry.OD:Performed HIV and general toxicity studies.MJL: Partici-pated in study and conjugate design and critically review-ing manuscript.ABR: ... the lymphatic and centralnervous systems (CNS) [38,39]. While its low and varia-ble bioavailability is primarily attributed to metabolismby cytochrome P-450 3A, recent results published by ourgroup...

Tài liệu Báo cáo Y học: Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin potx

... data on phyllokinin (braykinyl-isoleucyl-tyrosine-0-sulphate) and bradykinyl-isoleucyl-tyrosine. Br.J.Pharmacol.27, 479–485.16. Yasuhara, T., Hira, M., Nakajima, T., Yanaihara, N. &Yanaihara, ... This sensitivity is well within the capabilityof the ES-MS system employed.The primary structural diversity displayed withinamphibian skin bradykinins may not simply be due tophylogenetic differences ... bioactivity and the lack of information onbradykinin receptor subtypes and pharmacology inamphibians, may mean that, in the past, inappropriatebio- and/ or immuno-assays have been employed to...

Báo cáo khoa học: Novel cathelicidin-derived antimicrobial peptides from Equus asinus docx

... Lai3 and Haining Yu1,21 College of Life Sciences, Hebei Normal University, Shijiazhuang, China2 School of Life Science and Biotechnology, Dalian University of Technology, China3 Key Laboratory ... withgold, they were analysed using a Hitachi S-4800 SEM.Haemolysis, serum stability and the effect of pHon antimicrobial activityHaemolysis assays were conducted as previously described[25]. ... BiotechnologyInformation.CD spectroscopyThe peptide used for the bioactivity test and CD spectros-copy was synthesized by the peptide synthesizer GLBiochem (Shanghai, China), and puriﬁed...

Báo cáo y học: "introduction to special issue on Eye and Zoonosis – from the guest editors"

... http://www.medsci.org 117American Journal of Ophthalmology: Delair E, Monnet D, Grabar S, Dupouy-Camet J, Yera H, Brézin AP. Respective roles of acquired and con-genital infections in presumed ocular ... toxoplas-mosis. Am J Ophthalmol 2008;146:851-5). • Optical Coherence Tomography in ocular toxoplasmosis • Usefulness of vitrectomy in the treatment of ocular toxoplasmosis • Update on the treatment ... toxoplasmo-sis. We hope that this special issue will be interesting to readers and provides researchers with timely up-date on various topics in this important field. Conflict of Interest The...

Tài liệu Báo cáo Y học: Novel complexes of mammalian translation elongation factor eEF1AÆGDP with uncharged tRNA and aminoacyl-tRNA synthetase potx

... werepurchased from Pharmacia. Bio-Gel HTP hydroxylapatitewas from Bio-Rad. [a-32P]ATP, [14C]phenylalanine and [3H]GDP were purchased from Amersham. CTP, GDP,phosphoenolpyruvate and phosphoenolpyruvate ... kinasewere from Sigma. tRNA nucleotidyltransferase was isolated from yeast as described [17]. Bovine catalase was from Serva, rabbit glyceraldehyde-3¢-phosphate dehydrogenase(GADPH) was from Boehringer ... °C. The carboxymethyl dextran matrix of the sensorchip was activated by a 30-lL injection of the mixtureof 0.2M1-ethyl-3-[(3-dimethylamino)propyl]carbodiimide and 0.05MN-hydroxysuccinimide...

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