Báo cáo y học: "Fine mapping of genes within the IDDM8 region in rheumatoid arthritis" pot

... box- binding protein (TBP) amongst others. The aim of this study was to fine map the IDDM8 region on chromosome 6q27, focusing on the genes in the region, to identify polymorphisms that may contribute ... models of autoimmu- nity [1,2]. Recently convincing proof of this hypothesis has been provided by the association of the missense single nucle- otide polymorphis...

Ngày tải lên: 09/08/2014, 08:22

... only scarcely found in the T-cell infiltrates of the rheumatic synovial membrane and has therefore not been con- sidered a key cytokine in the pathogenesis of RA [26]. Several reports instead indicate ... [1]). In the synovial joint, infiltrating T cells are predominantly of the CD4 + pheno- type and are often found in the proximity of B cells and macro- phages. T...

Ngày tải lên: 09/08/2014, 10:21

... than that in OA, irrespective of the extent of HIF-1α staining. Similarly, the extent of PD-ECGF expression in the syn- ovial rheumatoid stroma was significantly higher than that in the osteoarthritic, ... HIF-α-dependent synovial angiogenesis in OA. By contrast, the activation of the angiogenic VEGF/KDR pathway was persistently increased in RA, as indeed was m...

Ngày tải lên: 09/08/2014, 01:21

... accumulation of these cells in the inflamed synovia and that blocking the effects of TNF decreases trafficking into and retention of B cells in the synovia, thereby increasing their proportion in the ... have overlapping roles in this setting, although LTα may play a predominant role in promoting the formation of tertiary lymphoid tissue at sites of chronic infla...

Ngày tải lên: 09/08/2014, 14:22

... [14]. Nevertheless, serum adiponectin concentrations correlate with the severity of RA evaluated by the extent of joint destruc- tion, indirectly suggesting that adiponectin may be involved in joint ... Adiponectin may play a significant role in the pathogenesis of RA by stimulating the production of VEGF and MMPs in FLSs, leading to joint inflammation and destruction, r...

Ngày tải lên: 09/08/2014, 14:22

... explore the nature of the binding site and the process of catalysis for a-amylases. Although the overall structure and the tertiary folding of the polypeptide chains of different a-amylases have ... subsite at the nonreducing end of the binding site and there are two glycone and five aglycone binding sites. The rice model may be reminiscent of the action of t...

Ngày tải lên: 08/03/2014, 09:20

... the two hypotheses, followed by mul- tiple testing correction by false discovery rate (q < 0.05) using Qvalue [117]. This gives a list of genes where ω in the lineage of interest (zebra finch, ... began by considering the orthologs of genes that have been most strongly implicated in learning and neuronal plasticity in humans, identifying them by searching the OMIM d...

Ngày tải lên: 09/08/2014, 20:22

... binding within coding regions or within an operon presents additional ways of modulating expression of the target genes [43]. Functional validation using reporter assays For several of the ... Young RA: responses modulated by most two component systems in these SRB are unique to the ecological niches they occupy. In addition the significant numbers of hypothet...

Ngày tải lên: 09/08/2014, 23:20

... Cen- tral Microbiology Laboratory of Selcuk University Meram Faculty of Medicine from various clinics were included in the study and kept at -70ºC until per- forming laboratory study. Coombs anti-brucella ... analyzed by using the paired t test method on SPSS for Windows 13.0 software. This study was approved by the local institutional ethics committee of the Selcuk Unive...

Ngày tải lên: 25/10/2012, 10:56

... b b i i o o g g r r a a p p h h y y Mansour Mirsamadi obtained MD degree from University of Tehran in 1978, and then studied ophthalmology for three years in Iran University of Medical Sciences. He is currently an ... associate professor in Department of Ophthalmology, Iran University of Medical Sciences, with research interests in epidemiology in ophthalmology. I...

Ngày tải lên: 03/11/2012, 09:49