Báo cáo y học: "Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics" pdf

... 3 Collagen type IV staining in healthy and arthritic synovial tissueCollagen type IV staining in healthy and arthritic synovial tissue. Colla- gen type IV was found in the lining layer of synovial ... E-cadherin in syn- ovial tissue [29], our study is in line with a study by Trollmo and colleagues [30], describing E-cadherin expression in the lining layer of...

Ngày tải lên: 09/08/2014, 08:23

... Introduction Rheumatoid arthritis (RA) is a chronic condition, which leads to varying degrees of functional impairment and disability. In early stages, symptoms reflecting the inflammatory ... destructive mechanisms in arthritis. Semin Arthritis Rheum 2001, 30:7-16. 3. Feldmann M, Maini RN: Discovery of TNF-alpha as a therapeu- tic target in rheumatoid arthritis: precl...

Ngày tải lên: 09/08/2014, 01:21

... and disease pro- gression was monitored in one joint per paw using a pre- defined arthritis index on a scale of 0 (normal) to 4 (ankylosis), resulting in a maximum arthritis index of 16. The incidence ... treatment of inflammatory disorders where mac- rophages are key producers of proinflammatory cytokines. DPPC: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DXM-P: dexamethas...

Ngày tải lên: 12/08/2014, 11:22

... proinflammatory and anti-inflammatory effects in animal models of inflammatory diseases. An analysis of cytokine and neuropeptide content of synovial fluid from patients with rheumatoid arthritis has revealed ... an anti-inflam- matory role for VIP [8]. The mechanism of action of these neuropeptides in modulating inflammatory diseases is, at least in part, due to th...

Ngày tải lên: 09/08/2014, 06:23

... atherosclerosis [6]. There is, however, good evidence to suggest that the measurement of endothelial function is highly dependent upon current levels of inflammation. In healthy people, the inflammatory ... response elicited by vaccination is sufficient to temporarily (and reversibly) impair endothelial function [7]. Reduction of inflammation using anti-TNF therapy in RA...

Ngày tải lên: 09/08/2014, 10:22

... fragments of a mono- clonal antibody directed against a specific target fused to a cytokine, thus retaining the functions of both the antibody and the cytokine. In cancer, the use of single-chain antibody fragments ... efficacy and a safety profile that provides the basis for the first clinical trial of antibody- based pharmacodelivery of DEKAVIL in rheumatoid arthritis (R...

Ngày tải lên: 09/08/2014, 14:22

... near infrared imaging of injected indocyanine green (NIR-ICG). The B -in population in PLN and ILN was assessed by immunohistochemistry (IHC) and flow cytometry. Linear regression analyses of ipsilateral ... of rheumatoid arthritis disease activity measures and juvenile arthritis disease activity scores in polyarticular-course juvenile idiopathic arthritis: Analysis of th...

Ngày tải lên: 12/08/2014, 17:22

... by the compensatory anti-inflammatory response syndrome, which is defined by low human leukocyte antigen (HLA)-DR expression on monocytes, increased concentration of the anti-inflammatory cytokine ... monocytes, and the serum concentrations of IL-6 (a proinflammatory cytokine) and IL-10 in patients with AP to determine whether these markers can identify patients at high risk of...

Ngày tải lên: 13/08/2014, 16:20

... study contributes to the understand ing of the specific role of such pain symptoms in worsening the functioning in patients with GAD. The presence of PPS is associated with a statistically and ... related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a cross-sect...

Ngày tải lên: 11/08/2014, 15:22

... circulating IFN inducers [2,3]. Type I IFN activity in SLE is associated with disease severity [1]. TNF was the first cytokine convincingly demonstrated to contribute to chronic inflammation in several ... RA. Introduction Cytokines are key regulators of pathogenic processes in a variety of inflammatory and autoimmune diseases. Major roles for both tumor necrosis factor (T...

Ngày tải lên: 12/08/2014, 11:22