Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx

... has been demonstrated that patients with SLE have a lower level of 25 hydroxyvitamin D3 than do healthy controls [3]. In addition, high-dose 1,25-dihydroxyvitamin D3 and its analog may be useful ... pancreas, bone, skin, gonads, and activated T and B lymphocytes, have the nuclear receptor for 1,25-dihydroxyvitamin D3 (VDR). Thus, it is not surprising that 1,25-dihydroxyvitamin D3...

Ngày tải lên: 09/08/2014, 07:20

... relia- bility of radiographs' readings. HR conceived of the study and participated in its design. PLA conceived of the study and par- ticipated in its design and coordination. All authors read and approved ... unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Abstract We examined whether polymorphisms of the vitamin D receptor...

Ngày tải lên: 09/08/2014, 07:20

... asso- ciated rapid response steroid binding receptor (MARRS) [8]. Certain polymorphisms of the VDR gene may modify vitamin D function and metabolism and have been exam- ined in studies evaluating the ... sclerosis (MS) and osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age...

Ngày tải lên: 11/08/2014, 07:21

... their role in the maintenance of disease. In addition, inhibition of γ/δ activation, and there- fore of proinflammatory cytokine production, may provide an interesting therapeutic strategy for novel ... and IL-12 receptors. Twenty-five patients and 45 healthy individuals were studied. Vγ9/Vδ2 T cells were analyzed by fluorescence activated cell sorting, utilizing specific monoclonal ant...

Ngày tải lên: 09/08/2014, 01:23

... experimental condi- tions, we did not stain CD38 with HLA-DR simulta- neously. At baseline the median proportion of activated CD8+ T lymphocytes (CD38+) exceeded 80% and gra- dually declined over 12 ... ART. Background CD8+ T cells play an important role in protection against intracellular pathogens. Eliminating CD8+ T lymphocytes from monkeys during chronic SIV infection resulted in a...

Ngày tải lên: 10/08/2014, 05:22

... were included only and divided into two groups according to t he tech- nique used during myocardial revas cularization. Ninety eight patients underwent OPCAB, while thirty nine patients had ONCAB/BH ... early morbidity and mortality. J Card Surg 2006, 21:22-27. 2. Youn YN, Chang BC, Hong YS, Kwak YL, Yoo KL: Early and mid-term impacts of cardiopulmonary bypass on coronary artery bypass gr...

Ngày tải lên: 10/08/2014, 09:22

... to defined CTDs. In our previous study, we found the shift toward Th1 with increased IFN-γ production in patients with UCTD combined with the degree of immunoregulatory disturbances characterized ... develop into any well-defined CTDs [16-18]. Evolution into a specific established CTD was found in 21.7% of patients with UCTD during the follow-up period. UCTD most frequently...

Ngày tải lên: 09/08/2014, 13:22

... established autoimmune CTD is of great interest [1]. Patients who progressed into CTDs had lower vitamin D levels than those who remained in the UCTD stage and UCTD most frequently progressed into ... study by Zold and colleagues reporting that, during the average 2.3 year follow-up period, 21.7% of patients with UCTD and a deficiency of vitamin D metabolites (hormone D) further...

Ngày tải lên: 09/08/2014, 13:22

... phagocytosis and adherence AC = adenylyl cyclase; ADA = adenosine deaminase; AR = adenosine receptor; B max = maximum number of binding sites; CGS 21680 = (2-p-[2-car- bowyethyl]pheylethylamino)-5'N-ethylcarboxamidoadenosine; ... a decrease in A 2B AR mediated adenylyl cyclase activity was observed in patients with SSc. Our findings demonstrate the occurrence of selective alt...

Ngày tải lên: 09/08/2014, 06:22

... the time indicated by the arrow in (a). (a) Density plots of the rate of CD62L shedding in each cell population, as indicated by decreased binding of anti- CD62L FITC . (b) Corresponding levels ... stained with a combination of CD4 APC , CD4 CYCHROME , CD4 PE , CD8 APC , CD8 CYCHROME , CD8 PE , CD8 FITC and CD62L FITC antibodies (Becton Dickinson, Oxford, UK) as indicated, washed and...

Ngày tải lên: 09/08/2014, 06:22