Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps

... and in vivo studies showed that methotrexate is ineffective in the presence of antagonists of adenosine or adenosine deaminase (the enzyme responsible for the deamination of adenosine to inos- ine) ... the anti-inflammatory effects of methotrexate and adenosine are mediated by different receptors in different inflammatory loci, an observation that may explain w...

Ngày tải lên: 09/08/2014, 07:20

... treatment of airway inflammatory diseases, since M-4 does not show any antimicrobial activity [17]. NO is primarily derived from a cationic amino acid, L-arginine, and oxygen by a family of NOS. ... subjects. Assay for inducible NO synthases (iNOS) The iNOS levels in cytosol were assayed by commer- cially available human iNOS ELISA kits (R & D Systems, Inc., Minneapolis , MN...

Ngày tải lên: 11/08/2014, 03:20

... treatment of airway inflammatory diseases, since M-4 does not show any antimicrobial activity [17]. NO is primarily derived from a cationic amino acid, L-arginine, and oxygen by a family of NOS. ... subjects. Assay for inducible NO synthases (iNOS) The iNOS levels in cytosol were assayed by commer- cially available human iNOS ELISA kits (R & D Systems, Inc., Minneapolis , MN...

Ngày tải lên: 11/08/2014, 06:22

... Shore, V.G., Fielding, P.E. & Egelrud, T. (1973) Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of tri- glycerides by lipoproteins lipase from ... The morphology of the fibrils appeared indistinguishable to that of fibrils formed in the absence of clusterin [6]. Distinctive features of clusterin alone were not visible a...

Ngày tải lên: 24/03/2014, 04:21

... 6. Results Inflammation of the skin by curdlan intradermal injection Skin inflammatory response induced by intradermaly injected curdlan (0.5 mg/50 µl), was investigated first by using two parameters, ... application of essential oils on the accumulation of neutrophils in inflammatory sites in skin of mice. Methods: Inflammation with accumulation of inflammatory cells...

Ngày tải lên: 11/08/2014, 08:21

... phosphorylation of conserved tyrosine and threonine residues within the catalytic domain. This phosphorylation is mediated by dual specificity protein kinases, members of the MAPK kinase (MKK) family. ... systems. REGULATION OF SAPK SIGNAL PATHWAYS BY PROTEIN PHOSPHATASES IN YEAST CELLS A molecular g enetic analysis of ye ast cells indicated that two distinct protein phosphat...

Ngày tải lên: 17/03/2014, 23:20

... a serine peptidase characterized by oligopeptidase activity. It is grouped in family S9A in clan SC [1]. Enzymes belonging to clan SC are distinct from trypsin-type and subtilisin-type serine ... in phenotype. Fig. 1. Western-blot analysis of PEP expression in established antisense cell lines. The PEP activity remaining in each antisense cell line cor- responds to the signal i...

Ngày tải lên: 31/03/2014, 08:20

... chemotaxis and proinflammatory cytokine synthesis [36]. Interestingly, it also causes hyperesthesia, including by local injection into rodent paws, and mice lacking the PROK receptor PKR1 have dimin- ished ... dimin- ished pain responses [37]. It is therefore intriguing to specu- late that PROK-2 contributes to the symptoms of MSU crystal inflammation by enhancing both inflammati...

Ngày tải lên: 09/08/2014, 10:23

... carriers is the current paradigm for bone induction in the clinical setting [9]. The potential of inhibiting the inhibitors is therefore of great interest, because a single inhibitor - such as noggin ... of the role played by chordin in osteogenesis. The authors demonstrated successful knockdown of chordin expression by small-interfering RNA transfection of human MSCs cu...

Ngày tải lên: 09/08/2014, 10:23

... with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infected patients using antiretroviral ... in HIV-1-infected individuals receiving combination antiretroviral therapy. HIV Med 2009, 10:627-33. 11. Libby P, Ridker PM: Inflammation and atherosclerosis: role of C-re...

Ngày tải lên: 10/08/2014, 05:21