Báo cáo y học: "Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production" pot

... http://arthritis-research.com/content/8/3/R62 Page 1 of 14 (page number not for citation purposes) Vol 8 No 3 Research article Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement ... saline; PE = phycoerythrin; PerCP = peridinin chlorophyll protein; SD = standard deviation; SLE = systemic lupus...

Ngày tải lên: 09/08/2014, 07:20

... retention of granulo- cytes within lesions. Synovial fibroblasts are indeed potent producers of cytokines, adhesion molecules, and chemokines that attract and retain large numbers of leukocytes in the inflamed ... tissues We investigated JAM-C expression in human OA and RA syn- ovial samples by IHC using polyclonal antibodies against human JAM-C. Interestingly, expression of...

Ngày tải lên: 09/08/2014, 10:20

... [Sar 9 ,Met(O 2 ) 11 ]SPforthe NK 1 receptor. Characterization of hHK-1- and endokinins-induced responses in guinea pig airways Contractile effects of hHK-1 and endokinins in isolated guinea pig airways Human hemokinin-1 induced concentration-dependent contractions ... decapeptide of EKA and EKB [6,38]), EKC and EKD in human and guinea-pig isolated airways. Finally, effe...

Ngày tải lên: 12/08/2014, 11:22

... five-amino-acid insertion in the PX domain (Fig. 1). To determine the effect of the insertion, we examined the phosphoinositide-binding activity of the PX domain of Noxo1c by an overlay assay, in ... homology (PX) domain in the N-terminus. PX domains occur in a variety of proteins involved in cell signaling, mem- brane trafficking, and polarity establishment, and func- tio...

Ngày tải lên: 19/02/2014, 06:20

... classes. Role of Tyr183 in catalysis In previous crystallographic studies it was shown that the hydroxyl side chain of Tyr183 is within hydrogen bonding distance of the N-acetyl carbonyl oxygen of the ... protein as judged by SDS/ PAGE. The activity of the pure recombinant protein was 80% of that of t he wild-type protein in both the lysozyme and chitinase assays. Attemp...

Ngày tải lên: 22/02/2014, 04:20

... an enzyme with marked functional similarities to bovine carboxylase, including vitamin K epoxidase activity, but with several differences that yield additional insight into the enzymology of this ... resides in the endoplasmic reticulum [12– 14]. The propeptide-binding site, the active site, and the vitamin K-binding site of the c-carboxylase have not been defined with certainty...

Ngày tải lên: 17/03/2014, 10:20

... the site of injection Injection of microorganisms resulted in a dramatic decrease in numbers of both circulating and tissue in ltrating haemocytes within 3 h of injection. To study haemocyte behaviour ... immunoreactivity observed at the site of microbial injection precluded both clarification of the mechanisms of penaeidin release from haemocytes, and determination of...

Ngày tải lên: 18/03/2014, 01:20

... plays a central role in innate and acquired immune response. Elucidating the mechanisms by which miR-155 expression is controlled and finding its targets will bring more understanding of ... Cytokines; Drug discovery; Hematopoietic lineage; Innate immune response; TNF-α. Introduction Since their discovery, micro RNAs (miRNAs) have been implicated in a wide array of cellular...

Ngày tải lên: 08/08/2014, 17:20

... suppression of joint inflammation. CCL18 has already been recognized in tissues and joints of patients with RA. In particular, high levels of CCL18 were measured in SF, and immunostaining of tissue ... However, Iking-Konert and colleagues [36] suggested Figure 4 Induction of CCL18 mRNA and protein in synovial fluid and blood polymorphonuclear neutrophilsInducti...

Ngày tải lên: 09/08/2014, 10:21

... disc cells in terms of disease pathology has yet to be fully examined. A role for the proinflammatory cytokines TNFα and IL-1β in innervation of the IVD [22] and in degeneration of the IVD has been ... article Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc Devina Purmessur, Anthony J Freemont and Judith A Hoyl...

Ngày tải lên: 09/08/2014, 11:20