Báo cáo y học: "Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium" ppt

... synergy between these two classes of ncRNAs as we have hypothesized here is an intriguing possibility that would significantly increase the regula- tory power of these families of ncRNAs within the ... con- text of a larger ncRNA sensory and regulatory network [44]. These mechanisms, together with the unusual but specific response of the BACE1 system to stress, may explain...

Ngày tải lên: 09/08/2014, 20:22

... compared to the cells transduced with control vec- tor (Fig 2B and 2D) indicating the efficacy of the CXCR4 siRNA on its target. Similarly, to determine the activity of the anti-CCR5 siRNA in the ... transcripts To confirm that the down regulation of both CXCR4 and CCR5 coreceptors as seen by FACS analysis is due to reduced levels of the corresponding mRNAs,...

Ngày tải lên: 10/08/2014, 05:20

... and used in the assays of the antiradical and anti-lipoxygenase activity as standards. LOXs are the family of the key enzyme in the biosynthesis of leukotrienes that are postulated to play an important role ... representing the key enzymes in the biosynthesis of leukotrienes that have been postulated to play an important role in the patho- physiology of several i...

Ngày tải lên: 11/08/2014, 08:21

... com- ponents of NF-κB (data not shown). One of the consequences of inhibition of NF-κB is the inhibition of the nuclear translocation of p50 and p65 through the blockage of IκB release. To study the result ... result of JNK inhibitor suppressed the inhibitory effect of melittin and bee venom on the NF-κB DNA binding activity induced by LPS or SNPFigure...

Ngày tải lên: 11/08/2014, 08:22

... 0.05. (b) Inhibition of leukocyte adherence to the postcapillary endothelium by ALP in vivo. The results show the number of leukocytes adherent to the endothelium of postcapillary syn- ovial ... Germany). The phase contain- Figure 1 Inhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction...

Ngày tải lên: 09/08/2014, 08:22

... vitro. In these authors’ opinions, such studies obviously represent the next logical step in the unfolding story of the modulation of the oligomeric structures of HIV-1 viral enzymes by synthetic peptides ... inhibitory properties ( 50–200 fold) through modification of their amino-acid composition and the addition of a hydrophobic moiety, such aminocaproyl or palmitoyl,...

Ngày tải lên: 08/03/2014, 09:20

... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bond. FEBS Lett. 361, ... the catalytic domain of the enzyme (amino acids 442–731 of human PEP). This fragment was cloned into pPCR-Script Cam (Stratagene). The EcoRI restriction sites of the sub...

Ngày tải lên: 31/03/2014, 08:20

... help bolster the validity of the conclusions presented here. It is important to note that the success of the injections may largely depend upon the skill and expe- rience of the operator [11]. It ... lidocaine in the left thigh, and then re-evaluated for PPT within 1 minute of the injection. The purpose of the control group was to assess the effect of s...

Ngày tải lên: 10/08/2014, 10:20

... a pictorial summary of these findings. However, these conclusions have been drawn on the basis of use of well characterised inhibitors, rather then actual measurement of the activity of the target ... restricted to the cytoplasm by a set of inhibitory proteins and, upon stim- ulation, translocated to the nucleus. This stimulation can be modulated by phosphorylati...

Ngày tải lên: 11/08/2014, 08:21

... "home" to lymphoid tissue at distant sites in gastrointestinal, respiratory, genitourinary and other mucosa-associated regions [17]. In this context, the objective of this study was to analyse humoral ... participated in the study design and participated in the drafting of the manu- script. LRCB conceived the study, data analysis, coordina- tion, the draft and fi...

Ngày tải lên: 11/08/2014, 10:23