Báo cáo y học: "Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis" pdf

... stimulatesantigen-dependent cellular cytotoxicity by natural killer cells and macrophages. Conversely, FcγRIIb contains an inhibitorymotif in the cytoplasmic tail that abrogates cellular activation and down-regulates ... http://arthritis-research.com/content/8/4/R109Page 1 of 6(page number not for citation purposes)Vol 8 No 4Research articleAssociation of FCGR2A and FCGR2A- FCGR3A haplotypes with susceptibility to giant cell arteritisAnn ... properly cited.AbstractThe Fc gamma receptors have been shown to play importantroles in the initiation and regulation of many immunological and inflammatory processes and to amplify and refine...

Báo cáo y học: "Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet''''s disease" potx

... 3 μg of human HO-1 expression vector or control vector by usingNucleofector (Amaxa Biosystems; Gaithersburg, MD, USA) and human monocyte Nucleofector kit (Amaxa Biosystems)[25,26]. Twenty four ... Purity of the separated neutrophils,which were determined by flow cytomeric scattergram, wastypically above 97% [7]. Monocytes were negatively selectedby magnetic cell sorting (Miltenyi Biotec; ... HO-1, as a reg-ulatory factor of inflammatory responses in inflammatorydisorders.In the present study, mRNA expression levels of HO-1, TLR2, and TLR4 in circulating leukocytes from BD patients...

Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"

... Effects of PPARα, γ and δ haplotypes on plasma levels of lipids and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenet. ... characterized by a rise of HDL and lowering of LDL, triglycerides, and insulin [5]. In addition, transgenic expression of an activated PPARδ in mice conferred resistance to obesity and hyperlipidaemia ... allele frequency in their study with healthy young men from Sweden [9]. Treatment of obese rhesus monkeys with GW 501516, a selective PPARδ agonist, led to a significant improvement of metabolic...

Báo cáo Y học:Association of the thyrotropin receptor with calnexin, calreticulin and BiP Effects on the maturation of the receptor docx

... folding and oligomeric assembly of various glycoproteins [17]. To study the role of CNX and CRT in the folding of newly synthesized TSHR molecules, we performed pulse-chase analyses on TSHR-K562 cells ... member of the Hsp70 family and promotes the folding and assembly of protein byrecognizing unfolded polypeptides and inhibiting intra- and intermolecular aggregation [17]. To investigate therole of ... rapidlydegraded just after its synthesis. However it does notseem likely that these interactions are absolutely necessaryfor a proportion of the receptor to be able to foldproperly.Effects of...

Báo cáo y học: "Association of Adiposity, Cardiorespiratory Fitness and Exercise Practice with the Prevalence of Type 2 Diabetes in Brazilian Elderly Women" pot

... prevalence of T2D have been the target of many studies. Family history, excess of body fat, and physical inactivity have been linked to T2D [4]. Excess of adiposity, specifically in the central ... Therefore, the objective of this study was to analyze the association of general and central adiposity, cardiorespiratory fitness and exercise practice with T2D in elderly Brazilian women. 2. ... analysis was used to determine the association of general and central adiposity (BMI and WC), cardiorespiratory fitness (CRF), and EPA classification with T2D. T2D was treated as a dichotomous...

Báo cáo y học: "Prevalence of alexithymia and its association with anxiety and depression in a sample of Greek chronic obstructive pulmonary disease (COPD) outpatients" pptx

... anxiety symptoms lead to alexithymia.Table 2: Mean (± SD) scores for Beck Depression Inventory (BDI), Spielberger Trait Anxiety Inventory (STAI) and Toronto Alexithymia Scale (TAS-20).Category ... related to higher levels of anxiety [41]. Due to the limitations of our study, we cannot answer the ques-tion of whether alexithymia leads to depressive and anxi-ety symptoms or depression and ... their symptoms [22]. In alexithymia,by definition, the difficulty in expressing psychologicalsymptoms as such leads to their expression as somatic(often atypical) symptoms [22]. The latter may...

Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis" ppt

... MMP1 and MMP3 are secreted on stimulation by inflammatorycytokines; they degrade key components of cartilage and bone matrix [6]. MMP1 expression occurs in cells of theinvading front of the ... Therapy Vol 6 No 3 Dörr et al.The destruction of cartilage and bone in RA is mediatedby proteolytic enzymes secreted by an inflammatory synovialtissue [5]. Because destructive enzymes of the ... theconcentration of MMP1 and MMP3 and stored at –80°C(see below).GenotypingMMP1 and MMP3 promoter polymorphisms weredetermined by single-strand conformation polymorphismanalysis. Polymerase chain...

Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx

... from theToronto population were genotyped. With respect to TorontoPsA patients, 61% were male and their mean age at the start of the study was 39.6 years (standard deviation 11.3 years).The ... onset of the study was 49.7 years. The mean ageat onset of psoriasis was 29.3 years (standard deviation 14.2years) and the mean age at onset of PsA was 38.1 years(standard deviation 11.0 years). ... citation purposes)Materials and methodsThis study was approved by the local ethics committee of theMemorial University of Newfoundland and University of Toronto. Informed consent was obtained...

Báo cáo y học: "Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis Peter Ahnert and Holger Kirsten" pps

... its high frequency in healthy controls. However, itmay be another important step on the way to a betterunderstanding of RA etiology and pathomechanisms, inparticular the role of angiogenesis.Competing ... Verification of newly found associations would begreatly aided by the deposition of genotypes and detailedphenotype data in public databases such as dbGaP [13] foruse in (disease sub-type-specific) ... meta-analyses.ITGAV is the latest example of a candidate gene that may berelevant to RA. Increased significance in the combinedsamples in the study of Jacq and colleagues, corroborated bydata...

Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx

... unlikely to account for the discrepancy. A worldwide association studyalong with functional studies of the susceptibility SNP shouldbe performed to clarify the significance of TXNDC3 as an OA susceptibility ... design and analysis of the study, and MN genotyped the Japanesesamples. JD, JQ, NJ, YX, CY and JW evaluated the patients and genotyped Chinese samples, and TN helped with themeta-analysis. BL coordinated ... OA and control groups con-formed to Hardy-Weinberg equilibrium.Statistical analysisStandard χ2 analysis -of- contingency tables were used to com-pare genotype and allele distributions of...

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