Báo cáo y học: "NGR1 single nucleotide polymorphisms in rheumatoid arthritis" pdf

... primer). Results and discussion In marked contrast to previous findings, no polymorphic alleles (neither thymine at position 40 nor cytosine at position 1,400) were detected in any of the individuals tested. ... sur- prising because both positions were highly polymorphic in the original publications. In those publications, heterozygosity at position 40 (V14M) was detected in four in...

Ngày tải lên: 09/08/2014, 07:20

... effect, infusion, and injection site reactions, which may result in expectation bias as well as unblinding. Most importantly, placebo has been necessary to prove inefficacy of many ‘promising’ agents [41], ... Sandberg G, Crayton H: Demyelination occurring during anti TNF therapy for inflammatory arthritides. Arthritis Rheum 2001, 44:2862- 2869. 65. Robinson WH, Genovese MC, Moreland LW: De...

Ngày tải lên: 09/08/2014, 01:22

... of inflammatory cells, including monocytes and lymphocytes [1]. It has been proposed that the first cells to infiltrate syn- ovial tissue are T lymphocytes, suggesting that they have an important role in ... newly emerging anti-inflammatory properties, may have important implications for treatment in chronic inflam- matory diseases. Competing interests The authors declare that they have n...

Ngày tải lên: 09/08/2014, 01:24

... proliferating mass of synoviocytes locally invades the cartilage and bone, destroy- ing the joint. MMPs, mainly produced in FLS, play a central role in arthritic joint destruction. Beyond the ... bromide staining. Gelatin zymography Gelatin zymography was performed for detection of MMP activity in conditioned medium. FLS and THP-1 cells were cul- tured overnight using ordinary serum-con...

Ngày tải lên: 09/08/2014, 07:20

... disease activ- ity assessment in RA. In this study, we showed that the assessment of joint activity in the feet, beyond assessment of joint activity by the 28-joint count, does not convey significant added ... classification into remission. Thus, by indices that employ the 28-JC, there is only a very small number of patients in remission who have joints involved that are not contained...

Ngày tải lên: 09/08/2014, 10:20

... H, Hyldstrup L; the TIRA group: Bone loss in unclassified polyarthritis and early rheumatoid arthritis is better detected by digital X-ray radiogrammetry than dual energy X-ray absorptiometry: ... well the erosive status of patients. In this study the reduction in DXR- BMD after 1 year was rather specific (100%) and highly sen- sitive (63%) in identifying those patients with an acce...

Ngày tải lên: 09/08/2014, 10:22

... and MRI in a study of nine RA wrist joints by Perry and colleagues [12] may partly be explained by more advanced joint destruc- tions in their cohort. In comparison with our previous study on RA ... MRI volumes. *P < 0.01. a Intramodality agreement, reading A minus reading B; intermodality agreement, CT erosion volume minus MRI erosion volume. b Intramodality agreement, positive va...

Ngày tải lên: 09/08/2014, 10:23

... Core protein fragments Keratan sulfate fragments Noncollagen and Cartilage oligomeric matrix protein COMP nonaggrecan proteins Bone Type I collagen Pyridinoline, deoxypyridinolin PYD, DPD Type I ... function, including proteins involved in the Wnt signaling pathways [85], may therefore constitute further interesting markers for the future. Importantly, however, achieving low disease activit...

Ngày tải lên: 09/08/2014, 10:23

... [21]. Sirtuins, as well as other nicotinamide adenosine dinucleotide-dependent enzymes, are inhibited by nicotinamide. A growing list of sirtuin inhibitors, including sirtinol, is being identified ... activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling, may increase the DNA binding and activity of transcription factors, and may increase .....

Ngày tải lên: 09/08/2014, 11:20

... studies investigating the potential role played by reduced reactive oxygen species production in human RA have yet been reported. In order to examine the role played by the NOX complex in RA, we investigated ... using this stringent method. The EIRA study included mainly individuals born in Sweden. Taking those born outside Sweden into consideration also, 97% were of Caucasian origin....

Ngày tải lên: 09/08/2014, 10:21