... catalytic domain. Here, the data allowed identification of the core of the pro- tein in the N state and the evolution of the overall structure of the protein in the MG state. This degree of resolution ... furin into two fragments: the A chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T doma...
Ngày tải lên: 16/02/2014, 09:20
... and ERb was increased in both ERE1 and ERE2 in the presence of E2. Interestingly, the kinetics of E2-dependent binding of ERa and ERb to both ERE1 and ERE2 are differ- ent. The binding of ERa is ... absence of E2, and this binding was increased in the presence of E2 (Fig. 5A,B; compare 0 h and 6–8 h time points). These differences in the kinetic profiles of bind...
Ngày tải lên: 18/02/2014, 14:20
Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... cycles in such a combination do not touch each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence ... The absolute magnitude of a combined autoinfluence path is the product of all the rates divided by the product of all the concentrations of its speci...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits ppt
... presence of the a subunit of CK2 in the active cytosolic fractions (Fig. 6), and the finding that the electrophoretic mobility of the phosphorylating kinase corresponds to that of the a subunit of CK2 ... and 2 Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel A number of findings have suggested the involvement of protein...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf
... was incu- bated with insulin for 30 min in the presence of dithiothreitol, and solution turbidity was measured at 400 nm. The p26 variants tested are indicated in the figure and they appear in the ... domain. The inter- face between monomers of a dimer involves interaction between strands b2 and b6 of neighboring monomers. The p26 modifications examined in this study...
Ngày tải lên: 07/03/2014, 12:20
Báo cáo khoa học: Structural evidence for a constant c11 ring stoichiometry in the sodium F-ATP synthase doc
... c in the E. coli host cells, indicating that intrinsic fea- tures of the monomeric unit determine the number of subunits that can be packed into the ring. These data are fully compatible with the ... treatment. The observed accumulation of the incomplete c 10 complex in the recombinant c ring preparations suggests that the insertion of the last c subunit form...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: a-1 Antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum pdf
... preprohepci- din interacted with the mature form of hepcidin in BacterioMatch screening. This further supports the possibility that these proteins may play a role in the protection of prohepcidin from the ... and within 5% of each other. For the relative gene expression analysis, the 2 DDCt (Livak) method was used. The expression level of the gene of interest w...
Ngày tải lên: 16/03/2014, 01:20
Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... found in the FAD49 PX domain, as in many PX domains, suggesting that the PX domain could bind to an SH3 domain of FAD49. To test whether the PX domain could interact with an SH3 domain in FAD49, ... PX domain to phosphoinositides might be regulated by the interaction between the PX domain and the third SH3 domain, as in p47 phox , although whether the interaction of...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli pdf
... with the attachment of GMP to the phosphate group of Moco, forming the MPT guanine dinucleotide cofactor (MGD) [14,15]. In total, more than 10 genes are involved in the biosynthesis of Moco in ... caused by bind- ing to zinc binding proteins, e.g. proteins that contain zinc finger protein structures [30]. Zinc and cadmium are in the same group in the Periodic Tabl...
Ngày tải lên: 23/03/2014, 06:20
Báo cáo khoa học: On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes ppt
... Mutations in the 23S ribosomal RNA in the vicinity of the double hook binding or in the b-hairpin of protein L22 were shown to bypass the elongation arrest [72]. The swing of protein L22 hairpin tip ... space of the growing chain. Consequently, the motions of the entire chain required for progression of the nascent chain within the tunnel, should be min...
Ngày tải lên: 23/03/2014, 17:22