Báo cáo y học: "Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis" pdf

... stimulates antigen-dependent cellular cytotoxicity by natural killer cells and macrophages. Conversely, FcγRIIb contains an inhibitory motif in the cytoplasmic tail that abrogates cellular activation and down-regulates ... http://arthritis-research.com/content/8/4/R109 Page 1 of 6 (page number not for citation purposes) Vol 8 No 4 Research article Association of FCGR2A and FCGR2A...

Ngày tải lên: 09/08/2014, 08:22

... 3 μg of human HO-1 expression vector or control vector by using Nucleofector (Amaxa Biosystems; Gaithersburg, MD, USA) and human monocyte Nucleofector kit (Amaxa Biosystems) [25,26]. Twenty four ... Purity of the separated neutrophils, which were determined by flow cytomeric scattergram, was typically above 97% [7]. Monocytes were negatively selected by magnetic cell sorting (Miltenyi...

Ngày tải lên: 09/08/2014, 10:22

... Effects of PPARα, γ and δ haplotypes on plasma levels of lipids and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenet. ... characterized by a rise of HDL and lowering of LDL, triglycerides, and insulin [5]. In addition, transgenic expression of an activated PPARδ in mice confe...

Ngày tải lên: 31/10/2012, 17:03

... folding and oligomeric assembly of various glycoproteins [17]. To study the role of CNX and CRT in the folding of newly synthesized TSHR molecules, we performed pulse- chase analyses on TSHR-K562 cells ... member of the Hsp70 family and promotes the folding and assembly of protein by recognizing unfolded polypeptides and inhibiting intra- and intermolecular aggregation...

Ngày tải lên: 31/03/2014, 08:20

... prevalence of T2D have been the target of many studies. Family history, excess of body fat, and physical inactivity have been linked to T2D [4]. Excess of adiposity, specifically in the central ... Therefore, the objective of this study was to analyze the association of general and central adiposity, cardiorespiratory fitness and exercise practice with T2D in e...

Ngày tải lên: 08/08/2014, 16:23

... anxiety symptoms lead to alexithymia. Table 2: Mean (± SD) scores for Beck Depression Inventory (BDI), Spielberger Trait Anxiety Inventory (STAI) and Toronto Alexithymia Scale (TAS-20). Category ... related to higher levels of anxiety [41]. Due to the limitations of our study, we cannot answer the ques- tion of whether alexithymia leads to depressive and anxi- ety symptoms...

Ngày tải lên: 08/08/2014, 23:21

... MMP1 and MMP3 are secreted on stimulation by inflammatory cytokines; they degrade key components of cartilage and bone matrix [6]. MMP1 expression occurs in cells of the invading front of the ... Therapy Vol 6 No 3 Dörr et al. The destruction of cartilage and bone in RA is mediated by proteolytic enzymes secreted by an inflammatory synovial tissue [5]. Because destructive enzyme...

Ngày tải lên: 09/08/2014, 01:23

... from the Toronto population were genotyped. With respect to Toronto PsA patients, 61% were male and their mean age at the start of the study was 39.6 years (standard deviation 11.3 years). The ... onset of the study was 49.7 years. The mean age at onset of psoriasis was 29.3 years (standard deviation 14.2 years) and the mean age at onset of PsA was 38.1 years (standard deviati...

Ngày tải lên: 09/08/2014, 07:20

... its high frequency in healthy controls. However, it may be another important step on the way to a better understanding of RA etiology and pathomechanisms, in particular the role of angiogenesis. Competing ... Verification of newly found associations would be greatly aided by the deposition of genotypes and detailed phenotype data in public databases such as dbGaP [13] for use in...

Ngày tải lên: 09/08/2014, 10:21

... unlikely to account for the discrepancy. A worldwide association study along with functional studies of the susceptibility SNP should be performed to clarify the significance of TXNDC3 as an OA susceptibility ... design and analysis of the study, and MN genotyped the Japanese samples. JD, JQ, NJ, YX, CY and JW evaluated the patients and genotyped Chinese samples, and...

Ngày tải lên: 09/08/2014, 10:23