Báo cáo y học: "Inhibition of anti-tuberculosis T-lymphocyte function with tumour necrosis factor antagonists" pdf
Báo cáo y học: "Inhibition of anti-tuberculosis T-lymphocyte function with tumour necrosis factor antagonists" pdf
... anti- mycobacterial CD4 + T lymphocytes. Administered in vivo, they decrease the frequency of the subpopulation of memory CD4 + T lymphocytes rapidly releasing IFN-γ upon challenge with mycobacterial ... activation of CD4 + T lymphocytes by mycobacterial antigens, presumably reflecting their higher potency in interacting with mTNF expressed by activated CD4 + T lymphocytes. Such...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "Inhibition of human immunodeficiency virus type-1 by cdk inhibitors" pdf
... binding of cdk9/cyclin T1 to TAR RNA [21]. Recently, a growing body of evidence has indicated the role of yet another cyclin/cdk complex, namely cyclin E/cdk2, in Tat activated transcription. Cyclin ... that hyperphosphorylates the carboxyl- terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J Virol 1995, 69:1612-1620. 11. Baskaran R, Dahmus ME,...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey" ppsx
... syndromes may occur in patients under anti-TNF alpha treatment and may be complicated by central Table 3 Signs of systemic lupus erythematosus (SLE) in 12 patients under anti -tumour necrosis factor ... Con- gress of Rheumatology (ACR) criteria of SLE [9]. Muscu- loskeletal symptoms were taken into account only if they reappeared with other lupus symptoms in a patient in whom the...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: " Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes" doc
... MCP-1 are key proinflammatory mediators, produced mainly by FLSs in the synovium, and play crucial roles in the pathophysiology of RA [29]. TNF-α is a potent activator of production of these proin- flammatory ... proinflammatory cytokines, including IL-1, tumour necrosis factor (TNF)-α, and exhibit characteristics of inflammatory cells that are critically involved in various asp...
Ngày tải lên: 09/08/2014, 10:23
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... cell proliferation of human mammary myoepithelial-like cells by hepatocyte growth factor/ scatter factor depends on heparan sulfate proteoglycans and sustained phosphorylation of Ó FEBS 2002 NAMI-A affects c-myc ... the primary hereditary cardiomyopathy of the Syrian hamster. I. Regulation of prodynorphin gene expression by nuclear protein kinase C. J. Biol. Chem. 272, 6685–6692. 22...
Ngày tải lên: 21/02/2014, 01:21
Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... central participants of complex C and all are required in the catalytic steps of splicing [44±47]. Furthermore, interference of erythromycin with the function of the s pliceosomal and nonspliceosomal protein cofactors ... ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by the substitution, as is often the case in r...
Ngày tải lên: 21/02/2014, 15:20
Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... regulation of tumour- associated hyaluronan. CIBA Found. Symp 13, 150–159. 5. Kosaki, R., Watanabe, K. & Yamaguchi, Y. (1999) Over- production of hyaluronan by expression of the hyaluronan synthase ... treatment may cause a decrease in hyaluronan synthase activity by altering the lipid environment of membranes, especially the distribution of different cardiolipin species, surro...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... inhibition of platelet aggregation [6,7] and inhibition of inflammatory cytokine production in macrophages [8]. Curcumin has also been shown to affect the activity of a number of key enzymes such as cyclooxygenase ... the Ca 2þ -ATPase with differing affinities (a high affinity site with a K d of 0.55 mM and lower affinity site with a K d of 10 m M). In addition to enhancement...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot
... in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. ... R.T. (1994) Glycosylphosphatidylinositols synthesized by asexual erythrocytic stages of the malarial parasite, Plasmodium falciparum. Candidates for plasmodial glycosylphosphatidylinosit...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... crucial role for the hydroxyl group of this tyrosine residue in the binding of 2-APB to the enzyme. DISCUSSION 2-APB has been used extensively recently to investigate the effects of InsP 3 -induced ... the surface of the Ca 2+ -ATPase (Site B). As can be seen in Fig. 9, the loss of the hydroxyl group from the Tyr837Phe mutant enzyme resulted in a reduction of inhibition by 2-APB o...
Ngày tải lên: 31/03/2014, 23:20