Báo cáo y học: "Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans" pptx

... Iozzo RV: The biology of the small leucine-rich proteoglycans. J Biol Chem 1999, 274:18843-18846. 4. Ameye L, Young MF: Mice deficient in small leucine-rich pro- teoglycans: novel in vivo models ... Roughley P, Pelletier J-P, Martel-Pelletier J: Degradation of small leucine- rich repeat proteoglycans by MMP-13: identification of a new biglycan cleavage site. Arthritis Re...

Ngày tải lên: 09/08/2014, 07:20

... of a phycobiliprotein lyase: both the attachment of phy- cocyanobilin and the isomerization to phycoviolobilin are cata- lyzed by the proteins PecE and PecF encoded by the phycoerythrocyanin operon. ... a lyase-isomeraseforthephotoactive3 1 -Cys-a84-phycoviolobilin chromophore of phycoerythrocyanin. Biochemistry 40, 12444– 12456. Ó FEBS 2002 Analyses of a-phycoerythrocyanin peptid...

Ngày tải lên: 17/03/2014, 10:20

... of monocyte/macrophages [34]. As macrophages initiate the inflammatory process and are the source of many cytokines responsible for cartilage and bone loss, this may be a primary mechanism by ... collected by intracardiac puncture while tissues were isolated as outlined below. Evaluation of development of arthritis Disease activity of the CIA was assessed every other day betwe...

Ngày tải lên: 09/08/2014, 07:20

... shared by all CD44 isoforms, can markedly reduce the inflammatory activity of arthritis induced by collagen or proteoglycans in mice. Anti-CD44 mAb also interferes with the migration of RA synovial-like ... Nuki G: CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocyte...

Ngày tải lên: 09/08/2014, 01:21

... production by these cells by neutralizing the endogenously produced IL-18, indicating the importance of endogenous IL-18 in IFN-γ production by RA synovium. Discussion Several lines of evidence ... single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthritis Rheum 1998, 41:1669-1676. 13....

Ngày tải lên: 09/08/2014, 01:23

... effectiveness of some of the compounds in animal models because of species selectivity, which could delay development. In addition, development may be hampered by low oral bioavailability of some of the ... inflammatory arthritis, daily injection of the antagonist MCP-1(9–76) prevented the onset of arthritis whereas controls treated with native MCP-1 had enhanced arthritis...

Ngày tải lên: 09/08/2014, 01:23

... are not only of lower affinity and avidity but are also less protective against infection than those produced by young mice. Thus, the poor quality of the primary humoral response of aged animals ... production by T lymphocytes from young and aged mice. J Immunol 1996, 156:3621-3630. 60. Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P: Control of homeostasis of CD8 + memory...

Ngày tải lên: 09/08/2014, 01:23

... acetylation of a lysine residue (532) in HIF-1α [71,72]. The hydroxylation events are mediated by a family of three prolyl hydroxylases (PHD-1, PHD-2, and PHD-3) and one asparagine hydroxylase ... Kim JR, Hwang BY, Lee HY, Song EK, Yoo WH: NF- κκ B-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: poten- tial role in rheumatoid arthritis. J...

Ngày tải lên: 09/08/2014, 01:24

... simply rep- resents the coincidental occurrence of psoriasis and inflammatory arthritides such as rheumatoid arthritis (RA) or ankylosing spondylitis [2]. A review of the investigation of PsA ... has reported a prevalence of psoriasis of 1.7%, and of psoriasis associated with IA of 0.3% [3]. Community surveys have reported incidences of psoriasis in 4.5–5.3% of patients pr...

Ngày tải lên: 09/08/2014, 03:24

... the absence of damage, one can then ask the following types of question: How much of chronic pain is caused by mechanisms that are initiated by acute pain processes in the periphery, for example ... fundamentally different mechanism of action from that of traditional NSAIDs or opioid-type drugs. This discrepancy is illustrated by the promise suggested for neurokinin-1 antagoni...

Ngày tải lên: 09/08/2014, 06:22