Báo cáo y học: "Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma" doc

... examples of latent growth factors have already been reported. Insulin-like growth factors are inactive when bound to insulin-like growth factor- binding proteins. Transforming growth factor- b ... tissue injury In order to elucidate the in vivo roles of proteolytic processing of HGF, we examined the molecular forms of HGF by immunoblotting using a heavy chain- specifi...

Ngày tải lên: 15/03/2014, 11:20

... more rapidly resynthesized, so that the intact form of the Kunitz domain inhibitor predominates in the crystal structure [35]. According to this model, the intact KD1 peptide bond in the KD1–HGFA ... reflects the capture of the dominant form, owing to the more favorable rate of peptide bond resynthesis during crystallization. Enzymatic kinetic experiments showed that...

Ngày tải lên: 15/03/2014, 11:20

... generation from protein C by inhibition of the thrombomodulin (TM)–thrombin com- plex, and inhibits APC in the presence of heparin-like proteoglycan in the protein C pathway. PKC, protein kinase C. HGFA: ... replaced by Ala) and that by wild-type PCI in the presence or absence of heparin. The data showed that the inhibitory activity of R362A-PCI against HGFA in th...

Ngày tải lên: 22/03/2014, 21:21

... was initially confirmed in a rat model of liver injury induced by carbon tetrachloride [24,31]. In that study, the genera- tion of active HGF ⁄ SF in the injured liver tissue was significantly suppressed ... kDa heavy chain and a 32 kDa light chain [11]. The catalytic domain is present in the 32 kDa light chain. Plasma kallikrein may further cleave the Arg372-Val373 bond...

Ngày tải lên: 22/03/2014, 21:21

... mechanical wound in the dorsal skin of mice and examined the in ltration of macro- phages by measuring the CD68 mRNA level. One day after injury, the levels of CD68 mRNA in the wounds of HGFA )/) mice ... Proteolytic activation of single- chain precursor macrophage-stimulating protein by nerve growth factor- gamma and epidermal growth factor- binding protein, me...

Ngày tải lên: 29/03/2014, 23:20

... Corning, Inc., Corning, NY, USA) assay to evaluate PC9 cell migration and invasion in vitro. In both the migration assay and the invasion assay, an initial equi- librium, obtained by adding 0.6 ... expression in a subset of human lung cancers To gain further insights into the role of miR-125a-5p in lung carcinogenesis and to examine the clinical rele- vance of our finding...

Ngày tải lên: 07/03/2014, 00:20

... and endothelial cells into the damaged site. It has been showed that fibroblasts cultured in presence of increasing doses of HA have an increased production of pro-inflammatory cyto- kines such ... characteristic is largely responsible for the consistency of the active component that can act as a barrier to the spread of any bacteria penetrating the tissues includin...

Ngày tải lên: 03/11/2012, 11:35

... antibody. The involvement of SphK-1 activation in our system is in agreement with the notion that the activation of SphK-1 by external stimuli, includ- ing growth factors, results in accumulation of ... as the G a0 -coupled receptor, may play a role in the prosaposin-triggered signal pathway leading to ERK phosphorylation. Indeed, in other cell systems, activation...

Ngày tải lên: 24/03/2014, 00:21

... essential for PGF 2a -induced activation of the NOX1 promoter. Binding of MEF2 to the consensus sequence in the NOX1 promoter To verify whether the transcription factor MEF2 actu- ally binds to the consensus ... a consensus binding site for myocyte enhancer factor 2 (MEF2), to which binding of MEF2 was augmented by PGF 2a . Gene silencing of MEF2B by RNA interference s...

Ngày tải lên: 30/03/2014, 03:20

... basic cell cycle machinery [3±5]. The investigated cell lines are commonly arrested by IFN in the G1 phase of the cell cycle, an effect that is coinciding with the up-regulation of the cyclin-dependent ... the PtdIns3K pathway has been linked to the activation of the basic cell cycle machinery in primary T-lymphocytes [28]. IL-2 indu ced activation of this pathway...

Ngày tải lên: 31/03/2014, 15:20