Báo cáo y học: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis" potx

... profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines inter- leukin-1 beta and tumour necrosis factor. Inflamm Res 2005, 54:10-16. 42. Zhou A, Scoggin S, Gaynor ... blocking agent (infliximab) are lacking in rheumatoid arthritis, we have used gene profiling in peripheral blood mononuclear cells to predict a good versus poor response to i...

Ngày tải lên: 09/08/2014, 08:22

... understanding of autoimmune diseases using molecular profiling. I will focus on the gene expression analysis of T lymphocytes, the key players in several inflammatory diseases, and on the microarray ... factor family to be differentially expressed in type 1 and type 2 cells. TRAF4 was expressed at a higher level in type 1 cells while TRAF5 was preferentially expressed in type 2 c...

Ngày tải lên: 09/08/2014, 01:21

... conceived the study. HZ per- formed FcγR genotyping and coordinated the statistical analy- sis. YM, TY and YK performed GPI ELISA. TH participated in clinical assessment. TS participated in the full ... modulation – by the low affinity genotype of FcγRs – of the bypass between immune complex and FcγR bearing cells. In a GPI immunized mouse model severe arthritis occurred only in DBA/...

Ngày tải lên: 09/08/2014, 07:20

... advan- tages and drawbacks. From tetracycline and doxycycline, to quinacrine, bleomycin, talc, interferon or even silver nitrate [13-16]. Despite the fact that many surgeons seek the best method of ... immediately introduced into the chest tube. Results: A success rate of 27% was observed having the air leak sealed in 4 patients in less than 24 hours. Conclusion: Despite our disappointing...

Ngày tải lên: 10/08/2014, 09:22

... medical history, clinical features, physical examination, laboratory data (including tests for rheumatoid factor and antinuclear antibodies) and radiographs. Peripheral and axial joints were evaluated ... main haplo- types found in normal and spondylitic patients in Spanish and Jewish populations [13]. Indeed, the spondylitic form of PsA was found in association with the HLA-B27/Cw1 h...

Ngày tải lên: 09/08/2014, 08:23

... purposes) Table 1 Rheumatoid arthritis medical records-based index of severity Sub-scale Points 1. Surgery sub-scale: C1–C2 fusion 3 points Any hand joint 1 point Any foot joint 1 point Major joints (hips, ... point Pulmonary nodule 1 point Maximum score for category: 1 point 4. Clinical status sub-scale: Arthritis flares 1 1 point 2 to 4 2 points 5 + 3 points Worst physician global rating:...

Ngày tải lên: 09/08/2014, 10:23

... donor lymphocytes, only very few cells were found in joints during the first week of transfer, and a second cell transfer was needed to induce a significant influx of lymphocytes into the joints ... adaptive immunity cells (represented by donor BALB/c lymphocytes) and cells of innate immunity (represented by non-lymphoid cells in the recipi- Figure 5 Hierarchical clustering (left)...

Ngày tải lên: 09/08/2014, 06:22

... overexpressed at baseline in poor responders are induced by several cytokines in FLSs, thereby suggesting a role for these cytokines in the resistance to TNF blockade in RA. ANOVA: analysis of variance; ... thereby preventing disease progression in these patients and saving unnecessary costs. TNF antagonists interfere with many pathways involved in RA synovial inflammatory process...

Ngày tải lên: 09/08/2014, 14:20

... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... containing a T7 RNA polymerase promoter. Then cRNA was synthesized using T7 RNA poly- merase which simultaneously incorporates cyanine 3- or cyanine 5- labeled CTP (Perkin Elmer, W...

Ngày tải lên: 03/11/2012, 11:35

... Molecular Cloning. A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory press, Cold Spring Harbor, NY. 25. Hogan, B., Beddington, R., Costantini, F. & Lacy, E. (1994) Tail bleeding. In Manipulating ... xenoestrogens in the ovaries of ArKO mice in vivo. Estrogen plays an important role not only in the reproductive system but also in the regulation of bone metabolism to mai...

Ngày tải lên: 24/03/2014, 03:21