Báo cáo y học: "Reshaping Cinderella’s slipper: the shared epitope hypothesis" docx

... of the influence of the glycine/valine polymorphism at position 86, thereby reducing the number of SE Commentary Reshaping Cinderella’s slipper: the shared epitope hypothesis Robert Winchester Departments ... molecules encoded by these multiple susceptibility alleles emerged from pioneering sequencing efforts and this structure was termed the shared epitope (SE) [2]. Th...

Ngày tải lên: 09/08/2014, 08:22

... and the an tibody SM3 was deter- mined by Dokurno et al. [19]. They report a significant contribution of Arg4 to b inding by analyzing the surface of the residues covered by the protein. They also ... Pro1 and the GalNAc N-acetyl methyl group with the antibody. The differences between amino acids are less pronounced than in case of the unglycosylated peptide indicating that eit...

Ngày tải lên: 21/02/2014, 15:20

... or refuting the hypothesis. Although the hypothesis also has been applied to nerve compressions other than those leading to carpal tunnel syndrome, this discussion mainly examines the original ... pulley. Excessive forearm muscle activity increases the load borne by the tendons, and therefore mechanical stress, which may lead to tenosynovitis. Although this proposal may be original,...

Ngày tải lên: 13/08/2014, 14:20

Ngày tải lên: 02/11/2012, 10:09

... experiments and participated in the design of the study and analysis of the data. FC participated in the design of the study and in the anal- ysis of data and helped to draft the manuscript. PM cloned ... is yet avail- able. The diagnosis is, therefore, based on clinical criteria. The clinical diagnosis of BD is nevertheless difficult because the signs and symptoms vary wi...

Ngày tải lên: 09/08/2014, 08:22

... daily in the jaws by masticatory forces [9]. The particular location of bisphosphonate-induced osteo- necrosis in the oral cavity may be attributable to the exposure of these bone structures to the ... bisphosphonate therapy should be individually discussed and, when necessary and possible, alternative therapy for postmenopausal osteo- porosis should be considered. The need for t...

Ngày tải lên: 09/08/2014, 08:22

... gametophyte (pollen) development is dominated by the activity of MIKC*-group genes (blue) and the development of the female gametophyte (embryo sac), embryo and seed is mainly controlled by type ... (Pteridophyte) (Lycophyte) (Bryophyte) (Charophyte) (Chlorophyte) 900 500 100 MYA 10 16 2 3 11 2 2 10 1 2 2 1 2 1 1 2 1 1 1 1 1 1 Angiosperms Seed plants Vascular plants Land plan...

Ngày tải lên: 09/08/2014, 20:22

... of physiotherapy with activity avoidance was sug- gested based on the initial clinical impression. In fact, fre- quent and regular pressure of the ganglion against the ulnar nerve during keyboard ... diagnosed by her general practitioner and physiotherapist with a right ulnar nerve neuropraxia at the level of the Guyon's canal. This was thought to be secondary to using a comput...

Ngày tải lên: 10/08/2014, 10:20

... secondary to its engagement in the her- nial sac. Although there are occasional case s diagnosed preoperatively, typically the appendix is found inciden- tally during repair without any preoperative ... erythematous groin lump [7]. The signs of appendicitis are oversha- dowed by a tight femoral hernia neck and pelvic rigidity; this anatomical feature prevents the spread of inflamma- t...

Ngày tải lên: 10/08/2014, 23:21

... four times in the fo llowing six months in both eyes. The patient was therefore commenced on oral cyclosporine 100 mg twice daily, but another two epi- sodes were n oted, and the therapy was stopped ... interpreted the ophthalmological manifestation of the disease. FP was also the major contributor in writing the manuscript. LL and IR analyzed the patient data regarding the...

Ngày tải lên: 11/08/2014, 00:22