Báo cáo khoa học: "Male breast cancer: is the scenario changing" potx

... to support the existing vast emerging knowledge about the disease. Background Male breast cancer (MBC) comprises about 1% of all breast cancers but is found to be on the rise with the increasing ... Abstract Background: The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise. In this review we aim to present various aspects...

Ngày tải lên: 09/08/2014, 07:21

... and the complete a-helical C-terminus as held within the top of (ab) 3 . The rotary axis z was aligned along the main axis of the shaft. The ‘bearing’ included a total of 138 residues from the ... the C-terminal c portion within (ab) 3 (this work). This would make the proposed unwinding of the a-helix in c afeatureof the wild-type enzyme and an integral element of the...

Ngày tải lên: 19/02/2014, 16:20

... electron transfer during catalysis and probably to increase the stability of the expressed P450. Furthermore, there are only three cytochromes P450 encoded by the yeast gen- ome. They are either not expressed ... sides of the hydroxyl function carrying the trimethylsilyl group. This fragmentation pattern is characteristic of the derivative of 11-hy- droxyoleic acid (x-7) (M = 38...

Ngày tải lên: 07/03/2014, 03:20

... species-agonist versus partial agonist properties [16]. ThemetaboliteEisgeneratedbythecatabolismof tamoxifen, which has a lower affinity for estrogen recep- tors than tamoxifen [17-19]. However the cis isomer ... probable that the association of granulosa cell tumor and the use of tamoxifen for breast cancer is just a random observation and there is no relationship between them. A...

Ngày tải lên: 09/08/2014, 03:22

... attached the XB controller to the catheter, and inserted the radiation source into the balloon. The radiation therapy was then A CED is inserted through a small incision in the lateral breast and ... evaluate the bal- loon-to-skin distance and the degree of air and/or fluid in the breast tissue surrounding the balloon. For the pur- poses of this protocol, a minimum...

Ngày tải lên: 09/08/2014, 04:21

... mar- gins, histopatologic confirmation is the only sure differen- tial between benign and malignant disease. The differential diagnosis from cancer is the most impor- tant issue due to the very ... diagnosis. However, the two entities have substantially the same clinical and bio- logical behavior. Furthermore, differential diagnosis of a breast mass in a male routinely must...

Ngày tải lên: 09/08/2014, 07:21

... in the Norwegian breast cancer patients or risk of IBTR in the American breast cancer cases were then Schematic illustration of the ATM geneFigure 1 Schematic illustration of the ATM gene. The ... domain and PI3K domain [17] together with exonic information. (The size of the exons and the distance between them are not indicative of the sizes/distances in the gene/prot...

Ngày tải lên: 09/08/2014, 10:21

... acquisition and analysis of the data; development of the initial draft manuscript, and manuscript revisions. All authors were responsible for the interpretation of the data; review of the draft ... independent from the funders with respect to the study design; collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to sub...

Ngày tải lên: 10/08/2014, 11:20

... main hypotheses. The epidermotropic hypothesis proposes that Paget’s cells originate from ductal epithel ium, from where they migrate towards the epidermis. This hypothesis is supported by the associa- tion ... carcinoma in situ of the breast tissue or lymph node invasion. Discussion Paget’s disease is an eczematous skin change of the nip- ple that is usually associated with...

Ngày tải lên: 11/08/2014, 00:22

... dose. Interestingly, the increased PEI concentration within tumor tissues may enhance the in vivo therapeutic effect of the nanocomplex, but have no adverse effect on nor- mal tissues. Conclusions In this study, ... of both the siRNA and apta- mer that have complexed with the PEI-citrate nanocore. Further, the potential of the nanocomplex dropped to -25 ± 0.9 mV in the cell cu...

Ngày tải lên: 11/08/2014, 00:22