... joints, carpal joints, wrist joints and met-atarsophalangeal joints. Thirty-nine patients out of 62 had ero-sive disease. The presence of rheumatoid factor of any of the immunoglobulin isotypes ... and binding a variety of ligands. One of these ligands is high-mobility group box chromosomal protein 1,a potent proinflammatory cytokine, expression of which is increased in synovial tissue ... sRAGE? In the case of RA, there is a widediversity of RAGE ligands present in the inflamed joints, aswell as in the circulation, that could lead to the binding andconsumption of sRAGE during the...