Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc
Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc
... properly cited.Abstract Nitric oxide (NO) may play important roles in rheumatoid arthritis(RA). RA is an inflammatory disease involving joints and othersystems including salivary glands. To ... for individual differences in creatinine clearances. Thefinding of increased NOx and NOx/creatinine ratios in serum(but not in urine) in patients with RA raised the possibility thatcontrols and ... we note in thekidney) by the salivary glands might influence NOx levels in serum and urine. Our studies document low basal salivary flow and tear flow in patients with RA, but salivary NOx levels...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... & Ringe, D. (1994) Role of the divalent metal ion in sugar binding, ring opening, and isomerization byD-xylose isomerase: replacement of a catalyticmetal by an amino acid. Biochemistry 33, ... unchargedpolar amino acids (i.e. Q, N, S, and T) and an increase in charged amino-acid residues (i.e. K, E, and R) in hyperthermophilic proteins. As S and T can catalyze thedeamination and backbone ... contain any Mg2þat pH 6.0, and contain Mg2þonly in site M1 at pH 8.0 [42]. As allFig. 7. Thermal unfolding of apo-BLXI in the presence and absence of metals followed by DSC. See Materials and...
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Báo cáo y học: "Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort" ppt
... diseaseactivity score, the use of this score represents a handicap forthe evaluation of the efficacy of cyclosporin A on disease activ-ity. On the other hand, cyclosporin A inhibits the synthesis of IL-17 ... Spain. Throughout the follow-up of theEMECAR cohort, the percentage of patients without anyDMARD declined while the frequency of patients on combinedtherapy increased. In addition, combination ... analysis and helped to draft themanuscript. IG-A participated in the design of the study and also in collection of the data at the Hospital Universitario de laPrincesa, was involved in the interpretation...
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Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps
... CombinationTherapy Trial Group: Delay to institution of therapy and induc-tion of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. ... 9-month RCT of hydrox-ychloroquine versus placebo in early RA. Three years afterthe study ended, early DMARD therapy still resulted in less pain and disability.The report by Verstappen and colleagues ... monother-apy, and median X-ray damage had increased by 1 Sharpunit with combined therapy and by 4 Sharp units withmonotherapy. Five years later the benefits of combinationtherapy on joint damage...
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Báo cáo y học: "Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis" ppt
... Sugawara K, Ikenaka T: Conver-sion of peanut trypsin-chymotrypsin inhibitor B-III to a chymo-trypsin inhibitor by deimination of the P1 arginine residues in two reactive sites. J Biochem 1987, ... representing candidateautoantigens in RA, including protein and overlapping pep-tides representing native and citrullinated fibrinogen. Synovialmicroarray analysis demonstrated targeting of citrullinatedfibrinogen ... anti-citrullinated fibrinogen autoantibodies and circulating ICs containing fibrinogen.Immunohistochemistry demonstrates co-staining of fibrinogen, complement component C3, and immunoglobulin in pannus...
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Báo cáo y học: "Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case–control study" pot
... group in the case–control study is, in part, probably related to the combined use of both a highly sensitive protein stain and highly sensitiveimmunofixation electrophoresis. Using similar analytical ... and NIH between 1993 and 2000, and subjects from a study of the underlying mechanisms of primary fibromyalgia (fibromyal-gia syndrome (FMS)) from 1986 to 1989 and from the EarlyUndifferentiated ... prevalence of paraproteinemia in our study may alsobe related to the reportedly high prevalence (~3–6%) of para-proteins in subjects with CTD [15] and the relatively high prev-alence of CTD (6%) in...
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Báo cáo y học: "Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats"
... and clinical studies in animal models and human beings are needed to un-derstand molecular elements, ligand and receptors, involved in the mode of action of ozone and HBO. Finally, according ... mechanisms of hyperbaric oxygen in the treatment of ischemia-reperfusion injury. Int Anesthesiol Clin 2000;38:91-109 31. Korkmaz A, Oter S, Deveci S, et al. Involvement of nitric oxide and hyperbaric ... reduced oxidative stress indices and myeloperoxidase activity, levels of serum proinflammatory cytokines and histopathological injury scores considering lung tissue in septic rats. Compared...
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Báo cáo y học: "Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy" ppt
... vimentin is present in synovialmembranes and is released in increased amounts in responseto growth factors and proinflammatory cytokines, suggestinginvolvement in the pathophysiology of RA [24]. The ... for diagnosing RA. APF detection is avail-able only at specialized laboratories, as obtaining and stand-ardizing the substrate is technically challenging, and interpreting the immunofluorescence ... largely subjec-tive [4].Anti-filaggrin antibodies recognize citrulline residues formedby post-transcriptional modification of arginine by peptidy-larginine deiminase [5]. Enzyme immunoassays...
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Báo cáo y học: " MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage" ppt
... Hickling P: Disease activ-ity in longstanding ankylosing spondylitis – a correlation of clinical and magnetic resonance imaging findings. Clin Rheu-matol 2008, 27:449-455.25. Baraliakos X, Landewe ... recruitment and participated in data entry. JL partici-pated in data entry and analysis. FMM conceived of the study and coordinated patient recruitment, data entry, data analysis and preparation of the ... score and PF-SF-36) or indicators of the severity of skin and nail disease(PASI and nail severity score) (Table 2).MRI and XR scores in AM vs non-AM patientsMRI scans of the dominant fingers (including...
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Báo cáo y học: " T cells and post menopausal osteoporosis in murine models" doc
... in elucidating thecrosstalk between the immune system and bone and in uncovering the mechanism by which sex-steroids, infection and inflammation lead to bone loss by disregulating Tlymphocyte ... approximately50% of the increase in the number of T cells in the periphery,while the remaining 50% is due to enhanced peripheralexpansion. Similarly, thymectomy decreases by approximately50% the ... production by increasing thenumber of TNF producing T cells without altering the amount of TNF produced by each T cell [14]. Ovx causes anexpansion of the T cell pool in the BM by increasing T cellactivation,...
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