Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx
Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx
... question remains: if the main IGF-1R signaling pathway is dowregulated in OA Obs, how can we explain the increase in subchondral bone remodeling in OA bone tissue? Maybe the IGF -1 pathway is not ... 2 Effect of insulin-like growth factor (IGF) -1 on alkaline phosphatase activity in osteoarthitis (OA) osteoblastsEffect of insulin-like growth factor (IGF) -1 on a...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... interleukin 1 induced destruction of artic- ular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo. Ann Rheum Dis 19 93, 52 :18 5 -19 1. 10 . ... 2 Staining of various transforming growth factor (TGF)-beta signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling mo...
Ngày tải lên: 09/08/2014, 07:20
Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc
... protein kinase B; caAKT, constitutively active form of AKT; DM, differentiating medium; GM, growth medium; IGF -1, insulin-like growth factor 1; IGFBP5, insulin-like growth factor 1- binding protein; ... that insulin-like growth factor 1 (IGF1)-induced hypertrophy of myoblasts notably increa- ses Neu2 synthesis by activation of the phosphatidylinositol 3-kinase/AKT/ ma...
Ngày tải lên: 19/02/2014, 06:20
Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... J Biol Chem 19 96, 2 71: 14 910 -14 915 . 20. Yamaguchi Y, Mann DM, Ruoslahti E: Negative regulation of transforming growth factor- beta by the proteoglycan decorin. Nature 19 90, 346:2 81- 284. 21. Droguett ... J Clin Pathol 2007, 12 8 :11 2 -11 7. 36. Simeone AM, Nieves-Alicea R, McMurtry VC, Colella S, Krahe R, Tari AM: Cyclooxygenase-2 uses the protein kinase C/inter- leukin-8/uro...
Ngày tải lên: 09/08/2014, 10:22
Báo cáo y học: "Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice" pps
... activity b Masking c 1 C57BL/6J + 3 015 4 1. 82 99.33 2 C57BL/6J + 379 51 0.28 99.45 3 C57BL/6J + 44485 0.86 97.35 4 C57BL/6J Wnt3a vt/vt 23509 1. 43 99.72 5 B6 .12 9 F1 + 510 14 1. 44 95.82 6 B6 .12 9 F1 + ... Egfr wa2/wa2 319 97 0.55 97.97 12 C57BL/6J Egfr wa2/wa2 3 816 5 1. 95 80.49 13 C57BL/6J Egfr wa2/wa2 35 818 0.98 99.37 14 C57BL/6J Egfr wa2/wa2 37774 0.39 99.27 15 C57BL/6J...
Ngày tải lên: 10/08/2014, 09:20
Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... 26 February 2 010 , accepted 2 March 2 010 ) doi :10 .11 11/ j .17 42-4658.2 010 .07635.x Insulin like growth factor- 1 (IGF -1) is established as an anabolic factor that can induce skeletal muscle growth by activating ... through density gradient ( MI:0029) l MINT-7 712 211 , MINT-7 712 236, MINT-7 712 313 , MINT-7 712 323: Tsc1 (uniprotkb:Q9EP53) physically interacts ( MI:0 915 )wi...
Ngày tải lên: 15/03/2014, 11:20
Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis" pps
... Louis CA, Henry WL Jr, Reichner JS: HIF -1 expression in healing wounds: HIF- 1alpha induction in primary inflammatory cells by TNF-alpha. Am J Physiol Cell Physiol 2000, 2 81: 19 71- 1977. 26. Feldser ... 15 ±3 18 ±4 0. 01 16 ±3 17 ±4 0.46 % PD-ECGF lin. cells 51 14 68 ± 21 0. 01 55 18 66 ± 21 0 .14 % PD-ECGF str. cells 30 17 49 ± 26 0. 01 34 ± 18 47 ± 21 0 .13 % bcl-2 5 ±8...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo khoa học: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications" pptx
... 2006 Radiation Oncology 2006, 1: 11 doi :10 .11 86 /17 48- 717 X -1- 11 Received: 26 January 2006 Accepted: 02 May 2006 This article is available from: http://www.ro-journal.com/content /1/ 1 /11 © 2006 Zimmermann ... segment, and an intracellular tyrosine kinase domain. Binding to EGFR by its natural ligands, mainly EGF or transforming growth factor alpha (TGF-α) results in a con-...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Giantin is the major Golgi autoantigen in human anti-Golgi complex sera" pptx
... 11 (27.5) 8 /11 (72.7) 3 /11 (27.3) P3, aa 14 35–2204 (769 aa) 11 (27.5) 7 /11 (63.6) 4 /11 (36.4) P4, aa 2 019 –2568 (549 aa) 7 (17 .5) 3/7 (42.9) 4/7 (47 .1) P5, aa 2550–2843 (293 aa) 15 (37.5) 15 /15 ... protein, GM130. J Cell Biol 19 95, 13 1 :17 15 -17 26. 16 . Munro S, Nichols BJ: The GRIP domain: a novel Golgi-targeting domain found in several coiled-coil proteins. Curr Biol...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression" pdf
... tissues. In contrast, COX-2 is highly inducible by serum, growth factors, lipopolysaccha- rides, and cytokines, especially interleukin -1 (IL -1) , in cer- tain cell types involved in inflammatory processes, ... arthritis. Arthritis Rheum 19 91, 34 :11 25 -11 32. 2. Dinarello CA: Interleukin -1 and tumor necrosis factor: effector cytokines in autoimmune diseases. Semin Immunol...
Ngày tải lên: 09/08/2014, 01:23