... neurodegenerationthrough induction of RCAN1, which in turn leads toinhibition of calcineurin and activation of GSK-3b,both resulting in tau protein hyperphosphorylation.Besides regulation of tau, both calcineurin ... subject of intense continuingstudy. So far, the only established function of theRCAN1 protein is the inhibition and regulation of calcineurin, which is protein phosphatase 2B (PP2B).Calcineurin, ... down-regulates the activity of calcineurin and activates GSK-3b. Both activation of GSK-3b and inactivation of calcineurin lead to the same results: increasedRCAN1 phosphorylation and faster proteolytic...