Báo cáo y học: "New therapies in fibromyalgia" pps

... mechanisms through the descending inhibitory pain pathways in the brain and spinal cord [8-10]. Dysfunction in serotonin and nor- epinephrine in these pain inhibitory pathways may contribute to the central ... treatments beginning once weekly, followed by twice weekly, and finally three times weekly. Clinically meaningful treatment response, defined by a 30% improvement in pain, occur...

Ngày tải lên: 09/08/2014, 08:22

... models in inhibiting airway eosinophilia and airway hyperresponsiveness. 37 Recombinant IL-12 was administered subcu- taneously in increasing doses (0.1, 0.25, and 0.5 ␮g/kg) weekly in 19 individuals ... widely prescribed. Modifications to sympathomimetics resulted in increasingly long-acting increasingly selective ␤ 2 agonists, the most widely prescribed of which was salbutamol, intr...

Ngày tải lên: 08/08/2014, 20:23

... Carney RM, et al. Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun 2003;17:276–85. 125. Yao JK, Reddy RD. Metabolic investigation in psychiatric disorders. ... F 2 have a variety of effects on airway physiology, including polarizing immune cells to a Th2 phenotype, attracting immune cells, stimulating proinflammatory cytokines, in...

Ngày tải lên: 08/08/2014, 21:20

... [53,55] in myeloid cells suggests that BAFF may act as a kind of secondary cytokine translating mainly IFN and TNF effects. An important immunoregulatory cytokine produced by B cells is ... Boyle DL, Kalled SL, Carson DA, Kipps TJ: Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. ......

Ngày tải lên: 09/08/2014, 14:22

... phenom- enology and family history study. Am J Psychiatry 1985, 142:441-446. 14. Kirmayer LJ, Robbins JM, Kapusta MA: Somatisation and depres- sion in fibromyalgia syndrome. Am J Psychiatry 1988, 145:950-954. 15. ... HC were included if they reported no history of psychiatric disorder, reported no distribution of pain intensity and scored nine or lower on the Beck Depression Inventory [24]...

Ngày tải lên: 08/08/2014, 21:20

... confirm this finding. The missing fast component of reactive hyperaemia in our FM population is presumably due to a higher sympathetic tonus, resulting in increased vasoconstriction; this increased ... far they have been predominantly found in healthy subjects [13]. They also show the same characteristics in therapy and there is so far no proof that one type predisposes to a certain i...

Ngày tải lên: 09/08/2014, 06:22

... 58:371-383. 23. Kochi Y, Yamada R, Kobayashi K, Takahashi A, Suzuki A, Sekine A, Mabuchi A, Akiyama F, Tsunoda T, Nakamura Y, Yamamoto K: Analysis of single-nucleotide polymorphisms in Japanese rheumatoid ... estimations than in European ones. Molokhia and McKeigue previously pointed out the difficulty brought up by admixture in investigating the etiology of rheumatic diseases, notabl...

Ngày tải lên: 09/08/2014, 10:23

... accompanied by higher cost incre- ments. A similar phenomenon was observed using the BPI using the pain interference index. For example, an increase in the degree of pain interference by 1 point (0- ... grouped according to pain intensity (Figure 2). Direct health care costs and pain intensity due to FM were driven largely by pharmacological costs (Figure 3). However, pain interference in...

Ngày tải lên: 09/08/2014, 14:20

... in fibroblast-like synoviocytes, as seen by ELISA analysis on culture supernatant. The authors concluded that infiltrating T lymphocytes and myeloid cells are the main sources of NGF in the inflamed ... in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effect...

Ngày tải lên: 09/08/2014, 14:22

... that inhibits several enzymes in the de novo synthesis of purines and pyrimidines. Several studies have examined its efficacy in MBC beginning with a phase II study in patients with locally recurrent ... further evaluated in combination therapy. In addition to the previous study involving combination therapy with lapatinib[8], bevaci- zumab was assessed in combination with docetax...

Ngày tải lên: 10/08/2014, 22:20