Báo cáo y học: "Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis" pdf

... Ishibashi T, Nakayama T, Minami A, Yasuda K, Tohyama H: Inhibition of joint inflammation and destruction induced by anti-type II collagen antibody/ lipopolysaccharide (LPS)-induced arthritis in ... re-probed with rabbit anti-β-actin to verify equal loading. Gelatinase assay Gelatinase activity of RA synovial fibroblast culture media was measured using EnzChek gelatinase assay kits (Inv...

Ngày tải lên: 09/08/2014, 08:22

... 72.9% females (282/387) and had a median age of 63.1 years. Patients had a median disease duration of 10 years, and had moderate disease activ- ity (mean DAS28 score 4.2). Disease-modifying anti-rheumatic ... suggests that MTX may protect against its development. This association has also recently been observed in a study by Zonana-Nacach and colleagues [30]. In that study, this...

Ngày tải lên: 09/08/2014, 14:22

... was also raised but to a more modest extent. Thus, there was an Commentary Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious ... randomized clinical trials reported by Bongartz and coworkers raised concerns about an increased rate of malignancy and serious infection in rheumatoid arthritis patients tre...

Ngày tải lên: 09/08/2014, 08:22

... play a critical role in initiating and propagating the disease process. The cytokines tumour necrosis factor α (TNFα) and interleukin-1 (IL-1) mediate many of the inflammatory and tissue-damaging activities ... recovery phase of AA, displaying a TNFα profile opposite to that of the AA-resist- ant Wistar Kyoto (WKY) rats. Intriguingly, the pre-treatment of LEW rats with TNFα inje...

Ngày tải lên: 09/08/2014, 10:23

... preparation was poor. The invagination of diverticu- lum has an advantage over diverticulectomy in that it minimizes bowel leakage [15]. Moreover, invagina- tion of diverticulum can be easily ... formed of the inner circular and outer longitudinal muscle layers. The vasa recta, which supply the mucosa and submucosa of the colon, penetrate the circular muscle. The weakness of...

Ngày tải lên: 25/10/2012, 10:51

... ectopically expressed cdk3 in association with either cyclin E or cyclin A by transient transfection (Fig. 2A) . Kinase assays indicated that pRb- phosphorylating activity was prominently upregulated ... phosphorylated by both cdk3/cyclin A and cdk3/E in vivo (Fig. 5). Analysis of ik3-1 amino-acid sequence indicates that ik3-1 has a putative ZRXL (Z and X are typically basic) moti...

Ngày tải lên: 24/03/2014, 04:21

... Bradley LA, Alarcon GS, Triana-Alexander M, Alexander RW, Martin MY, Alberts KR: Perceived physical and emotional trauma as precipitating events in fibromyalgia. Associations with health care ... Chiu YH, McBeth J, Silman AJ, Ray D, Macfarlane GJ: A popula- tion based study of chronic widespread pain and the hypo- thalamic–pituitary–adrenal (HPA) axis: results from a pilot study [abst...

Ngày tải lên: 09/08/2014, 01:23

... 2003, 18:605-617. 42. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: ... immune system has evolved a variety of mechanisms to achieve and maintain tolerance both centrally and in the periphery. Central tolerance is achieved through negative selection of...

Ngày tải lên: 09/08/2014, 01:24

... were prepared as described above. Cells were washed and incubated in PBS containing 4% heat-inactivated rat serum, and stained with anti-CD134- biotin/streptavidin-allophycocyanin and anti-CD4-FITC. ... 14, and the disease reached maximum severity at days 20 to 22. After this, inflammation of paw joints gradually decreased and resolved macroscopically at days 35 to 40. At several time poi...

Ngày tải lên: 09/08/2014, 06:22

... the score allows unlimited and immediate assessment of disease activity by including only variables that are available by physical examination and patient questioning at the time of interaction ... variables included in the SDAI. A purely clinical score is a valid measure of disease activity and will have its greatest merits in clinical practice rather than research, where APRs...

Ngày tải lên: 09/08/2014, 06:22