Báo cáo y học: "Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus" pot
Báo cáo y học: "Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus" pot
... production of cytokines, and increased T cell stimulatory capacity before and after the onset of the disease [14]. In our study we analyzed DCs in the original NZM2410 and NZB-W/F1 mice before and after ... No 2 Research article Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk – A Meta-Analysis"
... author’s name, year of publica- tion, country of origin, ethnicity, type of asthma, number of cases and controls, and the minor allele fre- quency in controls. Meta-Analysis. The risk of asthma ... Immunol. 1993; 150: 3442-8. 24. Schall TJ, Bacon K, Toy KJ, et al. Selective attraction of monocytes and t lymphocytes of the memory phenotype by cytokine rantes....
Ngày tải lên: 26/10/2012, 09:39
Báo cáo y học: " Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection" pot
... cell therapy [9]. Recently we demonstrated derivation of phe- notypically and functionally normal macrophages from hES-CD34+ cells and established that they could support HIV-1 infection. These ... progenitor cells and spread via the bloodstream and lymphatics [12,13]. They are found in almost every organ as sentinels of the immune system. In innate immunity, DCs function...
Ngày tải lên: 10/08/2014, 05:20
Báo cáo y học: " Abnormal macrophage response to microbial stimulus in a 43-year-old man with a severe form of atherosclerosis: a case report" pptx
... assessment of the efficacy of drug therapy. Introduction Atherosclerosis is the leading cause of death in the majority of industrialized countries. The absence of “tra- ditional” risk factors and the ... neces- sarily prove the existence of atherogenic effects, particularly in view of the widespread distribution of the microorganisms involved. Several authors...
Ngày tải lên: 11/08/2014, 12:20
Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... to that of APRIL homotrimers. The reduced potency of the heterotrimer ligands in the pri- mary human B cell-proliferation assay compared with the homotrimeric BLyS may be explained by the predo- minant ... the Hisx6-zz12.6 form of BLyS, and an ti-BLyS pAb followed by donkey anti-rabbit IgG-HRP for the trypsini zed form of BLyS. The molecular mass of the heterotri...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: " Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment" pot
... production of reactive oxygen species and inflammatory mediators by alveolar macrophages (AM) [4-7] and epithelial [7-10] and other lung cells [11]. When AM and airway epithelial cells are directly exposed ... dishes and cultured in BEGM. Light microscopy showed that 95% of the isolated cells had features of bronchial epithe- lial cells, that is they formed a monolaye...
Ngày tải lên: 12/08/2014, 18:22
Báo cáo Y học: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 potx
... whether hspry4 can be phosphorylated and palmitoylated similar to spry1 and spry2, and if TESK1 can interact with other spry proteins (directly). Finally, in view of the strength and specificity ... although further proof of a functional interaction is required. The relatively low levels of expression of the two proteins and the limited sensitivity/specificity of cur...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf
... occurrence of MMP peptide-specific T cells during AA The PLN responses were analyzed in lymphocyte prolifera- tion assays at day 0 (naïve animals), day 10 (before clinical onset of disease), day 14 (onset ... such therapies. Acknowledgements The authors thank MC Grosfeld for the peptide–MHC binding assays. The research by Dr MHM Wauben was made possible by a fellowship of...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
... histological analysis of synovial fibrosis and PG content of the cartilage. Histology Knee joints of mice were dissected and fixed in phosphate- buffered formalin for 7 days. Thereafter, they were decalcified in ... one of the synovial lining cells and thereby fully block the TGF-β-induced fibrosis. We have previously demonstrated that blocking TGF-β with Ad-Smad7 in OA...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt
... design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript. AJF participated in the design of the study and interpretation of data. JAH conceived the ... to cytokines and growth factors [15]. Our data indicate that the senescent phenotype is linked to the increased production of degradation enzymes which ma...
Ngày tải lên: 09/08/2014, 10:20