Báo cáo y học: "CD97 neutralisation increases resistance to collagen-induced arthritis in mice" pdf

... this study abrogated binding to chondroitin sulfate B in addition to blocking binding to CD55. Although 1B2 does not block chondroitin sulfate B binding in vitro [17], it could sterically hinder ... haematoxy- lin and eosin or safranin O fast green. Inflammation was graded on a scale from 0 (no inflammation) to 3 (severely inflamed joint) based on infiltration by inflamma- tory ce...

Ngày tải lên: 09/08/2014, 08:22

... recruit- ment of additional inflammatory cells into the sublining region that, in turn, lead to continuous production of inflammatory mediators and enzymes, resulting in destruction of joint struc- tures ... of 0 to 3: 0, no inflammation; 1, slight thickening of synovial cell layer and/or some inflammatory cells in the sublining; 2, thick- ening of synovial lining, infiltration of t...

Ngày tải lên: 09/08/2014, 07:20

... the inhibitory 3DL1 are located in the intracytoplasmic tail. The inhibitory receptor has a long tail containing immunoreceptor tyrosine inhibitory motifs, whereas the activating receptor has a short tail ... HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC class I...

Ngày tải lên: 09/08/2014, 08:22

... HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC class I receptors has ... I molecules may lead to clonal expansion [26]. In a similar way to CD28, KIR receptors may function as T-cell receptor (TCR) co-stimulatory molecules. Interestingly, circulating effector...

Ngày tải lên: 09/08/2014, 08:22

... one year after he finished taking temozolomide. This should provide further insight into a possible toxicity profile of this alkylating agent. This finding should be of interest to physicians in ... T-ALL in a patient receiving treatment [6]. TMZ is an oral alkylating agent that is now known to be active against a var iety of CNS neoplasms. After oral absorption, it spontaneously hydr...

Ngày tải lên: 11/08/2014, 03:21

... T-ALL in a patient receiving treatment [6]. TMZ is an oral alkylating agent that is now known to be active against a var iety of CNS neoplasms. After oral absorption, it spontaneously hydrolyzes to ... Peripheral blood flow cytometry on immunophenotyping with five-color cytomics (fc500 Beckman Coulter flow cytometer) showed this popula- tion of cells with bright reactivity with Pan-T-ma...

Ngày tải lên: 11/08/2014, 07:20

... anti-inflammatory and immunomodulating cytokine, has been shown to prevent some inflammation and injury in animal and clinical studies, but the efficacy of IL-10 treatment remains unsatisfactory. We ... Bennett B, Figdor CG, de Vries JE: Inter- leukin 10(IL-10) inhibits cytokine synthesis by human mono- cytes:an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991, 174:1209-...

Ngày tải lên: 11/08/2014, 08:21

... are several proteins which play a role in drug resistance mechanisms. Such cellular factors are resistance proteins, which can be determined by im- munohistochemistry. Laboratory experiments with ... Cytostatica. Klin Wschr. 1970; 48: 374-376. 29. Reinhold U, Tilgen W. Chemosensitivity Testing in Oncology. Berlin: Springer; 2003. 30. Blumenthal RD. Chemosensitivity Vol 1, In Vit...

Ngày tải lên: 25/10/2012, 11:10

... respectively. Chondrocyte phenotype was investigated using RT-PCR and Western blot analysis. Over 7 days, sphingomyelinase increased the release of newly synthesized sulphated glycosaminoglycan and ... into the media, whereas inhibition of PKR in sphingomyelinase-treated cells reduced the level of newly synthesized sulphated glycosaminoglycan and collagen. Sphingomyelinase treated chondrocy...

Ngày tải lên: 09/08/2014, 08:22

... Recently, it was demonstrated that tea catechins directly bind to DNA and preferentially bind to poly(A), poly(U), and poly(AU) in RNA [42]. It will be interesting to investigate if green tea polyphenols ... secretion of these cytokines in TTP knockout mice results in a severe sys- temic inflammatory response including arthritis, autoim- munity, and myeloid hyperplasia [13,14]....

Ngày tải lên: 11/08/2014, 08:21