Báo cáo y học: "Response to commentary by Dixon and Silman on the systematic review and meta-analysis by Bongartz et al" doc

... malignancy and serious infection? Commentary on the meta-analysis by Bongartz et al. Arthritis Res Ther 2006, 8:111. Letter Response to commentary by Dixon and Silman on the systematic review and meta-analysis ... support from and has been a consultant to Amgen, Centocor. References 1. Dixon W, Silman A: Is there an association between anti-TNF...

Ngày tải lên: 09/08/2014, 08:22

... duration 10 years) and had previously failed to respond to aggressive therapy, as reflected by a failure to respond to a median of four disease-modifying antirheumatic drugs. Infliximab therapy was ... of the DAS28 score by means of a discriminant analysis. The coefficients obtained by discriminant analysis were similar to Letter Response to the commentary ‘Pooled...

Ngày tải lên: 09/08/2014, 08:22

... additional fall in ETCO 2 . We hope the response addresses the concerns of the reader. Thanking you Hemant Bhagat, Anil Agarwal, Manish S Sharma Competing interests The authors declare that they ... Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and ar...

Ngày tải lên: 10/08/2014, 10:20

... due to the formation of 1-alk- 1-enyl-2-lyso-GPE by PLA 2 (d). Enhanced remodeling is accompa- nied by an increase in the formation of 1-alkyl-2-lyso-PAF (e), which is converted, to PAF by acetyl ... a putative specific cytosolic phospholipase A 2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF 3 ), on arachidonic acid (AA) release and lipid mediator biosyn- thesis by...

Ngày tải lên: 22/02/2014, 07:20

... identify and to (semi)quantify work- and environmental exposure in the past, preferably from the conception onwards - up to the day the case su bject is referred for causality determination. Recognition ... scheme/company is likely to ask questions on caus- ality and possibly on weighed attribution in order to get science-based answers that may meet their needs, per-...

Ngày tải lên: 20/06/2014, 00:20

... efficacy [10]. The Euro- pean League Against Rheumatism response criteria based on DAS28 were used to assess the response to therapy [11]. Isolation of mononuclear cells and flow cytometry PB mononuclear ... not for citation purposes) cacy and response to rituximab therapy, consistent with the notion that targeting cells with the memory phenotype is a key determinant for i...

Ngày tải lên: 09/08/2014, 14:22

... KNA also conducted the analysis. MBK, JTB, RSH, RJB, MAH made substantial contributions to the design of the study, interpretation of the data, and revised the manuscript critically for important intellectual ... Broadway, Baltimore, MD, 21205, USA. 21 Department of Medicine, University of Toronto, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada. 22 Department of Medicine, Yale...

Ngày tải lên: 10/08/2014, 05:21

... possibility as the D to N mutation is conserved in four of the six constructs (Fig. 1), which nonetheless retain the contrasting solubility profiles for their respective fusion proteins. Finally, to ... that the fusion proteins were labile and only partially soluble in five of the constructs resulting in very poor yields. Intriguingly, in the sixth con- struct, the yield of...

Ngày tải lên: 23/03/2014, 21:20

... and third, to identify an APL capable of modulating the pro-inflam- matory response to the synovial auto-epitope. Materials and methods Peptides and altered peptide ligands Peptides were synthesised ... TCR agonists on the one hand and prevent unwanted immune reactivity on the other [32,33]. This approach may thus provide an improved option for APL therapy. The objec...

Ngày tải lên: 09/08/2014, 10:20

... the nanotubes and polymer which ultimately controls the interface between the CNTs and the polymer matrix. Unfortunately pure CNTs are insoluble in any organic solvents and they tend to form agglomerates because ... func- tionalized MWCNTs. In the acid functionalized MWCNTs, the peaks at 1634 and 1295 cm -1 correspond to C=O and C–O stretching, respectively. The tw...

Ngày tải lên: 22/06/2014, 01:20