Báo cáo y học: "Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data" ppsx

... or more animal Review Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data Christina D Chambers 1,2 , ... discordance between the FDA Pregnancy Category and currently available data. Secondly, we compare the strengths and weaknesses of post-market...

Ngày tải lên: 09/08/2014, 08:22

... fatty acids. (C) Analysis of all PC species. X :Y values on the x-axis denote the total number of C- atoms of both fatty acids (X) and the total number of dou- ble bonds (Y) , respectively. 0 5 10 15 20 25 30 3 0 : 0 3 2 : 2 3 2 : 1 3 2 : 0 3 4 : 3 3 4 : 2 3 4 : 1 3 4 : 0 3 6 : 5 3 6 : 4 3 6 : 3 3 6 : 2 3 6 : 1 3 6 : 0 3 8 : 7 3 8 : 6 3 8 : 5 3 8 : 4 3 8 : 3 3 8 : 2 3 8 : 1 3 8 :...

Ngày tải lên: 13/08/2014, 05:22

... in which body weight and body fat composi- tion of generally healthy, overweight human volun- teers were examined before and after a 30-day oral treatment with placebo or a test formula containing ... representative of the sponsor and of the Principal Investigator, and the representative formulas of the samples were identi- fied. Table 2 A general summary of the meal pla...

Ngày tải lên: 31/10/2012, 15:12

... Introduction Rheumatoid arthritis (RA) is a chronic condition, which leads to varying degrees of functional impairment and disability. In early stages, symptoms reflecting the inflammatory process often ... and the intra-assay and inter-assay coefficient of variation is <5%. The assay is not influenced by rheuma- toid factors. The serum concentrations of COMP obtained by th...

Ngày tải lên: 09/08/2014, 01:21

... joints of the HgCl 2 -exposed rats demonstrated more marked synovial hypertrophy and hyperplasia and a marked infiltration of the synovial tissues, primarily by neutrophils. This is accompanied by ... resistance to ReA can be overcome by heavy metal exposure. Mercury exposure alters the cytokine profile, host clearance capability, and histopathological out- come from the resistant...

Ngày tải lên: 09/08/2014, 01:22

... production of inflammatory cytokines The signal transduction pathways activated by TLRs culmi- nate in activation of transcription of defensive genes. The expression of many inflammatory cytokines, ... previously described in this model [22] (i.e. the infiltration of inflammatory cells into the syn- ovium, synovial hyperplasia, and fibrinous deposits; Fig. 5a). Infiltration of...

Ngày tải lên: 09/08/2014, 01:23

... damage and chondro- cyte death during ICA and arthritis induced by collagen type II [10,11]. IL-4 is regarded as a potent anti-inflamma- tory cytokine by direct inhibition of proinflammatory cytokines ... pas- sively induced by injecting 3 µg lysozyme coupled to poly- L-lysine in 6 µl pyrogen-free saline into the knee joints. Histology of arthritic knee joints Total knee joints were...

Ngày tải lên: 09/08/2014, 06:22

... clinically indicated. Instead, the clinical relevance of the finding is likely to come through better understanding of the RA pathophysiology and may lead to new therapeutic targets. Contrary to the ... number of heterozygote parents. Table 3 Genotype relative risk analysis for single nucleotide polymorphism (SNP)1 and SNP2 in sample 1 of rheumatoid arthritis trio famil...

Ngày tải lên: 09/08/2014, 10:20

... disease and to choose the appropriate therapy early. The autoimmune response appears early, often prior to the apparition of clinical symptoms, and leads to the production of various autoantibod- ies ... two categories of antigens, enzymes of the glycolytic family and molecular chaperones are also targeted by the early untreated RA autoAb response. For some of these,...

Ngày tải lên: 09/08/2014, 13:22

... recombinant cytokines is often limited by severe toxicities due to the high dosages needed as cytokines often have poor pharmacokinetics and dynamics. A straightforward strategy is the fusion of cytokines ... accumulation of this fusion protein at the site of inflammation, good therapeutic efficacy and a safety profile that provides the basis for the first clinical trial of...

Ngày tải lên: 09/08/2014, 14:22