Báo cáo y học: "β Scar wars: is TGFβ the phantom menace in scleroderma" doc

... significant morbidity. There is no therapy for the fibrosis observed in SSc; indeed, the underlying cause of the scarring observed in this disease is unknown. Transforming growth factor-β (TGFβ) has long been hypothesized ... other cytokines. As mentioned above, in addition to signaling pathways directly induced by TGFβ ligand, there is substantial evidence for synergy bet...

Ngày tải lên: 09/08/2014, 08:22

... agenesis, Dental volumetric computed tomography, Paranasal Sinuses Introduction The frontal sinus is contained within the frontal bone and is situated behind the supercilliary arch [1,2]. The ... Occasionally, one or both sinuses may be absent. The prominence of supercilliary arcs does not indicate the absence, presence or size of the frontal sinus [3]. The object...

Ngày tải lên: 25/10/2012, 11:04

... presence of the endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the ... observed, again in vitro [9]. The endocannabinoid system, comprising membrane receptors for THC, endogenous ligands for these receptors, and proteins for their biosynthesis and ina...

Ngày tải lên: 22/02/2014, 07:20

... and the minimal repair systems [11] in the mitochondria (as compared to the nucleus) increase the likelihood of oxidative damage occurring and being maintained in the mitochondrial genome. The ... increased synthesis of mitochondria would subsequently result in an increase in the production of the nuclear subunits of the ETS system (i.e. the COX – /SDH ++ phenotype...

Ngày tải lên: 17/03/2014, 23:20

... system The type I IFN system comprises the inducers of type I IFN synthesis, the type I IFN genes and proteins, the cells pro- ducing type I IFNs, and the target cells affected by the IFNs. The ... etiopathogenic role in SLE. This hypothesis also indicates new therapeutic targets in this autoimmune disease. Keywords: dendritic cells; interferon-α; lupus; systemic lupus eryth...

Ngày tải lên: 09/08/2014, 01:21

... surgery. Thus, understanding the changes in the CMAP during this type of injury will be useful in the detection and prevention using intra-operative neurophysiologic monitoring. The model involved ... a 3 minute recovery period (3 rd recovery). CMAP's were recorded continuously during the entire period Statistical analysis The term latency always refers to the time del...

Ngày tải lên: 10/08/2014, 10:20

... diagnosis and disease activity Prior to data collection, the diagnosis of RA was con- firmed by the supervising rheumatology consultant using the ACR criteria. Following acceptance into the study ... This high- lights the variability of learning requirements for the technique [26]. The use of MSUS by the podiatrist within this study did reveal good sensitivity and specificity...

Ngày tải lên: 10/08/2014, 21:23

... 3 in the 9th exon of the A alle le, which is deleted in the F allele, is mutatedtoTintheMallele, giving rise to a Ser fi Leu substitution. Analysis of the intronic flanking sequences The flanking ... expected from the phen otypic analysis (at the p rotein level), the f ew animals yielding in their milk the a s1 -CasM variant were exclusively heterozygous M/F a t the...

Ngày tải lên: 22/02/2014, 04:20

... Kubota, H., Hynes, G. & Willison, K. (1995) The chaperonin containing T-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. ... HSP60 in the immunoblotting analysis. However, the antibody cross- reacted mainly with HSP60 in the cytoplasm and with some HSP60 in the mitochondria during electron micr...

Ngày tải lên: 08/03/2014, 09:20

... greater recovery of the phosphorylation of histone H1 mediated by Cdc2 kinase in an in vitro kinase assay. These data indicate that the catalytic domain of p25 rum1 is located in its C-terminal portion ... regulating CDK activity [17–19,21]. By inhibiting G 1 –S kinase activity, p25 rum1 determines the cell-cycle timing of the G 1 –S transition (Start), maintaining cells in...

Ngày tải lên: 17/03/2014, 23:20