... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations ... skin tumors at an ex- tremely high frequency (1000 fold increased incidence as compared to normal individuals) because of their inability to repair UV-induced DNA lesions....
Ngày tải lên: 31/10/2012, 14:59
... cell-cycle by phos- phorylating the retinoblastoma (RB) protein. Activa- tion of cyclin–CDK complexes is counterbalanced by CDK inhibitors, including those of the kinase inhibitor proteins (KIP) ... survival and, consequently, undergo apopto- sis following inhibition of EGFR tyrosine kinase by gefitinib. Gefitinib has been shown to inhibit cell growth and survival signaling pathways, such...
Ngày tải lên: 16/02/2014, 09:20
Báo cáo Y học: Monoterpene biosynthesis in lemon (Citrus limon) cDNA isolation and functional analysis of four monoterpene synthases pot
... are proteolytically processed into their mature forms. Plastid targeting signals are typically rich in serines and threonines and low in acidic and basic amino acids and about 45–70 amino acids ... from GC1 to GC2 from 6.6 min to 7.1 min (a-pinene) and 10.2 min to 10.4 min (b-pinene). The fused silica capillary column in GC2 (30% 2,3-diethyl-6-tert- butyl-dimethyl-b-cycl...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo khoa học: Nucleosome positioning in relation to nucleosome spacing and DNA sequence-specific binding of a protein doc
... Rice University, Houston, TX, USA) according to the method described therein. The activity of the protein was estimated by a gel shift assay, and saturating amounts of protein (typically, 12.2 pmol ... linker histones, protein phosphorylation, and the presence of core histone tails [18,24]. Spacing of nucle- osomes is also in uenced by DNA topology or histone variants [19,25]. Using th...
Ngày tải lên: 16/03/2014, 10:20
Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... I and DNA gyrase content of the cells was estimated by quantitative W estern blotting using a n antibody against topoisomerase I and GyrA subunit, respectively. P uri®ed topoisomerase I and gyrase ... EcoRV and SspI and a 572-bp fragment containing the N-terminal part of the topA gene was isolated and inserted into pUC19 digested with SmaI, re sulting in th e plasmid pHA5. PTOPA...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo hóa học: " Muscle fatigue in relation to forearm pain and tenderness among professional computer users" docx
... on a nominal scale with eight pain categories (no pain, very little pain, little pain, little to moderate pain, moderate pain, moderate to severe pain, severe pain, and very severe pain). Subjects ... reporting at least moderate pain in one or both forearms during the past 7 days were defined as symptom cases in the NUDATA study and were offered a clinical examination that took pl...
Ngày tải lên: 20/06/2014, 00:20
báo cáo hóa học: " Nerve conduction in relation to vibration exposure - a non-positive cohort study" pdf
... managers, engineers, secretaries, and economic clerks, were randomly invited into the study. At the baseline examination in February 1987, 93 of 112 manual workers, including we lders, grinders, turners, ... numbness, pain in wrist or fingers, and difficulty in buttoning clothing, reported either in the questionnaire or during medical examination. There were 4 subjects with bilat-...
Ngày tải lên: 20/06/2014, 00:20
Báo cáo y học: "Personality styles in patients with fibromyalgia, major depression and healthy controls" potx
... phenom- enology and family history study. Am J Psychiatry 1985, 142:441-446. 14. Kirmayer LJ, Robbins JM, Kapusta MA: Somatisation and depres- sion in fibromyalgia syndrome. Am J Psychiatry 1988, 145:950-954. 15. ... personality traits called sociotropy and autonomy. Sociotropy refers to dependent traits, characterized by an intense need for love, approval and being esteemed by ot...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: " Regional coordination in medical emergencies and major incidents; plan, execute and teach"
... within the command and con- trol centre (Figure 1 and 2). A system with a duty officer (RTiB) (RN, specialized in emergency care combined with further training in disaster medicine as well as in ... to be included in the risk assessment regarding possible major incidents in this region. The purpose of this study was to find whether this institution has achieved its primary t...
Ngày tải lên: 25/10/2012, 09:56
Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"
... laboratory investiga- tions. For example, in our study the mean number of laboratory tests performed on patients in the ICU ranged from 61 to 74 individual laboratory tests per patient per day and ... S: Hypernatremic dehydration in nursing home patients: an indicator of neglect. J Am Geriatr Soc 1983, 31:466-471. 2. Mahowald JM, Himmelstein DU: Hypernatremia in the elderly: rela...
Ngày tải lên: 25/10/2012, 10:31