Báo cáo y học: "Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans" pptx

... Iozzo RV: The biology of the small leucine-rich proteoglycans.J Biol Chem 1999, 274:18843-18846.4. Ameye L, Young MF: Mice deficient in small leucine-rich pro-teoglycans: novel in vivo models ... Roughley P,Pelletier J-P, Martel-Pelletier J: Degradation of small leucine-rich repeat proteoglycans by MMP-13: identification of a newbiglycan cleavage site. Arthritis Res Ther 2006, 8:R26.2. Young ... use of neoepitopeantibodies directed toward cryptic amino or carboxyl termini exposed following proteolytic action, as have beensuccessfully applied for the detection of aggrecan and type IIcollagen...

Báo cáo Y học: Puriﬁcation, crystallization, NMR spectroscopy and biochemical analyses of a-phycoerythrocyanin peptides pptx

... of a phycobiliprotein lyase: both the attachment of phy-cocyanobilin and the isomerization to phycoviolobilin are cata-lyzed by the proteins PecE and PecF encoded by thephycoerythrocyanin operon. ... alyase-isomeraseforthephotoactive31-Cys-a84-phycoviolobilinchromophore of phycoerythrocyanin. Biochemistry 40, 12444–12456.Ó FEBS 2002 Analyses of a-phycoerythrocyanin peptides (Eur. J. Biochem. 269) 5055Optical spectroscopyThe ... Mu¨nchen,GermanyThe a-phycoerythrocyanin subunits of the diﬀerent phy-coerythrocyanin complexes of the phycobilisomes fromthe cyanobacterium Mastigocladus laminosus perform aremarkable photochemistry....

Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps

... of monocyte/macrophages [34]. As macrophages initiatethe inflammatory process and are the source of manycytokines responsible for cartilage and bone loss, this may bea primary mechanism by ... collected by intracardiac puncture while tissueswere isolated as outlined below.Evaluation of development of arthritis Disease activity of the CIA was assessed every other daybetween days 21 and ... collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a genetherapy. Arthritis Rheum 1999, 42:2532-2542.25. Hashiramoto A, Sano H, Maekawa T, Kawahito Y, ...

Báo cáo y học: "CD44 in rheumatoid arthritis" pot

... shared by all CD44 isoforms, can markedly reduce theinflammatory activity of arthritis induced by collagen or proteoglycans in mice. Anti-CD44 mAb alsointerferes with the migration of RA synovial-like ... Nuki G: CD44 expression by leucocytes inrheumatoid arthritis and modulation by specific antibody:implications for lymphocyte adhesion to endothelial cells andsynoviocytes in vitro. Scand J ... macrophagesand lymphocytes) initiated by physical injury, infection oran immune response, is normally a self-limiting episode.The inflammatory response is fostered by the upregulation of adhesion...

Báo cáo y học: "Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis" doc

... production by thesecells by neutralizing the endogenously produced IL-18,indicating the importance of endogenous IL-18 in IFN-γproduction by RA synovium.DiscussionSeveral lines of evidence ... single-cell analysis of cytokine production by CD4+ T cells in synovial tissue andperipheral blood from patients with rheumatoid arthritis. Arthritis Rheum 1998, 41:1669-1676.13. Morita Y, Yamamura ... production by spontaneous PBMC culturecould not be detected at day 3 or 5 (Fig. 1d). Accordingly,concentrations of 1 ng/ml of IL-12, 5 ng/ml of IL-18, and2 µg/ml of IL-18BP for 7 days of culture...

Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx

... effectiveness of some of thecompounds in animal models because of speciesselectivity, which could delay development. In addition,development may be hampered by low oral bioavailability of some of the ... inflammatory arthritis, daily injection of theantagonist MCP-1(9–76) prevented the onset of arthritis whereas controls treated with native MCP-1 hadenhanced arthritis symptoms [22]. Of importance ... rheumatoid synovium, and most of theCCR1-positive cells are macrophages, which play a keyrole in synovial inflammation. The rationale for the clinicalstudy was supported by interesting properties of...

Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity" pptx

... are notonly of lower affinity and avidity but are also less protectiveagainst infection than those produced by young mice.Thus, the poor quality of the primary humoral response of aged animals ... production by T lymphocytes from young and aged mice. J Immunol 1996,156:3621-3630.60. Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P: Control of homeostasis of CD8+memory T cells by opposingcytokines. ... variations of antibody avidity. Immunology 1978, 35:601-611.75. Nicoletti C, Yang X, Cerny J: Repertoire diversity of antibodyresponse to bacterial antigens in aged mice. III. Phosphoryl-choline...

Báo cáo y học: "Oxidation in rheumatoid arthritis" docx

... acetylation of a lysine residue (532)in HIF-1α [71,72]. The hydroxylation events are mediated by a family of three prolyl hydroxylases (PHD-1, PHD-2,and PHD-3) and one asparagine hydroxylase ... Kim JR, Hwang BY, Lee HY, Song EK,Yoo WH: NF-κκB-dependent lymphocyte hyperadhesivenessto synovial fibroblasts by hypoxia and reoxygenation: poten-tial role in rheumatoid arthritis. J Leukoc ... as RA synovium, and indicate thatthe regulation of specific genes by hypoxia occurs in thecontext of multiple other regulatory pathways, particularlythe NF-κB pathway.Hypoxia, or hypoxia...

Báo cáo y học: " Genetic epidemiology Psoriatic arthritis" ppsx

... simply rep-resents the coincidental occurrence of psoriasis andinflammatory arthritides such as rheumatoid arthritis (RA)or ankylosing spondylitis [2]. A review of the investigation of PsA ... hasreported a prevalence of psoriasis of 1.7%, and of psoriasisassociated with IA of 0.3% [3]. Community surveys havereported incidences of psoriasis in 4.5–5.3% of patientspresenting with ... primarily a disease of enthesitiswith secondary synovial inflammation, and that arthritis per se, in the presence of psoriasis, does not representPsA [7].ReviewGenetic epidemiologyPsoriatic arthritis Anne...

Báo cáo y học: "What can chronic arthritis pain teach about developing new analgesic drugs" ppt

... the absence of damage, one can then ask the following types of question: How much of chronic pain is caused by mechanisms that are initiated by acute pain processes inthe periphery, for example ... fundamentallydifferent mechanism of action from that of traditionalNSAIDs or opioid-type drugs. This discrepancy isillustrated by the promise suggested for neurokinin-1antagonists by animal-based ... between acute (days to weeks) and chronic(months) pain may also be problematic because keypathophysiologic processes may diverge early in thedevelopment of pain chronicity. Chronic pain studiesbased...

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