Báo cáo y học: "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity" pot

... years. Results Continuation rates of infliximab therapy Of the initial 511 patients enrolled in the study, 507 effectively started infliximab therapy. All patients had long-standing, active, refractory RA, ... 1 of 7 (page number not for citation purposes) Vol 8 No 4 Research article Four-year follow-up of infliximab therapy in rheumatoid arthritis patien...

Ngày tải lên: 09/08/2014, 08:22

... Gay S: Expres- sion of the collagenolytic and Ras-induced cysteine pro- teinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. ... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density;...

Ngày tải lên: 09/08/2014, 06:22

... bioactivity in rheu- matoid arthritis (RA) patients treated with infliximab. Using this bioassay three patterns were observed and linked to the clinical response in the 20 patients with a 1-year ... been observed when trying to explain loss of infliximab response by the induction of anti-mouse antibodies [11]. Once again, only the demonstration of inhibitory activit...

Ngày tải lên: 09/08/2014, 06:22

... Daha MR, Kluin PM, Meinders AE, Tak PP: Increased expression of IL- 15 in the synovium of patients with rheumatoid arthritis com- pared with patients with Yersinia-induced arthritis and osteoarthritis. ... tissue in rheumatoid arthritis before and after treatment with infliximabIL-15 is present in synovial tissue in rheumatoid arthritis before and a...

Ngày tải lên: 09/08/2014, 07:20

... binding protein, both of which are found in early RA and pre -disease sera [29]. Antibody and T-cell reponses to heavy chain binding protein have been identified both in patients with RA and in animal ... producing cells, which are known to be involved in the induction and maintenance of the proinflammatory cytokine cascade. Role played by B cells as antigen-presentin...

Ngày tải lên: 09/08/2014, 10:20

... probably including the synovium [8,11]. Furthermore DC, along with synoviocytes and macrophages, produce innate immune inflammatory mediators, and these mediators drive inflammatory pathology in ... charged imino side-chain groups with an uncharged carbonyl group, increasing the affinity of citrullinated proteins with the shared epitope. Fibrin and vimentin are two citrulli- n...

Ngày tải lên: 09/08/2014, 10:20

... cytokines are produced in the inflamed synovium as a result of the influx of inflammatory cells from the circulation and synovial cell hyperplasia. The upregulation of proinflammatory cytokines ... high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes and synovial microvessels, and in cartilage adja...

Ngày tải lên: 09/08/2014, 10:21

... antigen presentation in monocytes and inhibits the production of pro- inflammatory cytokines, GM-CSF, and Fc-γ receptors by synovial Mφ. Consistently with cytokine and chemokine downregulation, IL-10 clearly suppresses ... rheumatoid arthritis Cytokines with a dual role are indicated in Tables 4 and 5. Interleukin-6 IL-6 is the most strikingly elevated cytokine in RA,...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... HY, Kingsley GH, Scott DL: A systematic comparison of combination DMARD therapy and tumour necrosis inhibitor therapy with methotrexate in patients with early rheumatoid arthritis. Rheumatology (Oxford) ... were allotted randomly to triple therapy DMARD therapy and 128 to infliximab. Twenty-five percent of patients allo- cated sulfasalazine and hydroxychloroqui...

Ngày tải lên: 12/08/2014, 11:23