Báo cáo y học: "Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid" pdf

... markers of bone metabolism and are regulated in bone by pro-inflammatory cytokines. The objective of this study was to investigate the role of HNE in OA osteoblast metabolism by determining its ... demon- strated by inhibition of ALPase activity. ALPase participates in the differentiation of osteoblasts and provides phosphate for hydroxyapatite mineral formation. Its...

Ngày tải lên: 09/08/2014, 08:22

... hardly inhibited by MU up to 1.0 m M (data not shown). This result suggest that the inhibition of HA production was not caused by direct inhibition of HAS activity. Effect of MU on HAS activity in ... obtained using cultured human skin fibroblasts. It seems likely therefore that the mechanisms of inhibition of HA synthesis by MU are very similar if not identical between...

Ngày tải lên: 08/03/2014, 09:20

... J: Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimu- lating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. ... preventing the development of pathology in the Tg197 transgenic murine model of RA, in which inflammatory polyarthritis is clinically detectable at 4 weeks of age, with swe...

Ngày tải lên: 09/08/2014, 01:23

... articular chondro- cytes and as the main precursor for the synthesis of ECM gly- cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis in OA chondrocytes by HNE (data not shown) ... augmented the cytotoxic effect of HNE as determined by MTT assay. In contrast, the overexpression of this enzyme in chondrocytes offered significant protection against...

Ngày tải lên: 09/08/2014, 13:21

... beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (HDHC2) Recurrence 4 ENSG00000156234 CXCL13- 001 10639 78747983 G A R 56 R H C-X-C motif chemokine ... papillary adenocarcinoma, although the presence in the tongue may indicate an origin in a minor salivary gland. Adeno- carcinomas of the tongue are rare and represent the minority (20 to 25%)...

Ngày tải lên: 09/08/2014, 20:22

... These include fatigue, joint pain, joint tenderness, joint swelling, duration of morning stiffness, joint swelling, and ESR [21]. The EULAR response criteria use an index of disease activity (the ... minutes No fatigue No joint pain by history No joint tenderness or pain on motion No soft-tissue swelling in joints or tender sheats ESR < 30 mm/1st hour in women or < 20 mm/1st...

Ngày tải lên: 09/08/2014, 08:22

... the carboxyl-terminal and amino-terminal regions by a kinase in the MEKK1 pathway, resulting in increased acetylase activity [33]. In the present study, caMEKK1 increased NF-κB, atRA-induced RAR ... transcription factors, including Sox9, NF-κB and RARs, for full activity. In the present study, ectopic expression of p300 increased basal Sox9 activity. Moreover, increasing p300...

Ngày tải lên: 09/08/2014, 10:22

... of HAT activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling, may increase the DNA binding and activity of transcription factors, and may increase ... tools in the treatment of many chronic inflammatory diseases, including asthma and RA. Recent findings in the study of inflammatory lung diseases demonstrate that HAT activi...

Ngày tải lên: 09/08/2014, 11:20

... development of rhythmicity during several years after birth [19,22,23]. The Research Institute of Perinatal Medicine, Obstetrics and Gynecology has been conducting investigations on fetal rhythmicity since ... of definite reduction of functional levels of the fetal physiological systems necessary for vital activity. Background Animal homeostasis is based on rhythmic activity of...

Ngày tải lên: 10/08/2014, 09:20

... arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We studied in a porcine model ... limited number of animals. An ongoing clinical study with LIM in patients undergo- ing cardiopulmonary bypass should confirm clinical effi- cacy and safety. Competing interests S...

Ngày tải lên: 11/08/2014, 08:21