Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs " pot
Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs." pot
... No 3 Research article Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease- modifying antirheumatic drugs Haruko Ideguchi 1 , ... with high disease activity, and in such cases it is difficult to define repair clearly. Third, there is an interval between clinical findings and corre- spondin...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" ppsx
... Vanderbilt University, Nashville, TN; Yusuf Yazici, NYU Hospital for Joint Diseases, New York, NY; Martin Bergman, Taylor Hospital, Ridley Park, PA; Christopher Swearingen, Medical University of South Carolina, ... 1994:235-246. 11. Bergstrom U, Book C, Lindroth Y, Marsal L, Saxne T, Jacobsson L: Lower disease activity and disability in Swedish patients with rheumatoid arthritis...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" potx
... Vanderbilt University, Nashville, TN; Yusuf Yazici, NYU Hospital for Joint Diseases, New York, NY; Martin Bergman, Taylor Hospital, Ridley Park, PA; Christopher Swearingen, Medical University of South Carolina, ... Ltd. ACR: American College of Rheumatology; CRP: C-reactive protein; DAS28: disease activity score using 28 joint counts; DMARD: disease- modifying antirheumatic drug; ESR:...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: "Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by peripheral blood mononuclear cells" potx
... therapeutic interventions such as anti-TNF-α and inter- leukin-1 inhibition show the importance of cytokines in RA [16]. Induction of proinflammatory cytokines via cross-linking of FcγR by ICs may be ... time points; in this way we aim to test the hypothesis that RF-associated induction of proinflammatory cytokines by joint ICs is a stable quality over space and time in individual pat...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... sCD40L R120 Introduction Increasing attention is being given to the role of IL-17, a proinflammatory cytokine produced by activated T cells, in the perpetuation of joint inflammation in rheumatoid arthritis ... factor production by rheumatoid arthritis synoviocytes and its regu- lation by Th2 cytokines. J Immunol 1998, 161:409-414. 25. Aggarwal S, Gurney A: IL-17: prototype member...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction" potx
... hyaluronidases in synovial fluids are not involved in the direct digestion of hyaluronan in joint fluids, because a neutral pH is maintained in synovial fluids, and so hyaluro- nidase-1 may function only within ... Therefore, synovial produc- tion of hyaluronan, including HMW hyaluronan, may be decreased in OA or RA. A reduced production of HMW hyaluronan may be involved in th...
Ngày tải lên: 09/08/2014, 01:24
Báo cáo y học: "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANK" pps
... RANK/ RANKL in inflammatory cells, in inflamed synovium, in artic- ular cartilage and at the invading front of bone erosions. It has been long recognized that pro-inflammatory cytokines are intimately ... staining for RANKL in synovial cells and in the infiltrating (inflammatory) cells (Fig. 4h). There was a marked increase in RANKL expression, con- sistent with the increase...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget''''s disease of bone in an Italian family" pps
... Paget's disease of bone (PDB). We originally described a methionine→valine substitution at codon 404 (M404V) of exon 8, in the ubiquitin protein-binding domain of p62/SQSTM1 gene in an Italian ... bone pain in the right pelvis increased markedly and a Figure 1 Family pedigree (F01)Family pedigree (F01). The proband, III-1, is indicated by an arrow. Members of family with ascert...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case– control study" docx
... demonstrated. Introduction Peptidylarginine deiminases (EC 3.5.3.15) are enzymes involved in the post-translational deimination of protein-bound arginine to citrulline [1]. Five different types of peptidylarginine deiminases ... HLA-DRB1 has been described [6,11,13,19], indicating the importance of antigen presenta- tion in the induction of autoimmunity. This finding clearly could be co...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection" ppt
... chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 2006, 54:692-701. 7. Listing J, Strangfeld A, Kary S, Rau R, von Hinueber U, Stoyanova- Scholz ... Symmons DPM, on behalf of the British Society for Rheumatology Biologics Register: Serious infection rates, including site-specific and bacterial intracellular infection rates,...
Ngày tải lên: 09/08/2014, 08:22