Báo cáo y học: "Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β" docx

... 2002 Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field Lucilia Pereira-Mourie ` s 1 , Maria-Jose ´ Almeida 1,3 , ... Amino acid compositions (mole percent) of the water -soluble matrix, water-insoluble matrix, the EDTA -soluble matrix and the EDTA- insoluble...

Ngày tải lên: 21/02/2014, 01:21

... 2002 BIGH3 (TGFBI) Arg124 mutations in uence the amyloid conversion of related peptides in vitro Implications in the BIGH3- linked corneal dystrophies Clair-Florent Schmitt-Bernard 1,2 , Alain Chavanieu 3 , ... decrease in the formation of amyloid fibrils, suggesting the importance of the hydropho- bic NH 2 -end of the peptides. In...

Ngày tải lên: 21/02/2014, 01:21

... carotenoid pathway to b-carot ene proceeds via three enzymatic steps carried out by the enzymes phytoene synthase, phytoene dehydrogenase and lycopene cyclase. The enzyme phytoene dehydrogenase is able ... organi- zation of the P. blakesleeanus phytoene dehydrogenase. Keywords: carotenoid; phytoene dehydrogenase; i nterallelic complementation; Phycomyc es blakesle...

Ngày tải lên: 22/02/2014, 04:20

... Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae Stuart M. Ingleston 1 , Mark J. Dickman 2 , Jane A. Grasby 3 , David P. Hornby 2 , Gary J. Sharples 4 and ... 269) 1533 and Holliday junction bound by Ec RuvA (Table 1), illustrating the additional stability of the Holliday junc- tion -RuvA complex. The bindin...

Ngày tải lên: 17/03/2014, 17:20

... Ó FEBS 2002 S -Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) Robbert H. ... m M of S-decyl-glutathione, the meas- ured ATPase activity represented approximately the basal ATPase activity. This type of behaviour was also obs...

Ngày tải lên: 17/03/2014, 23:20

... study may not include all of the works dedicated to the topic. Other key works may be available and may provide fur- ther understanding of the topic. Clearly, more joint efforts of this kind ... controlled trials of psychotherapy and concluded that reality-orientated psychotherapy is superior to a dynamic, insight-orien- tated approach. Nevertheless, exploratory psychotherapy may ha...

Ngày tải lên: 08/08/2014, 21:20

... capacity to drive the key pathways typically associated with the pathogen- esis of OA. As shown here, as well as by others, IL-1 abruptly shifts the metabolism of the chondrocyte stimulating the expression ... Given the breadth of chondroprotection provided by glucosamine as shown here, it is likely that these signaling pathways also are functionally blocked by glucosamin...

Ngày tải lên: 09/08/2014, 08:23

... properly cited. Abstract The aim of the present study was to evaluate the relative contribution of human leukocyte antigen (HLA)-C locus alleles in determining the risk and the clinical expression of ... additional arthritogenic risk. HLA-C alleles may modulate some aspects of the clinical expression of PsA, but these findings need confirmation. Introdu...

Ngày tải lên: 09/08/2014, 08:23

... 1 Research article Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection Tao Tang 1 , ... not induce the repair of osteochondral defect. Interestingly, remarkably strong staining for hyaluronan was demonstrated in areas that were...

Ngày tải lên: 09/08/2014, 10:22

... article Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular ... produce and by their biochemistry [12]. Previous work [35] on type II A pro -collagen in the developing human disc found that d...

Ngày tải lên: 09/08/2014, 10:23

... knowledge, the first study on the possible implication of the ephrin system during the course of OA. The present study investigating the effect of ephrin B2 in the pathogenesis of human OA chondrocytes ... pro-inflammatory cytokines, some of which are the same, investigating on human OA chondrocytes the effect of ephrin B2 on these factors is also...

Ngày tải lên: 09/08/2014, 14:22

... respectively, starting from the 5’-end of the precursor (Figure 1a). The identified miRNA-like RNAs are generated by the miRNA biogenesis pathway The newly identified miRNA-like RNAs and the known miRNAs ... not siRNAs. Third, we examined the effect of HEN1 on these miRNA-like RNAs. In plants, small RNAs, including miRNAs, siRNAs and lsiRNAs, are methylated at their 3’...

Ngày tải lên: 09/08/2014, 20:22

... 5 of 9 RESEARC H Open Access Conserved charged amino acid residues in the extracellular region of sodium /iodide symporter are critical for iodide transport activity Chia-Cheng Li 1† , Tin-Yun ... extracellular region of NIS has been demonstrated to be critical for iodide transport in our previous study. The conserved charged amino...

Ngày tải lên: 10/08/2014, 05:21

... al.: Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing. Retrovirology 2010 7:24. Submit your ... Retrovirology 2010, 7:24 http://www.retrovirology.com/content/7/1/24 Page 6 of 8 RESEA R C H Open Access Cysteine 95 and other residues influence the...

Ngày tải lên: 12/08/2014, 23:23

... on the glycaemic response to small intestinal nutrient infusion in critically ill patients with pre-existing type-2 diabetes. Methods: Eleven critically ill mechanically-ventilated patients with ... Access Exogenous glucagon-like peptide-1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients...

Ngày tải lên: 14/08/2014, 07:21