Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt
... Arthritis Rheum 2002, 46:507-513. 30. Proulx S, Kwok E, Shealy DJ, Ritchlin CT, Schwarz EM: Under- standing bone marrow edema in arthritis: 3D -MRI and histol- ogy analyses of TNF-Tg mice. Arthritis ... the road to unraveling the mystery of what MRI bone oedema actually means in RA. The implications are exciting and suggest a new focus for understanding disease patholo...
Ngày tải lên: 09/08/2014, 08:23
... osteoclastogenesis and active bone resorption. Fourth, from a therapeutic standpoint the reversibility of the pathophysiology of destructive arthritis is a key point of inter- est. Since in this model TNF is ... bone turnover, as typically seen in juxta-articular and periarticular damage of inflamed joints in RA. TNF is a proinflammatory cytokine of major impor- tance i...
Ngày tải lên: 09/08/2014, 07:20
... ultrasonographic assessment of synovitis and joint vascularity with radiographic evaluation in a randomized, pla cebo- controll ed study of infliximab therapy in early rheumatoid arthritis. A rthritis Rheum 2004, 50:1107-1116. 10. ... Putte van de LB: Validity of single variables and composite indices for measuring disease activity in rheumatoid arthritis. Ann Rheum Dis 1992,...
Ngày tải lên: 12/08/2014, 11:23
Báo cáo y học: "Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor" docx
... 1 IL-15 is present in synovial tissue in rheumatoid arthritis before and after treatment with infliximabIL-15 is present in synovial tissue in rheumatoid arthritis before and after treatment with infliximab. ... IL- 15 in the synovium of patients with rheumatoid arthritis com- pared with patients with Yersinia-induced arthritis and osteoarthritis. J Pathol 19...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register" ppt
... are RF-negative. Cardiovascular mortality and comorbidity There is increasing interest in the literature regarding the link between inflammatory musculoskeletal conditions and accelerated atherosclerosis. This link is evident ... cumulative disease activity and disease severity. Those patients whose disease starts badly tend to continue to do badly. We have shown the benefits of s...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx
... that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by several growth-inhibited conditions, including irradiation, serum depletion and high cellular density. Surprisingly, they showed ... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx
... may be useful for inhibiting bone destruction in a variety of pathological bone diseases. Inhibitory cytokines produced by T cells on osteoclast differentiation We previously reported that bone- marrow-derived ... online http:/ /arthritis- research.com/content/4/5/281 Find what you’re looking for by using our website’s ‘search’ or ‘detailed search’ functions. Limit it to Arthritis...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot
... assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovial tissues were finely minced and ... bioactivity and clinical response. Using the ability of TNF-α to stimulate rheumatoid arthritis synoviocytes, TNF-α (5 ng/ml) was combined with 20 µl plasma per well in order to incr...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx
... pathology may be distinct in cartilage and bone as opposed to synovial tissue or draining lymph node. For many given cytokines, establishing tissue expression and local function is now relatively straightforward. ... regulatory pathways described for IL-18. High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinic...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... role in autoimmunity and more specifically in rheumatoid arthritis (RA) has been highlighted by a string of reports, one of which is in the last issue of Arthritis Research & Therapy. There ... LS: CD4 + CD25 + regulatory T cells in rheumatoid arthritis: differ- ences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthriti...
Ngày tải lên: 09/08/2014, 06:23