Báo cáo khoa học: "The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junction" ppsx

... OncologyOpen AccessCase report The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junctionWilko I ... with a locally advanced GIST of the GEJ who was first treated by imatinib mesylate followed by tumor removal with limited resection andinterposition of a segment of the jejunum (Merendino procedure) .Case ... by interposition of segment of the jejunum (Merendino procedure) . Prior to resection, downsizing of the tumor had successfully been achieved bytreatment with imatinib mesylate for six months....

Báo cáo khoa học: Catalytic residues Lys197 and Arg199 ofBacillus subtilis phosphoribosyl diphosphate synthase Alanine-scanning mutagenesis of the flexible catalytic loop ppt

... of the Vmaxvalue of the wildtype enzyme. The R201A, N203A, E206A and M208A enzymes hadVappvalues similar to the Vmaxvalue of the wildtype. The Kmvalues for ATP varied somewhat, but the values ... with the triphosphatechain of ATP either directly or indirectly through the Mg2+ion chelated to the phosphate chain of the MgATP complex or it might form hydrogen bondswith the C-2¢ or the ... [19–21]. The conformation of the ﬂagregion, of which the ﬂexible loop is a part, varies con-siderably; the loop is either completely unresolved orin a very ﬂexible state [13,14,22]. Furthermore, the...

Báo cáo khoa học: "Nutrient efficiency and resorption in Quercus pyrenaica oak coppices under different rainfall regimes of the Sierra de Gata mountains (central western Spain)" pps

... [38],increasing the NUE. Resorption is the repeated use of the same nutrient units and could therefore be a good means of estimating the efficiency of nutrient use; neverthelessresorption ... biomass production per unit of absorbed nutrient is simply the inverse of the concentra-tion of the nutrient in question in the tissues of the plant.However, in long-lived ... therefore, the nature of the underlying sub-strate does seem to have some effect on the P resorption.Furthermore, it is necessary to take the general abun-dance of...

Báo cáo khoa học: " Interactions between Scots pine, Ips acuminatus (Gyll.) and Ophiostoma brunneo-ciliatum (Math.): estimation of the critical thresholds of attack and inoculation densities and effects on hydraulic properties in the stem" pdf

... both in the phloem and the sapwood in response to bark inoculation. They maytherefore, together with the development of the fungus,have a negative impact on the water conducting ability of the ... potential. The most striking result was the significant but non-linear relationship between the amount of damage and the loss of conductivity; the latter increasing much fasterthen the former. Loss of ... al.686 The loss, that never exceeded 10%, was due to resinsoaking (20% of the loss, figure 4c) and to tissue drying(80% of the loss) in close vicinity of the wounds. The presence of the fungus...

Báo cáo khoa học: "Simultaneous adrenal and extra-adrenal myelolipoma – an uncommon incident: case report and review of the literature" pot

... prognosis. For exam-ple in case of a liposarcoma neoadjuvant treatment seemsto be the therapy of choice and not primary extensive sur-gery.In our case the intraoperative detection of the macroscop-ically ... and the importance of the surgeons' intraoperative judgement of the tumour, concerning an unknown primary tumourlocated in the adrenal gland and the retroperitoneum.Competing interests The ... benign lipoma-tous tumour. Following the above mentioned secondoption first an adrenalectomy was performed. The rapidsection of the adrenal lesion revealed the result of a mye-lolipoma. Having...

Tài liệu Báo cáo khoa học: "An Information-Theory-Based Feature Type Analysis for the Modelling of Statistical Parsing" docx

... types is, the headword of the currentnode (type1), the headword of the parent node(type2), the headword of the grandpa node(type3), the first word in the objective wordsequence(type4), the first ... brother of the current node 0.5832 2.1511 1.2186Y= the second right brother of the current node 0.1066 0.5044 0.2525Y= the second left brother of the current node 0.0949 0.6171 0.2697Y= the ... first right brother of the parent 0.1068 0.3717 0.2133Y= the first left brother of the parent 0.2505 1.5603 0.61455.2 The analysis to the influence of the structural relation and the structuraldistance...

Báo cáo khoa học: Estrogen-related receptor a and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria potx

... regulation of the three thyroid cell linesWe investigated the effects of XCT790, a speciﬁcinverse agonist of ERRa. As controls of the inhibitoryeffect of XCT790 on ERRa, we used the expression of ERRa-validated ... study, we looked for the effect of the ERR a–PRC complex 48 h after overexpression of PRC and ERRa. We suspect that a further period of treatment may be required to reveal the effect of the complex ... suggesting that the ERRa–PRC complex is involved in the control of the earlyphase of the cell cycle. This is in accordance with the role played by PRC and ERRa in the transition from the G1 to the S...

Báo cáo khoa học: Peptides from puriﬁed soybean b-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain pot

... the DOCK function of moe. The initial 3D structures of the ligands were con-structed using the BUILDER function in the moe program. The initial positions of these compounds were set within the ... further understand the structure–potency relation-ship of the FAS inhibitory peptides, we examined the relationships between the physicochemical andbiochemical features of these peptides and their ... betweeninhibitors and the thioestherase (TE) domain.Calculated using the MOE program following the method of Clark & Labute [44], residuesin the TE domain that contribute to the bind-ing of EITPEKNPQLR...

Báo cáo khoa học: "An Intelligent Procedure Assistant Built Using REGULUS 2 and ALTERF" pptx

... and p is the probability p(a | f) estimated by the trainingprocess.3. Order the set of triples by the value of p, with the largest probabilities ﬁrst. Call the orderedset T .4. Remove the highest-ranked ... 2)where Nfis the number of occurrences in the train-ing data of utterances with feature f, and Nafis the number of occurrences of utterances with both fea-ture f and semantic atom a. The decoding ... built on top of the general grammar istransformed into a specialised Nuance grammar in the following processing stages:1. The training corpus is converted into a “tree-bank” of parsed representations....

Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx

... suggested that the size of the resulting ring and the preorganization of the substratedetermine whether a ligation or a cyclization step iscarried out [39]. Unfortunately, the prefold of the lin-ear ... enable the speciﬁcangle, following the Bu¨rgi–Dunitz trajectory, required for the nucleophilic attack onto the acyl-O-TE oxo-ester intermediate [36]. Furthermore, the correct posi-tioning of the ... 2009 The Authors Journal compilation ª 2009 FEBS of the cyclic product [9]. Furthermore, the rigidiﬁca-tion of the molecule reduces structural ﬂexibility, leadsto the conformation required for...

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